The Effects of Preoperative Clinical and Radiological Results on the Prognosis in Patients Diagnosed with Oligodendroglioma

Yıl 2017, Cilt: 4 Sayı: 2, 1 - 5, 01.08.2017

Levent Fırat Derya Burcu Hazer Rosberg Ayça Erşen Danyeli Fadime Akman Gökmen Reyhanlı Mehmet Nuri Arda

Öz

Oligodendroglial
tumors are the third most common primary glial originated intracranial tumors.
According to the World Health Organization central nervous system
histopathological classification, Oligodendrogliomas are classified as Grade II
(classic) or Grade III (anaplastic). The aim of this study is to
retrospectively analyze the risk factors of recurrence during the follow- up
period of the patients who were diagnosed with Oligodendroglioma Grade II or
Grade III in our clinic. This study includes 18 patients who have been operated
in Dokuz Eylül University Medical Faculty Department of Neurosurgery between
2008 and 2013 with pathology results compatible with Grade II or Grade III
Oligodendroglioma. The study consisted of 12 males (66.7%) and 6 females (33.3%).
The average age of the patients was 45.22±11.41 (Age range: 26-65). 6 patients
(33.3%) were diagnosed with Oligodendroglioma (WHO Grade II), 12 (66.7%) with
Anaplastic Oligodendroglioma (WHO Grade III). When the subgroups, which were
divided into WHO Grade 2 and 3 by histopathological results, were compared
according to the radiological results, a significant statistical difference has
not been determined between calcification (p=0.596), midline shift (p=0,393),
tumor location (p=0.193), and death rate (0.193).  In the future bioindicators and molecular
studies will be used in the diagnosis and follow up of tumors and the risk
factors that cause recurrence will be defined in more details.

Anahtar Kelimeler

Anaplastic, Grade 2, Grade 3, Oligodendroglioma, Recurrence

Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi

Öz

Oligodendroglial tümörler en sık görülen üçüncü
intrakranyal glial hücre kökenli  primer
beyin tümörleridir. Oligodendrogliomlar Dünya Sağlık Örgütü (DSÖ) santral sinir
sistemi tümörlerinin histolojik sınıflandırmasına göre Derece 2 (klasik) veya
Derece 3 (anaplastik) olarak sınıflandırılmaktadır. Bu çalışmanın amacı
kliniğimizde oligodendrogliom tanısı alan hastaların takiplerinde rekürrense sebep
olan risk faktörlerinin retrospektif analizini yapmaktır. Bu çalışma 2008-2013
yılları arasında Dokuz Eylül Üniversitesi Tıp Fakültesi Beyin ve Sinir
Cerrahisi Kliniğinde ameliyat edilen ve patoloji sonucu Derece 2 ve 3
oligodendrogliom ile uyumlu olan 18 hastayı kapsamaktadır. Çalışmamızdaki
hastaların 12’si (% 66.7) erkek ve 6’sı (% 33.3) kadın idi. Hastaların başvuru
yaş ortalaması 45.22±11.41 (aralık 26-65) idi. Hastaların 6’sı  (% 33.3) oligodendrogliom (DSÖ derece
II),  12’si (%66.7) anaplastik oligodendrogliom
(DSÖ derece III) olarak değerlendirildi. Patoloji sonuçlarına göre DSÖ derece 2
ve derece 3 olarak ikiye ayrılan gruplar radyolojik görüntüler eşliğinde
karşılaştırıldığında; kalsifikasyon (p=0.600), orta hat şifti (p= 0.316), tümör
lokasyonu (p= 0.114) ve ölüm oranı (p= 0.114) arasında istatistiksel olarak
fark saptanmadı. Gelecekte biyobelirteçler ve moleküler çalışmalar tümör tanı
ve takibinde kullanılacak, rekürrense sebep olan risk faktörleri daha ayrıntılı
tanımlanacaktır.

Anahtar Kelimeler

Anaplastik, Derece 2, Derece 3, Oligodendrogliom, Rekürrens

Kaynakça

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