Öz
Viral infections especially herpes virus and varicella zoster virus are common complications in patients with hematologic malignancies. The spectrum of infectious complications during and after dasatinib therapy are not known. I report here recurrent herpes labialis and herpes zoster infections in two chronic myeloid leukemia cases treated with dasatinib.
Anahtar Kelimeler
Dasatinib Herpes Labialis Herpes Zoster Chronic Myeloid Leukemia
Kaynakça
- 1. Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355(23):2408-17.
- 2. Brave M, Goodman V, Kaminskas E, et al. Sprycel for chronic myeloid leukemia and Philadelphia chromosome−positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clin Cancer Res. 2008;14:352-9.
- 3. Jabbour E, Cortes J, Kantarjian H. Dasatinib for the treatment of Philadelphia chromosome-positive leukaemias. Expert Opin Investig Drugs. 2007;16:679-87.
- 4. Fei F, Yu Y, Schmitt A, et al. Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens. Exp Hematol. 2008;36:1297-308.
- 5. Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999;340(17):1330-40.
- 6. Sunami Y, Sato E, Ichikawa K, et al. Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phase. Rinsho Ketsueki. 2011;52(5):282-6.
- 7. Garcia-Munoz R, Galar A, Moreno C, et al. Parvovirus B19 acute infection and a reactivation of cytomegalovirus and herpesvirus 6 in a chronic myeloid leukemia patient during treatment with dasatinib (BMS-354825). Leuk Lymphoma. 2007;48(12):2461-4.
- 8. Rodriguez GH, Ahmed SI, Al-akhrass F, et al. Characteristics of, and risk factors for, infections in patients with cancer treated with dasatinib and a brief review of other complications. Leuk Lymphoma. 2012;53(8):1530-5.
Öz
Viral enfeksiyonlar, özellikle herpes virüs ve varicella zoster virüs hematolojik malignitesi olan hastalarda en önemli komplikasyonlardır. Dasatinib kullanımı süresince ve sonrasında gelişecek enfeksiyöz komplikasyonların çeşitliliği bilinmemektedir. Burada dasatinib ile tedavi edilen iki kronik myeloid lösemi olgusunda tekrarlayan herpes labialis ve herpes zoster enfeksiyonu sunulmuştur.
Anahtar Kelimeler
Dasatinib Herpes Labialis Herpes Zoster Kronik Myeloid Lösemi
Kaynakça
- 1. Druker BJ, Guilhot F, O'Brien SG, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med. 2006;355(23):2408-17.
- 2. Brave M, Goodman V, Kaminskas E, et al. Sprycel for chronic myeloid leukemia and Philadelphia chromosome−positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clin Cancer Res. 2008;14:352-9.
- 3. Jabbour E, Cortes J, Kantarjian H. Dasatinib for the treatment of Philadelphia chromosome-positive leukaemias. Expert Opin Investig Drugs. 2007;16:679-87.
- 4. Fei F, Yu Y, Schmitt A, et al. Dasatinib exerts an immunosuppressive effect on CD8+ T cells specific for viral and leukemia antigens. Exp Hematol. 2008;36:1297-308.
- 5. Sawyers CL. Chronic myeloid leukemia. N Engl J Med. 1999;340(17):1330-40.
- 6. Sunami Y, Sato E, Ichikawa K, et al. Hemorrhagic colitis caused by dasatinib following cytomegalovirus enterocolitis in a patient with chronic myelogenous leukemia in the second chronic phase. Rinsho Ketsueki. 2011;52(5):282-6.
- 7. Garcia-Munoz R, Galar A, Moreno C, et al. Parvovirus B19 acute infection and a reactivation of cytomegalovirus and herpesvirus 6 in a chronic myeloid leukemia patient during treatment with dasatinib (BMS-354825). Leuk Lymphoma. 2007;48(12):2461-4.
- 8. Rodriguez GH, Ahmed SI, Al-akhrass F, et al. Characteristics of, and risk factors for, infections in patients with cancer treated with dasatinib and a brief review of other complications. Leuk Lymphoma. 2012;53(8):1530-5.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 10 Nisan 2023 |
| Gönderilme Tarihi | 26 Ekim 2021 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 10 Sayı: 1 |
