Endometriyal Poliplerde Prolidaz Enzim Aktivitesi ve Oksidatif Stres ile İlişkisi

Öz

Endometrial polip (EP) kadın hastalıkları ve doğum kliniği pratiğinde sıklıkla karşılaşılan bir durumdur. Biz çalışmamızda endometrial polip tanısı olan hastaların prolidaz enzim aktivitesi ve oksidatif stres (OS) ile ilişkisini ortaya çıkarmayı amaçladık. Araştırmaya dahil edilme kriterlerini karşılayan histopatolojik olarak EP tanısı konan 35 hasta ile endometrial örnekleme sonucunda patoloji tespit edilmeyen 35 anormal uterin kanaması (AUK) olan kontrol grubu hastası dahil edilmiştir. EP ve kontrol grupları arasında TAS, TOS, OSI, prolidaz ve endometrium kalınlığı değerleri karşılaştırıldığında EP grubunda, kontrol grubuna göre TOS, OSI, prolidaz ve endometrial kalınlık değerleri istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur. Çalışmamız, daha geniş hasta grupları ile yapılan çalışmalarla desteklendiğinde patogenezin daha ayrıntılı anlaşılması ve klinik olarak hasta takibinde yararlı bir belirteç olabileceği görüşündeyiz.

Anahtar Kelimeler

• Endometrial Polip
• Oksidatif Stress
• Prolidaz Enzim Aktivitesi

Proje Numarası

This work was supported by the Muğla Sıtkı Koçman University Scientific Research Projects (Nu: 22/136/02/3/3).

Prolidase Enzyme Activity in Endometrial Polyps and Its Relationship with Oxidative Stress

Öz

Endometrial polyp (EP) is a condition that is often encountered in obstetrics and gynecology clinic practices. In our study, we aimed to reveal the relationship between prolidase enzyme activity (PEA) and Oxidative Stress (OS) in patients with endometrial polyps. Thirty-five patients who were histopathologically diagnosed with EP and 35 patients with abnormal uterine bleeding (AUB) without pathology as a result of endometrial sampling were included in the control group. Serum TOS, OSI, tissue PEA, and endometrial thickness values were found to be statistically significantly higher in the EP group compared to the control group. We believe that our study, when supported by studies with larger patient groups, may be a useful marker for a more detailed understanding of the pathogenesis and clinical follow-up of patients.

Anahtar Kelimeler

• Endometrial Polyp
• Oxidative Stress
• Prolidase Enzyme Activity

Destekleyen Kurum

This work was supported by the Muğla Sıtkı Koçman University Scientific Research Projects (Nu: 22/136/02/3/3).

Proje Numarası

This work was supported by the Muğla Sıtkı Koçman University Scientific Research Projects (Nu: 22/136/02/3/3).

Etik Beyan

I confirm that all methods were performed in accordance with the relevant guidelines. Ethical approval was obtained from the MSKU Faculty of Medicine Clinical Research Ethics Committee, Türkiye (Date: 06/01/2021, Decision no: 1/II).

Teşekkür

None

Kaynakça

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