Anogenital warts: an update on human papilloma virus, clinical manifestations and treatment strategies

Öz

Anogenital warts is a major health problem caused by human papillomavirus (HPV). To date, more than 200 subtypes of HPV exist.  Depending on the type of HPV and the immune status of the patient, various clinical forms may appear. The most detected types are HPV 6 and 11 which are responsible for approximately 90% of anogenital warts. High oncogenic strains HPV types 16 and 18 are responsible not only for servical cancer but also other cancers such as vagina, vulva, penis, anus, head and neck.   Besides, anogenital warts impact the individual’s quality of life leading significant psychosocial problems.  Treatment options for anogenital warts include cytodestructive,  immune-mediated and surgical therapies.  Treatment choice depends on the location, number, and size of the warts; patient situation (eg, pregnancy, ability to comply with therapy, immunsuppression); availability of clinical expertise; and patient preferences, cost, and convenience.   This article updates the epidemiological, etiological, clinical features and therapeutic choices in anogenital warts. 

Özet

 

Anahtar Kelimeler

• anogenital warts,hpv

Anogenital siğiller: İnsan papilloma virüsü, klinik bulguları ve tedavi stratejileri üzerine bir güncelleme

Öz

Anogenital siğiller insan papilloma virüsünün (HPV) neden olduğu önemli bir sağlık sorunudur. Bugüne kadar, 200’den fazla İPV saptanmıştır. HPV tipine ve hastanın bağışıklık durumuna bağlı olarak, anogenital siğillerde çeşitli klinik formlar gözlenebilir. En çok tespit edilen tipler HPV-6 ve HPV 11 olup anogenital siğillerin yaklaşık% 90'ından sorumludur. Yüksek onkojenik suşlar HPV tip 16 ve 18 sadece servikal kanserden değil, vajina, vulva, penis, anüs, baş ve boyun gibi diğer kanserlerden de sorumludur. Ayrıca, anogenital siğiller, bireyin yaşam kalitesini etkileyerek önemli psikososyal sorunlara neden olur. Anogenital siğiller için tedavi seçenekleri arasında desktrüktif, immün modülatör ve cerrahi tedaviler bulunmaktadır. Tedavi seçimi siğillerin yeri, sayısı ve büyüklüğüne; hastanın durumuna (örneğin, hamilelik, tedaviye uyma yeteneği, immün baskılama); klinisyenin tecrübesine; ve hastanın tercihleri ve rahatlığına bağlıdır. Bu makale anogenital siğillerdeki epidemiyolojik, etiyolojik, klinik özellikleri ve tedavi seçeneklerini güncellemektedir.

Anahtar Kelimeler

• anogenital siğil,human papillomavirüs

Kaynakça

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