Objective: For the diagnosis, specific treatment and prevention of stone recurrence, it is important to determine the metabolic risk factors that play a role in the development of urinary system stone disease in children. The clinical, radiological and metabolic characteristics of children with urinary system stones were assessed in this study.
Methods: A retrospective study was conducted in the records of paediatric patients who applied to our pediatric outpatient nephrology clinic for various reasons between February 2018 and December 2023, diagnosed with urinary system stones.
Results: Of the 122 patients with a mean age of 4.40±4.16 years (1 month-17 years), 63 (51.6%) were boys and 59 (48.4%) were girls. In 61.4% of the children, a family history was identified. The most common presenting symptom was abdominal/flank pain or restlessness (47.5%). In 25.4% of the patients, the stones were ≤3 mm (microlithiasis) and most of the stones were located in the upper system. One or more metabolic abnormalities have been detected during urine analysis for 58.2% of patients. The most frequent metabolic abnormalities were hypercalciuria (20.5%) and hypocitraturia (17 2%). In 74.6% of patients, the size of stones decreased or completely disappeared with medical treatment based on underlying metabolic abnormalities and in 17.2% they did not change at all. Only eight (6.6%) patients required interventional procedures.
Conclusion: In all children with urinary tract stones, metabolic causes should be investigated first. The need for invasive stone procedures is reduced by special medical treatments designed to alter metabolism.
Childhood Urinary System Stone metabolic risk factors hypercalciuria hypocitraturia
Memorial Bahçelievler Hospital Ethics Committee, Approval Number: 114, Date: 2024-01-25.
Objective: To diagnose, treat, and prevent stone recurrence, it is important to determine the metabolic risk factors that play a role in developing urinary system stone disease in children. This study assessed children with urinary system stones’ clinical, radiological, and metabolic characteristics.
Material And Methods: A retrospective study was conducted on the records of pediatric patients who applied to our pediatric outpatient nephrology clinic for various reasons between February 2018 and December 2023 and were diagnosed with urinary system stones.
Results: Of the 122 patients with a mean age of 4.40±4.16 years (1 month-17 years), 63 (51.6%) were boys and 59 (48.4%) were girls. In 61.4% of the children, a family history was identified. The most common presenting symptom was abdominal/flank pain or restlessness (47.5%). In 25.4% of the patients, the stones were ≤3 mm (microlithiasis), and most stones were in the upper system. One or more metabolic abnormalities have been detected during urine analysis for 58.2% of patients. The most frequent metabolic abnormalities were hypercalciuria (20.5%) and hypocitraturia (17.2%). In 74.6% of patients, the size of stones decreased or completely disappeared with medical treatment based on underlying metabolic abnormalities, and in 17.2%, they did not change at all. Only eight (6.6%) patients required interventional procedures.
Conclusion: Metabolic causes should be investigated first in all children with urinary tract stones. Special medical treatments designed to alter metabolism reduce the need for invasive stone procedures.
Childhood Urinary System Stone metabolic risk factors hypercalciuria hypocitraturia
The study was approved by Ethics Committee of Memorial Bahçelievler Hospital (decision no: 114, date: 25.01.2024). The study protocol conformed to the ethical guidelines of the Helsinki Declaration.
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Birincil Dil | İngilizce |
---|---|
Konular | Klinik Tıp Bilimleri (Diğer) |
Bölüm | Araştırma Makalesi |
Yazarlar | |
Yayımlanma Tarihi | 29 Haziran 2024 |
Gönderilme Tarihi | 31 Mayıs 2024 |
Kabul Tarihi | 27 Haziran 2024 |
Yayımlandığı Sayı | Yıl 2024 Cilt: 19 Sayı: 2 |