Objective: Lichenoid drug reactions (LDR) are
a rarely known type of drug reaction that resembles lichen planus. The exact
etiology of LDR is not known but it is thought to be caused by the triggering
of all kinds of chemical substances. In this study; we aimed to investigate
the clinical and demographic characteristics of the patients who were
diagnosed with LDR.
Material and Method: The files of 56 LDR patients who
were followed in our outpatient clinic among 2011 - 2016 have been reviewed
retrospectively. The demographic characteristics, the drugs considered to
cause reaction, the presence of multiple drug usage, the duration between
drug intake and appearance of the initial skin eruption, clinical findings,
lesion locations, laboratory findings and associated diseases have been
recorded.
Results: Out of the 56 LDR patients, who
were clinically and histopathologically diagnosed and followed, 36 were
female and 20 were male. The average age was 52.8 (19-86 years of age). The
duration of the symptoms was between 1-3 months in 58.9% of the patients,
between 3-12 months in % 17.8, between 1 to 30 days in % 14.2 (n=8) and more
than 1 year in 8.9% of the patients.48.2% (n = 27) of the lesions were on the
extremities, 37.5 % were generalized, 7.1% were invers type. The most
frequently accused drug groups were nonsteroidal anti-inflammatory drugs
(NSAID) and antihypertensive.
Conclusions: It has been found that the use of
NSAID, and cardiovascular drugs on their own and / or in combination with
other medications often led to lichenoid drug reactions.
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