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Is there any relationship between H. pylori gastritis and mucosal esophagitis?

Yıl 2019, , 14 - 18, 31.03.2019
https://doi.org/10.33204/mucosa.539459

Öz

Background Gastroesophageal reflux disease (GERD) and H.Pylori gastritis are common seen in childhood. In the literature, it was found that the incidence of H. pylori infection in patients with GERD was between 30-90%. Coexistence of two diseases is one of the topic and controversial issue in these days. In our study; we aimed to assess the prevalence of GERD in pediatric patients with and without H. pylori gastritis, and investigate whether H. pylori infection is a risk factor for GERD.

Methods The patients undergoing endoscopic examination in Karadeniz Technical University, Faculty of Medicine, Pediatric Gastroenterology, Hepatology and Nutrition clinic between January 2009 - January 2019 included in the study. The data of patients were recorded from the hospital files retrospectively. The patients were divided in two groups according to whether H. pylori infection positive and negative. GERD frequency, indication of endoscopy and demographic characteristics were compared.

Results Among the 4337 patients (55.5% female, mean age ± SD; 9.5 ± 4.4 years, range; 6 months-19 years), 348 patients (8%) had GERD, and 779 patients (18%) had H. pylori gastritis. There was no significant difference in gender between patients with H. pylori positive and negative (p>0.05). We determined that the age of patients with H. pylori gastritis was older (p=0.000). The prevalence of GERD in the H. pylori negative patients was 8.4% compared to 6.2% in the H. pylori positive patients [OR, 0.71 95% CI (0.52-0.98), p = 0.030].

Conclusions Our study showed that H. pylori infection had a protector role for GERD. We could not evaluate the patients reflux symptoms after H. pylori eradication therapy. Therefore, further prospective studies are needed.

Kaynakça

  • 1. Rosen R, Vandenplas Y, Singendonk M. et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendation of the North American Society for Pediatric Gastroenterology, Hepatology,and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. JPGN 2018;66:516-54.
  • 2. Nordenstedt H, Nilsson M, Johnsen R, Lagergren J, Hveem K. Helicobacter pylori infection and gastroesophageal reflux in a population-based study (The HUNT Study). Helicobacter 2007;12:16-22.
  • 3. Tanaka I, Tatsumi Y, Kodama T, et al. Effect of Helicobacter pylori eradication on gastroesophageal function. J Gastroenterol Hepatol 2004;19:251-7.
  • 4. Nwokolo CU, Freshwater DA, O’Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut 2003;52:637-40.
  • 5. Dominguez-Mu-oz JE, Malfertheiner P. Effect of Helicobacter pylori infection on gastrointestinal motility, pancreatic secretion and hormone release in asymptomatic humans. Scand J Gastroenterol 2001;36:1141-7.
  • 6. Wu JC, Sung JJ, Ng EK, et al. Prevalence and distribution of Helicobacter pylori in gastro-oesophageal reflux disease: a study from the East. Am J Gastroenterol 1999;94:1790-4.
  • 7. Eren M, Colak O, Isiksoy S, Yavuz A. Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux. Turk J Gastroenterol 2015;26:367-72.
  • 8. Schenk BE, Kuipers EJ, Klinkenberg-Knol EC, Eskes SA, Meuwissen SG. Helicobacter pylori and the efficacy of omeprazole therapy for gastroesophageal reflux disease. Am J Gastroenterol 1999;94:884-7.
  • 9. Labenz J, Blum AL, Bayerdorffer E, et al. Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis. Gastroenterology 1997;112:1442-7.
  • 10. Ribeiro PF, Kubrusly LF, Nassif PA, et al. Relationship between esophagitis grades and Helicobacter pylori. Arq Bras Cir Dig 2016;29:135-7.
  • 11. Moon A, Solomon A, Beneck D, Cunningham-Rundles S. Positive association between Helicobacter pylori and gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr 2009;49:283-8.
  • 12. Chourasia D, Misra A, Tripathi S, Krishnani N, Ghoshal UC. Patients with Helicobacter pylori infection have less severe gastroesophageal reflux disease:a study using endoscopy, 24-hour gastric and esophageal pH metry. Indian J Gastroenterol 2011;30:12-21.
  • 13. Nam SY. Helicobacter pylori has an inverse relationship with severity of reflux esophagitis. J Neurogastroenterol Motil 2011;17:267-73.

H. pylori gastriti ve mukozal özefajit arasında bir ilişki var mı?

Yıl 2019, , 14 - 18, 31.03.2019
https://doi.org/10.33204/mucosa.539459

Öz

 Amaç Gastroözofageal reflü hastalığı (GÖRH) ve H. pylori gastriti çocukluk çağında sık görülmektedir. Literatürde GÖRH olan hastalarda H. pylori enfeksiyonu insidansının % 30-90 arasında olduğu bildirilmiştir. İki hastalığın bir arada bulunması, günümüzde tartışılan konuların başında gelmektedir. Çalışmamızda; H. pylori gastriti olan ve olmayan çocuk hastalarda GÖRH prevelansını bulmayı ve H. pylori enfeksiyonunun GÖRH için bir risk faktörü olup olmadığını araştırmayı amaçladık.

