Araştırma Makalesi
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Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb

Yıl 2024, Cilt: 11 Sayı: 2, 110 - 113, 31.08.2024
https://doi.org/10.47572/muskutd.1482491

Öz

The bulbus oculi consists of two main fluid-containing anatomical structures: the aqueous humor (AH) at the anterior and the vitreous humor (VH) at the posterior. In this study, we investigated the diffusion changes that occur due to aging in these two structures with different biochemical contents using magnetic resonance imaging. VH and HA diffusion values were calculated in the eyes of a total of 128 patients divided into 8 different groups according to their ages. The results obtained were compared according to age, gender and right-left distinction. There was no statistically significant difference in the diffusion values obtained for both VH and HA between genders (p=0.397, p=0.383) and between right and left eyes (p>0.568, p>0.717). However, the first decade age group had the lowest diffusion values for both structures (p<0.001). Changes in the diffusion values of the eye in VH and HA due to aging show that the biochemical contents of both structures change with aging.

Kaynakça

  • 1. Hermsen VM, Dreyer RF. Ophthalmic anatomy. Prim Care. 1982;9(4):627-45.
  • 2. Benham GH, Duke-Elder WS, Hodgson TH. The osmotic pressure of the aqueous humour in the normal and glaucomatous eye. J Physiol. 1938;92(3):355-60.
  • 3. De Berardinis E, Tieri O, Polzella A, et al. The chemical composition of the human aqueous humour in normal and pathological conditions. Exp Eye Res. 1965;4(3):179-86.
  • 4. Goel M, Picciani RG, Lee RK, et al. Aqueous humor dynamics: a review. Open Ophthalmol J. 2010;4:52-9.
  • 5. Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res. 2000;19(3):323-44.
  • 6. Murthy KR, Goel R, Subbannayya Y, et al. Proteomic analysis of human vitreous humor. Clin Proteomics. 2014;11(1):29.
  • 7. Garg A, Rewri P. Comparison of aqueous humor ascorbic acid level in smokers and non-smokers. Exp Eye Res. 2023;226:109302.
  • 8. Jünemann AGM, Michalke B, Lucio M, et al. Aqueous humor selenium level and open-angle glaucoma. J Trace Elem Med Biol. 2018;50:67-72.
  • 9. Meral I, Bilgili Y. Diffusion changes in the vitreous humor of the eye during aging. AJNR Am J Neuroradiol. 2011;32(8):1563-6.
  • 10. Sebag J. To see the invisible: the quest of imaging vitreous. Dev Ophthalmol. 2008;42:5-28.
  • 11. Sebag J. Imaging vitreous. Eye (Lond). 2002;16(4):429-39.
  • 12. Gupta L, Peterson EL, Williams C, et al. Diffusion-weighted imaging of the orbit: a case series and systematic review. Ophthalmic Plast Reconstr Surg. 2023;39(5):407-18.
  • 13. Bammer R. Basic principles of diffusion-weighted imaging. Eur J Radiol. 2003;45(3):169-84.
  • 14. Le Bihan D, Breton E, Lallemand D, et al. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology. 1988;168(2):497-505.
  • 15. Hwang M, Shin SS, Thimm MA, et al. Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages. Clin Imaging. 2017;44:38-41.
  • 16. Charles-Edwards EM, deSouza NM. Diffusion-weighted magnetic resonance imaging and its application to cancer. Cancer Imaging. 2006;6(1):135-43.
  • 17. Kwee TC, Takahara T, Ochiai R, et al. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology. Eur Radiol. 2008;18(9):1937-52.
  • 18. Meier C, Dreher W, Leibfritz D. Diffusion in compartmental systems. I. A comparison of an analytical model with simulations. Magn Reson Med. 2003;50(3):500-9.
  • 19. Micevych PS, Horton JC. Postoperative magnetic resonance imaging of the inferior oblique muscle. J AAPOS. 2024;28(1):103826.
  • 20. Tsutsumi S, Kawai S, Sugiyama N, et al. Diameters of the optic sheath and superior ophthalmic vein can expand and contract at positional changes: a magnetic resonance imaging study. Surg Radiol Anat. 2024;46(2):153-8.
  • 21. Uysal C, Yilmaz T, Ozkan H, et al. The refractory secondary hyperparathyroidism presenting with retro-orbital brown tumor: a case report. BMC Nephrol. 2024;25(1):15.
  • 22. Kapur R, Sepahdari AR, Mafee MF, et al. MR imaging of orbital inflammatory syndrome, orbital cellulitis, and orbital lymphoid lesions: the role of diffusion-weighted imaging. AJNR Am J Neuroradiol. 2009;30(1):64-70.
  • 23. Politi LS, Forghani R, Godi C, et al. Ocular adnexal lymphoma: diffusion-weighted MR imaging for differential diagnosis and therapeutic monitoring. Radiology. 2010;256(2):565-74.
  • 24. Itakura H, Kishi S, Kotajima N, et al. Decreased vitreal hyaluronan levels with aging. Ophthalmologica. 2009;223(1):32-5.
  • 25. Zheng Y, Rao YQ, Li JK, et al. Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. Int J Ophthalmol. 2018;11(2):196-200.
  • 26. Toris CB, Yablonski ME, Wang YL, et al. Aqueous humor dynamics in the aging human eye. Am J Ophthalmol. 1999;127(4):407-12.
  • 27. Gabelt BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res. 2005;24(5):612-37.
  • 28. Inada K, Murata T, Baba H, et al. Increase of aqueous humor proteins with aging. Jpn J Ophthalmol. 1988;32(2):126-31.
  • 29. Gabelt BT, Gottanka J, Lütjen-Drecoll E, et al. Aqueous humor dynamics and trabecular meshwork and anterior ciliary muscle morphologic changes with age in rhesus monkeys. Invest Ophthalmol Vis Sci. 2003;44(5):2118-25.

