Statin Kullanımının Erken(I-II) Evre Diz Osteoartriti olan Hastalarda Uygulanan PRP Tedavisinin Sonuçlarına Etkisi

Öz

Hem Statinlerin hem de PRP’(Plateletten Zengin Plazma) nin inflamasyon ve artrit süreci üzerine etikleri olduğunu gösteren çalışmalar mevcuttur. Çalışmamızın amacı statin kullanımının erken evre diz osteoartriti olan hastalarda uygulanan PRP tedavisinin klinik ve fonksiyonel sonuçları üzerine etkisinin incelenmesidir. Ocak 2018- Ağustos 2020 tarihleri arasında evre I-II diz osteoartriti nedeniyle PRP uygulanan tüm hastaların tıbbi kayıtları retrospektif olarak incelendi. Statin kullanmayan ve diz osteoartrit nedeniyle PRP tedavisi alan hastalar grup 1, hiperkolesterolemi nedeniyle statin kullanırken diz osteoartrit nedeniyle PRP tedavisi alan hastalar grup 2 olarak belirlendi. Hasta dosyaları taranarak hastaların demografik verileri, radyolojik görüntüleri ve klinik kayıtları retrospektif incelendi. İki grup arasında PRP tedavisinin klinik ve fonksiyonel etkisi karşılaştırıldı. Çalışmaya 40-70 yaş aralığında evre I-II diz osteoartriti olan toplam 70 hasta dahil edildi. Diz osteoartriti yaşam kalitesi ölçeği olan EQ5D5L’de PRP tedavisi öncesi iki grup arasında istatistiksel olarak anlamlı farklılık gözlenmiştir (p=0.036). Bunun dışında bakılan tüm parametrelerde anlamlı bir farklılık gözlenmemiştir. Çalışmamızda statin kullanımının PRP tedavisi üzerine pozitif veya negatif etkisi olup olmadığı araştırılmış; fonksiyonel ve klinik sonuçlar açısından anlamlı bir fark bulunmamıştır. Araştırmamızda PRP tedavisinin statin kullanımından bağımsız olarak hastaların klinik ve fonksiyonel değerlerinde artış sağladığı görüldü.

Anahtar Kelimeler

• Erken evre diz osteoartriti
• Gonartroz
• PRP
• Statin

Destekleyen Kurum

Çalışmamızda mali destek yoktur.

Etik Beyan

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Yazım Kurallarına uygun olarak hazırladığım bu araştırma makalesinde; • Makale içindeki bütün bilgileri etik davranış ve akademik kurallar çerçevesinde elde ettiğimi, • Makale çalışmasının hazırlık, bilgi, belge, veri toplama, analiz ve bilgilerin sunumu olmak üzere tüm aşamalarda bilimsel etik ve ahlak kurallarına uygun davrandığımı, • Makalede kullanılan tüm eserlere eksiksiz atıf yaptığımı ve kullanılan tüm eserlere kaynakçada yer verdiğimi, • Makalenin özgün olduğunu, •Makalenin hiçbir şekilde “intihal içermediğini” beyan eder, aksinin ortaya çıkması durumunda her türlü yasal sonucu kabullendiğimi bildiririm.

Teşekkür

Bu çalışmanın hazırlanması ve yürütülmesi sürecinde katkı ve desteklerini esirgemeyen değerli hocalarımız Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı mensuplarına şükranlarımızı sunarız.

The Impact of Statin Use on the Outcomes of Platelet-Rich Plasma (PRP) Therapy in Patients with Early (I–II) Stage Knee Osteoarthritis

Öz

There are studies indicating that both statins and Platelet-Rich Plasma (PRP) have effects on inflammation and the arthritis process. The aim of our study was to investigate the effect of statin use on the clinical and functional outcomes of PRP treatment in patients with early-stage knee osteoarthritis. Between January 2018 and August 2020, the medical records of all patients who underwent PRP treatment for stage I–II knee osteoarthritis were retrospectively reviewed. Patients who did not use statins and received PRP treatment for knee osteoarthritis were designated as Group 1, while patients who used statins for hypercholesterolemia and received PRP treatment for knee osteoarthritis were designated as Group 2. Patient demographics, radiological images, and clinical records were retrospectively analyzed. The clinical and functional effects of PRP treatment were compared between the two groups. A total of 70 patients aged 40–70 years with stage I–II knee osteoarthritis were included in the study. In the EQ5D5L quality of life scale, a statistically significant difference was observed between the two groups before PRP treatment (p = 0.036). No statistically significant difference was observed in any other parameters examined. Our study investigated whether statin use had a positive or negative effect on PRP treatment; no significant difference was found in terms of functional and clinical results. Regardless of statin use, PRP treatment was found to improve patients’ clinical and functional scores.

Anahtar Kelimeler

• Early stage knee osteoarthritis
• Gonarthrosis
• PRP
• Statin

Destekleyen Kurum

There is no financial support for our study.

Etik Beyan

I declare that in this research article, which I prepared in accordance with the Muğla Sıtkı Koçman University Medical Journal Writing Guidelines, I have: • Obtained all information in the article within the framework of ethical conduct and academic rules; • Acted in accordance with scientific ethics and moral principles at all stages of the article's preparation, information, documentation, data collection, analysis, and presentation; • I have fully cited all works used in the article and included all works in the bibliography; • The article is original; • The article is "plagiarism-free" in any way; and I accept all legal consequences should any finding to the contrary occur.

Teşekkür

We would like to express our gratitude to our esteemed professors, members of the Department of Orthopedics and Traumatology, Muğla Sıtkı Koçman University, Faculty of Medicine, for their contributions and support during the preparation and execution of this study.

Kaynakça

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