Vitamin D Role in Primary Dysmenorrhea

Yıl 2023, Cilt: 10 Sayı: 1, 58 - 61, 10.04.2023

Musa Büyük , Kamuran Suman , Ebru Gök , Pınar Bütün , Zafer Bütün , Murat Suman

https://doi.org/10.47572/muskutd.1148888

Öz

Primary dysmenorrhea is uterine cramping that occurs during or before menstruation without pelvic disease and causes suprapubic pain. In researching the causes of dysmenorrhea, several studies have highlighted the role of lacking vitamin D (vit D). Vit D acts by suppressing the synthesis of prostaglandins that cause pain. Our study aims to investigate whether vit D level affects primary dysmenorrhea. For this purpose, vit D 3 level will be studied in patients with primary dysmenorrhea and a control group without dysmenorrhea. This retrospective, randomized, case-controlled study was conducted between January 2020 and August 2021 at two different centers. It was approved by the ethics committee. Information was obtained by interviewing eligible subjects for the study, and informed consent was obtained. 750 women presented to the gynecology departments of the participating centers involved in the study. Ages between 16-35 are included in the study. Under 18 patients were referred from pediatric clinics with similar symptoms. 325 women were assigned to the dysmenorrhea group. All patients had a regular menstrual cycle and pain that began the day before menstruation. 325 patients unrelated to dysmenorrhea were selected randomly as a control group. The participants in our study were randomly selected into the dysmenorrhea group and the control group, and their clinical characteristics were compared in Tables 1 and 2. Significance was remarkable comparing the dysmenorrhea patients with the healthy control groups. That dysmenorrhea patients with 25-hydroxyvitamin D3 deficiency had significantly less consumption of dairy products. VAS values were higher, and undereducation and unemployment were also significantly more common. Low serum vit D levels and dysmenorrhea are strongly related. It is obvious that there is a significant relationship between vit D levels, VAS score, and primary dysmenorrhea. More studies at larger scales are needed to underline the efficiency of vit D in primary dysmenorrhea.

Anahtar Kelimeler

Vitamin D, Primary Dysmenorrhea, Dairy Products

Primer Dismenorede D Vitaminin Rolü

Öz

Primer dismenore, pelvik hastalık olmaksızın menstrüasyon sırasında veya öncesinde ortaya çıkan ve suprapubik ağrıya neden olan uterus kramplarıdır. Dismenore nedenlerini araştırırken, birkaç çalışma D vitamini (vit D) eksikliğinin rolünü vurgulamıştır. Vit D, ağrıya neden olan prostaglandinlerin sentezini baskılayarak etki eder. Çalışmamızın amacı D vitamini düzeyinin primer dismenoreyi etkileyip etkilemediğini araştırmaktır. Bu amaçla primer dismenoresi olan hastalarda ve dismenoresi olmayan kontrol grubunda vit D 3 düzeyi çalışılacaktır. Bu retrospektif, randomize, vaka kontrollü çalışma, Ocak 2020 ile Ağustos 2021 arasında iki farklı merkezde gerçekleştirildi. Etik kurul tarafından onaylandı. Bilgi, çalışma için uygun deneklerle görüşülerek elde edildi ve bilgilendirilmiş onam alındı. Araştırmaya katılan merkezlerin jinekoloji bölümlerine 750 kadın başvurdu. 16-35 yaş arası araştırmaya dahil edilmiştir. Pediatri kliniklerinden benzer semptomlarla 18 yaş altı hasta sevk edildi. 325 kadın dismenore grubuna atandı. Tüm hastalarda düzenli bir adet döngüsü ve adetten bir gün önce başlayan ağrı vardı. Dismenore ile ilgisi olmayan 325 hasta kontrol grubu olarak rastgele seçildi. Çalışmamızdaki katılımcılar dismenore grubu ve kontrol grubu olarak rastgele seçilmiş ve klinik özellikleri Tablo 1 ve 2'de karşılaştırılmıştır. Dismenore hastaları ile sağlıklı kontrol grupları karşılaştırıldığında anlamlılık dikkat çekiciydi. 25-hidroksivitamin D3 eksikliği olan dismenore hastalarının süt ürünlerini önemli ölçüde daha az tükettiği görülmüştür.Bu gurupta VAS değerleri daha yüksekti ve yetersiz eğitim ve işsizlik de önemli ölçüde daha yaygındı. Düşük serum D vitamini seviyeleri ve dismenore güçlü bir şekilde ilişkilidir. D vitamini düzeyleri, VAS skoru ve primer dismenore arasında anlamlı bir ilişki olduğu açıktır. Primer dismenorede vit D'nin etkinliğinin altını çizmek için daha büyük ölçeklerde daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler

D Vitamini, Primer Dismenore, Süt Ürünleri

Kaynakça

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