Bulbus Okulinin Korpus Vitreumu ve Hümör Aközünde Yaşa Bağlı Difüzyon Değişiklikleri

Yıl 2024, Cilt: 11 Sayı: 2, 110 - 113, 31.08.2024
https://doi.org/10.47572/muskutd.1482491

Öz

Bulbus okuli, anteriorda hümör aköz (HA) ve posteriorda vitröz hümör (VH) olmak üzere iki ana sıvı içerikli anatomik yapıdan oluşur. Bu çalışmada, farklı biyokimyasal içeriğe sahip bu iki yapıda yaşlanmaya bağlı olarak oluşan difüzyon değişikliklerini manyetik rezonans görüntüleme kullanarak araştırdık Yaşlarına göre 8 farklı gruba ayrılan toplam 128 hastanın gözünde VH ve HA difüzyon değerleri hesaplandı. Elde edilen sonuçlar yaş, cinsiyet ve sağ-sol ayrımına göre karşılaştırıldı. Hem VH hem de HA için elde edilen difüzyon değerlerinde cinsiyetler arasında (p=0.397, p=0.383) ve sağ ve sol gözler arasında (p>0.568, p>0.717) istatistiksel olarak anlamlı fark saptanmadı. Ancak ilk dekat yaş grubu her iki yapı için de en düşük difüzyon değerlerine sahipti (p<0.001). Yaşlanmaya bağlı olarak gözün VH ve HA’de difüzyon değerlerinde meydana gelen değişiklikler, her iki yapının biyokimyasal içeriğinin yaşlanmayla birlikte değiştiğini göstermektedir.

