DETERMINATION OF PROTEIN CARBONYL LEVELS IN PATIENTS WITH CHRONIC ALCOHOLICS AND EVALUATION TOGETHER WITH OTHER PARAMETERS

Öz

Investigation of the impact of oxidative stress, of which chronic alcohol consumption is an important indicator, on proteins and lipids. In this study, in order to evaluate oxidative damage, blood samples of 40 alcoholic patients, lying in the psychiatry clinic of Ankara University with the diagnosis of alcoholism, and 20 healthy people have been worked with spectrophotometric method. Malondialdehyde (MDA), lipid peroxidation product, and protein carbonyl (PCO) levels observed as statistically significantly higher, compared with the control group (p

Anahtar Kelimeler

• Malondialdehyde, Protein Carbonyl, Glutathione, Alcohol, DNA,

KRONYK ALKOLYK HASTALARDA PROTEYN KARBONYL SEVYYELERYNYN BELYRLENMESY VE DY?ER PARAMETRELERLE BYRLYKTE DE?ERLENDYRYLMESY

Öz

Çaly?mamyzyn amacy kronik alkol tüketiminin önemli bir göstergesi olan oksidatif stresin, protein ve lipitler üzerindeki etkisini ara?tyrmaktyr. Çaly?mada oksidatif hasary de?erlendirmek için alkolizm tanysy ile Ankara Üniversitesi psikiyatri klini?inde yatmakta olan 40 alkolik hasta ile sa?lykly 20 ki?inin kan örnekleri spektrofotometrik yöntemle çaly?ylmy?tyr. Lipid peroksidasyon ürünü olan Malondialdehit (MDA) (p

Anahtar Kelimeler

• Malondialdehit, Protein karbonil, Glutatyon, Alkol, DNA,