İleri Evre (Evre IIIC ve IV) Epitelial Over Kanserli Hastalarda Lenf Nodu Diseksiyonunun Sağkalıma Etkisi

Öz

Bu çalışmanın amacı, ileri evre (evre IIIC ve IV) primer epitelyal over kanseri nedeni ile primer sitoredüktif cerrahi uygulanan hastalarda sistematik retroperitoneal lenf nodu diseksiyonunun sağkalıma olan etkisini incelemektir. 1 Ocak 2003 ile 31 Aralık 2012 tarihleri arasında İzmir Tepecik Eğitim ve Araştırma Hastanesi Jinekolojik Onkoloji Kliniği'nde ileri evre primer epitelyal over kanseri tanısıyla primer sitoredüktif cerrahi uygulanmış 326 hastanın dosyası retrospektif olarak incelendi. Çalışmaya alınma kriterlerine uygun olan 208 hasta, primer sitoredüktif cerrahi ile eş zamanlı retroperitoneal lenf nodu diseksiyonu yapılmayanlar ve yapılanlar olmak üzere iki gruba ayrıldı. Hastaların genel ve hastalıksız dönem sağkalım süreleri incelendi. Lenfadenektomi yapılan grupta genel sağkalım süresinin daha yüksek olduğu bulundu. Ancak her iki grup arasında hastalıksız dönem sağkalım süreleri açısından anlamlı bir farklılık yoktu. Sistematik lenfadenektominin ileri evre over kanserli hastaların sağkalımına etkisi halen net olarak belirlenememiştir. Çalışmaların çoğunluğunda optimal debulkinge retroperitoneal lenfadenektomi eklenmesinin genel sağkalım süresini arttırdığı görülmesine rağmen bu bulguların prospektif çalışmalarla desteklenmesi gerekmektedir.

Anahtar Kelimeler

• Genel Sağkalım Süresi,İleri Evre Over Kanseri,Lenfadenektomi

The Effect of Lymph Node Dissection on Survival in Patients with Advanced Stage (Stage IIIC and IV) Ovarian Cancer

Öz

The aim of this study was to investigate the effect of systematic retroperitoneal lymph node dissection on survival in patients underwent primary cytoreductive surgery for advanced stage (stage IIIC and IV) primary epithelial ovarian cancer. The records of 326 patients who underwent primary cytoreductive surgery for advanced stage primary epithelial ovarian cancer between 01.01.2003 and 31.12.2012 in Gynecologic Oncology Clinic of Izmir Tepecik Training and Research Hospital were reviewed retrospectively. 208 patients, who met the inclusion criteria were divided into two groups as those performed with and without retroperitoneal lymph node dissection in addition to primary cytoreductive surgery. The overall survival and progression-free survival of the patients were evaluated. Overall survival was higher in the lymphadenectomy group. However, there was no significant difference between the two groups in terms of progression-free survival. The effect of systematic lymphadenectomy on survival of patients with advanced ovarian cancer remains unclear. Although the addition of retroperitoneal lymphadenectomy to the optimal debulking increases the overall survival in the majority of studies, these findings should be supported by prospective studies.

Anahtar Kelimeler

• vanced Stage Ovarian Cancer,Lymphadenectomy,Overall Survival

Kaynakça

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