Yöntem Çalışmaya Ocak 2009-Ocak 2019 arasında Karadeniz Teknik Üniversitesi Tıp Fakültesi Çocuk Gastroenteroloji, Hepatoloji ve Beslenme kliniğinde endoskopik inceleme yapılan hastalar dahil edildi. Hastaların verileri hastane dosyalarından geriye dönük olarak kaydedildi. Hastalar H. pylori enfeksiyonunun pozitif ve negatif olup olmamasına göre iki gruba ayrıldı. GÖRH sıklığı, endoskopi endikasyonları ve demografik özellikler karşılaştırıldı.

Bulgular 4337 hastanın (%55.5’i kız, ortalama yaş ±SD; 9.5±4.4 yıl, yaş aralığı; 6 ay-19 yıl), 348’inde (%8) GÖRH, 779’unda (%18) H. pylori gastiriti tespit edildi. H. pylori pozitif ve negatif olan hastalar arasında cinsiyet açısından anlamlı fark yoktu (p>0.05). H. pylori gastritinin daha büyük çocuklarda olduğu tespit edildi (p=0.000). H. pylori negatif hastalarda GÖRH prevalansı %8.4 iken H. pylori pozitif hastalarda %6.2 idi [OR,%0.71 95% CI (0.52-0.98), p=0.030].

Sonuç Çalışmamız H. pylori enfeksiyonunun GÖRH’de koruyucu bir rolü olduğunu göstermektedir. H. pylori eradikasyon tedavisinden sonra hastaların reflü semptomları değerlendirilememiştir. Bu nedenle ileriye dönük daha geniş spektrumlu çalışmalara ihtiyaç vardır.

Kaynakça

  • 1. Rosen R, Vandenplas Y, Singendonk M. et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendation of the North American Society for Pediatric Gastroenterology, Hepatology,and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. JPGN 2018;66:516-54.
  • 2. Nordenstedt H, Nilsson M, Johnsen R, Lagergren J, Hveem K. Helicobacter pylori infection and gastroesophageal reflux in a population-based study (The HUNT Study). Helicobacter 2007;12:16-22.
  • 3. Tanaka I, Tatsumi Y, Kodama T, et al. Effect of Helicobacter pylori eradication on gastroesophageal function. J Gastroenterol Hepatol 2004;19:251-7.
  • 4. Nwokolo CU, Freshwater DA, O’Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut 2003;52:637-40.
  • 5. Dominguez-Mu-oz JE, Malfertheiner P. Effect of Helicobacter pylori infection on gastrointestinal motility, pancreatic secretion and hormone release in asymptomatic humans. Scand J Gastroenterol 2001;36:1141-7.
  • 6. Wu JC, Sung JJ, Ng EK, et al. Prevalence and distribution of Helicobacter pylori in gastro-oesophageal reflux disease: a study from the East. Am J Gastroenterol 1999;94:1790-4.
  • 7. Eren M, Colak O, Isiksoy S, Yavuz A. Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux. Turk J Gastroenterol 2015;26:367-72.
  • 8. Schenk BE, Kuipers EJ, Klinkenberg-Knol EC, Eskes SA, Meuwissen SG. Helicobacter pylori and the efficacy of omeprazole therapy for gastroesophageal reflux disease. Am J Gastroenterol 1999;94:884-7.
  • 9. Labenz J, Blum AL, Bayerdorffer E, et al. Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis. Gastroenterology 1997;112:1442-7.
  • 10. Ribeiro PF, Kubrusly LF, Nassif PA, et al. Relationship between esophagitis grades and Helicobacter pylori. Arq Bras Cir Dig 2016;29:135-7.
  • 11. Moon A, Solomon A, Beneck D, Cunningham-Rundles S. Positive association between Helicobacter pylori and gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr 2009;49:283-8.
  • 12. Chourasia D, Misra A, Tripathi S, Krishnani N, Ghoshal UC. Patients with Helicobacter pylori infection have less severe gastroesophageal reflux disease:a study using endoscopy, 24-hour gastric and esophageal pH metry. Indian J Gastroenterol 2011;30:12-21.
  • 13. Nam SY. Helicobacter pylori has an inverse relationship with severity of reflux esophagitis. J Neurogastroenterol Motil 2011;17:267-73.
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Original Articles
Yazarlar

Elif Sag 0000-0003-3069-2872

Burcu Guven

Murat Cakir

Yayımlanma Tarihi 31 Mart 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

Vancouver Sag E, Guven B, Cakir M. Is there any relationship between H. pylori gastritis and mucosal esophagitis?. Mucosa. 2019;2(1):14-8.