Vitiligo Hastalarında Topikal Kortikosterid Kulanımının Serum IL-17 Düzeyine Etkisi

Yıl 2018, Cilt: 5 Sayı: 3, 11 - 15, 04.12.2018

Sevim Karakaş Çelik , Nilgün Solak , Tuba Edgünlü Ümmühani Özel Türkçü

Öz

Vitiligo edinsel depigmentasyon
hastalıklarının en sık görüleni olup prevelansı %1-2’dir. Hastalık
melanositlerin kaybı ile oluşmaktadır. Yıllardır vitiligo patogenezini
açıklamaya yönelik biyokimyasal, immünolojik, genetik ve biyolojik çalışmalar
yapılmaktadır. Ancak bugüne kadar, vitiligonun etyopatogenezi ve mekanizmaları
tam olarak anlaşılamamıştır. Yakın zamana kadar vitiligo Th1 odaklı
otoimmuninflamatuar bir hastalık olarak kabul edilmekteydi. Ancak yapılan son
çalışmalar Th17’nin de vitiligo patogenezinde önemli bir rol aldığını ortaya
koymuştur. Vitiligo hastalarında IL-17 düzeyinin arttığı birçok çalışmada
gösterilmekle birlikte vitiligo hastalarında topikal kortikosteroid
kullanımının IL-17 düzeyine etkisini araştıran bir çalışma yapılmamıştır. Bu
çalışmada vitiligo hastalarında topikal kortikosteroid kullanımının IL-17 serum
düzeyine etkisinin belirlenmesi amaçlanmıştır. Çalışma kapsamında Bülent Ecevit
Üniversitesi Tıp Fakültesi Hastanesi Dermatoloji bölümünde kortikosteroid
tedavisi gören 68 vitiligo hastası ile herhangi bir tedavi almayan 16 vitiligo
hastasında serum IL-17 düzeyleri belirlenmiştir. Serum IL-17 düzeyleri topikal
kortikosteroid tedavisi alan ve almayan hastalar arasında karşılaştırıldığında
topikal kortikosteroid kullanımı ile serum IL-17 düzeyleri arasında anlamlı bir
ilişki bulunamamıştır (p>0.05). Daha önceki çalışmalarda vitiligo
hastalarında serum IL-17 düzeyinde farklılık görülmesi bu sitokinin vitiligo
patogenizinde rol oynadığını göstermekle birlikte çalışmamızda topikal
kortikosteroid kullanımının serum IL-17 düzeyine etki etmediği gösterilmiştir.

Anahtar Kelimeler

İnterlökin, IL-17, Serum Düzeyi, Sitokin, Vitiligo

The Effect of Topical Corticosteroids on Serum IL-17 Level in Vitiligo Patients

Öz

Vitiligo is
one of the most common acquired depigmenting disorders with a prevalence of
1-2% of population.  Vitiligo is caused
by the destruction of melanocytes. Over the years, the role of biochemical,
immunological, genetic, and other biological aspects in the pathogenesis of
vitiligo has been studied. So far, the exact etiopathogenesis and mechanisms of
vitiligo are not fully understood. Until recently vitiligo has been considered
mainly to be a Th1-driven autoimmune inflammatory disease defined but recent
findings have revealed a potential role for Th17 responses in the pathogenesis
of vitiligo. However, the results obtained in studies on serum levels of IL-17
are contradictory. In some studies, it has been found that increasing levels of
IL-17 in vitiligo patients but some studies decreased. The aim of our study is
to investigate serum levels of IL-17 in vitiligo patients in the Turkish
population. In the study, serum levels of IL-17 were determined in 68 vitiligo
patients who were treated with corticosteroids and 16 vitiligo patients without
any treatment in Dermatology department of Bülent Ecevit University Medical
Faculty Hospital. When serum IL-17 levels were compared between patients
receiving and not receiving topical corticosteroid treatment, no significant
correlation was found between serum IL-17 levels and topical corticosteroid use
(p>0.05). Although previous studies have shown that the difference in IL-17
serum levels that cytokine plays a role in the pathogenesis of vitiligo, but
our study indicates that topical steroid use in therapy has no effect on IL-17
levels.

Anahtar Kelimeler

Cytokine, IL-17, Interleukin, Serum Levels, Vitiligo

Kaynakça

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