Destekleyen Kurum

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Teşekkür

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Kaynakça

  • 1. Hermsen VM, Dreyer RF. Ophthalmic anatomy. Prim Care. 1982;9(4):627-45.
  • 2. Benham GH, Duke-Elder WS, Hodgson TH. The osmotic pressure of the aqueous humour in the normal and glaucomatous eye. J Physiol. 1938;92(3):355-60.
  • 3. De Berardinis E, Tieri O, Polzella A, et al. The chemical composition of the human aqueous humour in normal and pathological conditions. Exp Eye Res. 1965;4(3):179-86.
  • 4. Goel M, Picciani RG, Lee RK, et al. Aqueous humor dynamics: a review. Open Ophthalmol J. 2010;4:52-9.
  • 5. Bishop PN. Structural macromolecules and supramolecular organisation of the vitreous gel. Prog Retin Eye Res. 2000;19(3):323-44.
  • 6. Murthy KR, Goel R, Subbannayya Y, et al. Proteomic analysis of human vitreous humor. Clin Proteomics. 2014;11(1):29.
  • 7. Garg A, Rewri P. Comparison of aqueous humor ascorbic acid level in smokers and non-smokers. Exp Eye Res. 2023;226:109302.
  • 8. Jünemann AGM, Michalke B, Lucio M, et al. Aqueous humor selenium level and open-angle glaucoma. J Trace Elem Med Biol. 2018;50:67-72.
  • 9. Meral I, Bilgili Y. Diffusion changes in the vitreous humor of the eye during aging. AJNR Am J Neuroradiol. 2011;32(8):1563-6.
  • 10. Sebag J. To see the invisible: the quest of imaging vitreous. Dev Ophthalmol. 2008;42:5-28.
  • 11. Sebag J. Imaging vitreous. Eye (Lond). 2002;16(4):429-39.
  • 12. Gupta L, Peterson EL, Williams C, et al. Diffusion-weighted imaging of the orbit: a case series and systematic review. Ophthalmic Plast Reconstr Surg. 2023;39(5):407-18.
  • 13. Bammer R. Basic principles of diffusion-weighted imaging. Eur J Radiol. 2003;45(3):169-84.
  • 14. Le Bihan D, Breton E, Lallemand D, et al. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology. 1988;168(2):497-505.
  • 15. Hwang M, Shin SS, Thimm MA, et al. Apparent Diffusion Coefficient (ADC) of the vitreous humor and Susceptibility Weighted Imaging (SWI) of the retina in abused children with retinal hemorrhages. Clin Imaging. 2017;44:38-41.
  • 16. Charles-Edwards EM, deSouza NM. Diffusion-weighted magnetic resonance imaging and its application to cancer. Cancer Imaging. 2006;6(1):135-43.
  • 17. Kwee TC, Takahara T, Ochiai R, et al. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology. Eur Radiol. 2008;18(9):1937-52.
  • 18. Meier C, Dreher W, Leibfritz D. Diffusion in compartmental systems. I. A comparison of an analytical model with simulations. Magn Reson Med. 2003;50(3):500-9.
  • 19. Micevych PS, Horton JC. Postoperative magnetic resonance imaging of the inferior oblique muscle. J AAPOS. 2024;28(1):103826.
  • 20. Tsutsumi S, Kawai S, Sugiyama N, et al. Diameters of the optic sheath and superior ophthalmic vein can expand and contract at positional changes: a magnetic resonance imaging study. Surg Radiol Anat. 2024;46(2):153-8.
  • 21. Uysal C, Yilmaz T, Ozkan H, et al. The refractory secondary hyperparathyroidism presenting with retro-orbital brown tumor: a case report. BMC Nephrol. 2024;25(1):15.
  • 22. Kapur R, Sepahdari AR, Mafee MF, et al. MR imaging of orbital inflammatory syndrome, orbital cellulitis, and orbital lymphoid lesions: the role of diffusion-weighted imaging. AJNR Am J Neuroradiol. 2009;30(1):64-70.
  • 23. Politi LS, Forghani R, Godi C, et al. Ocular adnexal lymphoma: diffusion-weighted MR imaging for differential diagnosis and therapeutic monitoring. Radiology. 2010;256(2):565-74.
  • 24. Itakura H, Kishi S, Kotajima N, et al. Decreased vitreal hyaluronan levels with aging. Ophthalmologica. 2009;223(1):32-5.
  • 25. Zheng Y, Rao YQ, Li JK, et al. Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. Int J Ophthalmol. 2018;11(2):196-200.
  • 26. Toris CB, Yablonski ME, Wang YL, et al. Aqueous humor dynamics in the aging human eye. Am J Ophthalmol. 1999;127(4):407-12.
  • 27. Gabelt BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res. 2005;24(5):612-37.
  • 28. Inada K, Murata T, Baba H, et al. Increase of aqueous humor proteins with aging. Jpn J Ophthalmol. 1988;32(2):126-31.
  • 29. Gabelt BT, Gottanka J, Lütjen-Drecoll E, et al. Aqueous humor dynamics and trabecular meshwork and anterior ciliary muscle morphologic changes with age in rhesus monkeys. Invest Ophthalmol Vis Sci. 2003;44(5):2118-25.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Bünyamin Güney 0000-0002-0853-4184

Ferda Bacakszılar Sarı 0000-0002-6293-9481

Emrah Doğan 0000-0002-9446-2294

Yayımlanma Tarihi 31 Ağustos 2024
Gönderilme Tarihi 29 Mayıs 2024
Kabul Tarihi 21 Ağustos 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 11 Sayı: 2

Kaynak Göster

APA Güney, B., Bacakszılar Sarı, F., & Doğan, E. (2024). Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 11(2), 110-113. https://doi.org/10.47572/muskutd.1482491
AMA Güney B, Bacakszılar Sarı F, Doğan E. Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb. MMJ. Ağustos 2024;11(2):110-113. doi:10.47572/muskutd.1482491
Chicago Güney, Bünyamin, Ferda Bacakszılar Sarı, ve Emrah Doğan. “Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 11, sy. 2 (Ağustos 2024): 110-13. https://doi.org/10.47572/muskutd.1482491.
EndNote Güney B, Bacakszılar Sarı F, Doğan E (01 Ağustos 2024) Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 11 2 110–113.
IEEE B. Güney, F. Bacakszılar Sarı, ve E. Doğan, “Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb”, MMJ, c. 11, sy. 2, ss. 110–113, 2024, doi: 10.47572/muskutd.1482491.
ISNAD Güney, Bünyamin vd. “Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 11/2 (Ağustos 2024), 110-113. https://doi.org/10.47572/muskutd.1482491.
JAMA Güney B, Bacakszılar Sarı F, Doğan E. Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb. MMJ. 2024;11:110–113.
MLA Güney, Bünyamin vd. “Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, c. 11, sy. 2, 2024, ss. 110-3, doi:10.47572/muskutd.1482491.
Vancouver Güney B, Bacakszılar Sarı F, Doğan E. Age-Related Diffusion Changes in The Corpus Vitreum And Aqueous Humor of The Ocular Bulb. MMJ. 2024;11(2):110-3.