İNVAZİV MEME KARSİNOMU TANILI OLGULARDA İMMÜNOHİSTOKİMYASAL YÖNTEMLE MOLEKÜLER SUBTİPLENDİRME VE SUBTİPLERİN PROGNOSTİK FAKTÖRLERLE İLİŞKİSİ

Öz

Bu çalışmada, kliniğimizde invaziv meme karsinom tanısı almış 79 olgunun retrospektif olarak immünohistokimyasal boyanma profillerinin analizini yapmak yolu ile moleküler alt tiplerinin belirlenmesi (lüminal A, lüminal B, human epidermal büyüme faktörü reseptörü 2 (HER2) eksprese eden, bazal-like ve null tip) ve bu subtiplerin prognostik faktörlerle ilişkisinin değerlendirilmesi amaçlandı. Tüm olgulara ait seçilmiş tümör bloklarında immünohistokimyasal olarak, ER, PR, HER2 ve CK5/6 ekspresyonları değerlendirildi. En sık görülen histolojik tip invaziv duktal karsinomdu. Lüminal A, en sık moleküler subtipti. Lüminal A’ların çoğunun grade’i II iken, bazal-like tümörlerin tamamı grade III olarak bulundu. Grade I olguların çoğu lüminal A tipindeydi. Olguların yarısına yakınında tanı anında tümör çapı 2-5cm arasındaydı. Literatürle uyumlu olarak, 2cm’den küçük tümör oranı lüminal A tipte fazlaydı. 2 adet medüller karsinom olgusu literatürle uyumlu olarak bazal-like tip olarak bulundu. Bazal-like grupta tümör derecesi diğer tiplere göre daha yüksekti. İstatiksel olarak moleküler subtipler ve prognostik faktörlerle anlamlı ilişki saptanmadı. 

Anahtar Kelimeler

• Meme Karsinomu,Moleküler Subtip,İmmünohistokimya,Prognoz

MOLECULAR SUBTYPING IN CASES DIAGNOSED AS INVASIVE BREAST CARCINOMA BY IMMUNOHISTOCHEMICAL METHOD AND THE RELATIONSHIP BETWEEN SUBTYPES AND PROGNOSTIC FACTORS

Abstract

      In this study, we analyzed retrospectively by immunohistochemical staining profiles of molecular subtyping of 79 invasive breast carcinomas in our clinic. It is aimed to evaluate the relation between prognostic factors and these subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) overexpressing, basal-like and null type). Immunohistochemically, ER, PR, HER2 and CK5/6 expressions were evaluated in selected tumor blocks of all cases. The most common histological type was invasive ductal carcinoma. Luminal A was the most frequent subtype. While most luminal A tumors were grade II, most basal-like tumors were grade III. The majority of grade I tumors were luminal A. Nearly half of the patients had tumors between 2-5cm in diameter at diagnosis. Similar to the literature, tumors rate smaller than 2cm was higher in luminal A type. 2 medullary carcinoma cases were consistent with the literature found in the basal-like type. In basal-like group, the tumor grade was higher than in other groups. Significant relationship was not found statistically between molecular subtypes and prognostic factors. 

Keywords

• Breast Carcinoma,Molecular Subtype,Immunohistochemistry,Prognosis

Kaynakça

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