Investigation of the Relationship Between HbA1c Levels and Inflammatory Markers

Öz

The purpose of our study is to evaluate the possible complications and treatment process in diabetic patients by examining the relationship between neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), C-reactive protein (CRP), sedimentation and Systemic Immun Inflamation Index (SII). The study included who had HbA1c tests taken from the outpatient and in hospital patients of Aydin Adnan Menderes University Hospital between January-August 2023. The demographic data and HbA1c, NLR, PLR, SII, sedimentation, CRP were recorded. Patients were divided into 3 groups as non-diabetic (HbA1c<6%), prediabetes (6–6.4%) and (≥6.5%) diabetic. The levels of various inflammation markers were compared between different patient groups. A statistically significant relation was identified between HbA1c levels and albumin (p<0.001), CRP (p=0.003), sedimentation (p<0.001), and NLR (p=0.021). Upon examination of the HbA1c groups as discrete categories, namely non-diabetes (<6), prediabetes (6-6.4) and diabetes (>6.5), at the level of non-diabetes and prediabetes a notable relation was observed between albumin (p=0.028), CRP (p=0.013) and sedimentation (p=0.014). Once more, a statistically significant relationship was identified between albumin (p<0.0001), CRP (p=0.013), sedimentation (p<0.0001) and NLR (p=0.020) in the non-diabetic and diabetic groups. No notable relation was identified between the prediabetes and diabetes groups and any of the inflammatory markers under investigation (p>0.05). The findings of our study indicate that in patients with diabetic (>6.5) or non-diabetic (<6) HbA1c, the use of NLR and SII as inexpensive and readily accessible inflammatory markers is a viable proposition.

Anahtar Kelimeler

• Diabetes Mellitus
• Hba1c
• Neutrophil Lymphocyte Ratio
• Platelet Lymphocyte Ratio

HbA1c Düzeyleri ile İnflamatuar Belirteçler Arasındaki İlişkinin Araştırılması

Öz

Çalışmamızın amacı, nötrofil lenfosit oranı (NLR), trombosit lenfosit oranı (PLR), C-reaktif protein (CRP), sedimantasyon ve sistemik immün inflamasyon indeksi (Sİİ) ile HbA1c düzeyleri arasındaki ilişkiyi inceleyerek diyabetli hastalarda olası komplikasyonları ve tedavi sürecini değerlendirmektir. Çalışmaya Ocak 2023 ile Ağustos 2023 tarihleri arasında Aydın Adnan Menderes Üniversitesi Hastanesi'nin ayaktan ve yatan hastalarından HbA1c testleri yaptıranlar dahil edildi. Demografik veriler ve HbA1c, NLR, PLR, SII, sedimantasyon, CRP kaydedildi. Hastalar diyabetsiz (HbA1c<6%), prediyabet (%6-6,4) ve (% ≥6,5) diyabetli olmak üzere 3 gruba ayrıldı. Çeşitli inflamasyon belirteçlerinin düzeyleri farklı hasta grupları arasında karşılaştırıldı. Bulgular: HbA1c düzeyleri ile albumin (p<0,001), CRP (p=0,003), sedimentasyon (p<0,001) ve NLR (p=0,021) arasında istatistiksel olarak anlamlı ilişki saptandı. HbA1c grupları diyabetsiz (<6), prediyabetli (6-6,4) ve diyabetli (>6,5) olmak üzere ayrı kategoriler halinde incelendiğinde diyabetsiz ve prediyabet düzeyinde albumin (p=0,028), CRP (p=0,013) ve sedimentasyon (p=0,014) arasında belirgin bir ilişki gözlendi. Yine diyabetsiz ve diyabetli gruplarda albumin (p<0,0001), CRP (p=0,013), sedimentasyon (p<0,0001) ve NLR (p=0,020) arasında istatistiksel olarak anlamlı bir ilişki saptandı. Prediyabet ve diyabet grupları ile araştırılan inflamatuar belirteçlerden herhangi biri arasında belirgin bir ilişki saptanmamıştır (p>0,05). Çalışmamızın bulguları, diyabetli (>6,5) veya diyabetli olmayan (<6) HbA1c'li hastalarda, NLR ve SII'nin ucuz ve kolay erişilebilir inflamatuar belirteçler olarak kullanılmasının uygulanabilir bir öneri olduğunu göstermektedir.

Anahtar Kelimeler

• Diabetes Mellitus
• Hba1c
• Nötrofil Lenfosit Oranı
• Trombosit Lenfosit Oranı

Kaynakça

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