FREQUENCY OF HYDATIDIFORM MOLE IN CURETTAGE MATERIAL BETWEEN 2014 AND 2016 IN A UNIVERSITY HOSPITAL

Yıl 2018, Cilt: 13 Sayı: 3, 66 - 71, 23.07.2018

Yasemen Adalı , Hüseyin Avni Eroğlu , Gülname Fındık Güvendi , Rulin Deniz , Yakup Baykuş

Öz

     Gestational trophoblastic diseases show a spectrum
from benign and easily treatable conditions to malignancy. The disease that
remains in the most benign part of this distribution is the hydatiform mole
known as "grape gestation" among the population. There are two types
of mole hydatiform: partial and complete, and they are confronted at different
rates around the world. In our study, we aimed to determine the incidence of
hydatidiform mole at our hospital. 277 cases were included in our study that
came to our department of pathology which consists of abortion and pregnancy
termination materials between 2014-2016. Histopathologic examination revealed
mole hydatidiform in 19 of 277 cases (6.9%). Despite the need for genetic
analysis for definitive typing, 5.8% of cases were found to be partial mole and
1.1% complete according to histopathological findings. The etiologic factors of
molar pregnancies have not been fully elucidated. We think that frequency
studies can shed light on the future studies to determine these etiological
factors.

Anahtar Kelimeler

Mol Hydatiform, Partial, Complete, Gestational Trophoblastic Disease, Pregnancy

Kaynakça

• 1. Çiçek, M.N., Akyürek, C., Çelik, Ç. ve Haberal, A., (2004). Kadın Hastalıkları ve Doğum Bilgisi. 1. Baskı Ankara: Güneş Kitapevi. 491-87, 155-4, 153-49.
• 2. Beksaç, S., Demir, N., Koç, A. ve Yüksel, A., (2001). Maternal-Fetal Tıp & Perinatoloji. I. Baskı, İstanbul: Nobel Tıp Kitapevi, 60-58.
• 3. Kumar, V., Cotran, R. ve Robins, S., (2003). Temel Patoloji. 7. Baskı İstanbul: Nobel Tıp Kitabevi, 703, 1. Çeviri Edi. Prof.Dr. Uğur Çevikbaş.
• 4. Kumar, V., Abbas, A.K., Fausto, N., and Aster, J.K., (2010). Pathologic Basis of Disease. 8. Edition: Elsevier, 1058.
• 5. Ghaemmaghami, F. and Ashraf-Ganjooie, T., (2006). Gestational Trophoblastic Neoplasia. Asia-Pacific J. Clin Oncol, 2(1):9-21.
• 6. Hoffner, L. and Surti, U., (2012). The Genetics of Gestational Trophoblastic Aisease: A Rare Complication of Pregnancy. Cancer Genet. 205(3):63-77.
• 7. Ronnett, B.M., DeScipio, C., and Murphy, K.M., (2011). Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis. Int J Gynecol Pathol. 30(2):101-16.
• 8. Davis, J.R., Surwit, E.A., Garay, J.P., and Fartier, K.J., (1984). Sex assigment in Gestational Trophoblastic Neoplasia. Am J Obstet Gynecology, 148(6):722-5.
• 9. Altieri, A., Franceschi, S., Ferlay, J., Smith, J., and La Vecchia, C., (2003). Epidemiology and Aetiology of Gestational Trophoblastic Diseases. Lancet Oncol, 4(11):670-8.
• 10. Hayashi, K., Bracken, M.B., Freeman DH, J., and Hellenbrand, K., (1982). Hydatidiform mole in United States (1970-1977): A Statistical and Theoretical Analysis. Am J Epidemiol, 115(1):67-77.
• 11. Ghaemmaghami, F. and Ashraf-Ganjooie, T., (2006). Gestational Trophoblastic Neoplasia. Asia-Pacific J Clin Oncol, 2(1):9-21.
• 12. Srivannaboon, S., Vatananusara, C., and Boonyanit, S., (1974). The Incidence of Trophoblastic Disease in Siriraj Hospital. J Med Assoc Thai, 57(11):537-42.
• 13. Sun, S.Y., Amed, A.M., Bertini, A.M., and Camano, L., (1992). Incidence of Hydatidiform mole at the Paulista Medical School. Rev Assoc Med Bras. 1992 Oct-Dec, 38(4):217-20.
• 14. Biscaro, A., Silveira, S.K., Locks Gde, F., Mileo, L.R., da Silva Júnior, J.P., and Pretto, P., (2012). Frequency of Hydatidiform Mole in Tissue Obtained by Curettage. Rev Bras Ginecol Obstet. 34(6):254-8.
• 15. Mourali, M., Fkih, C., Essoussi-Chikhaoui, J., Ben Haj Hassine, A., Binous, N., Ben Zineb, N., and Boussen, H., (2008). Gestational Trophoblastic Disease in Tunisia. Tunis Med. 86(7):665-9.
• 16. Bianconi, M.I., Otero, S., Moscheni, O., Alvarez, L., Storino, C., and Jankilevich, G., (2012). Gestational Trophoblastic Disease: a 21- Year Review of the Clinical Experience at an Argentinean Public Hospital. J Reprod Med. 57(7-8):341-9.
• 17. Ocheke, A.N., Musa, J., and Uamai, A.O., (2011). Hydatidiform Mole in Jos, Nigeria. Niger Med J. 52(4):223-6.
• 18. Clark, R.M., Nevadunsky, N.S., Ghosh, S., Goldstein, D.P., and Berkowitz, R.S., (2010). The Evolving Role of Hysterectomy in Gestational Trophoblastic Neoplasia at the New England Trophoblastic Disease Center. J Reprod Med. 55(5-6):194-8.
• 19. Yumru, A.E., Dincgez, B., Öndeş, B., and Bozyiğit, A., (2012). Epidemiologic Characteristics and Management of Subjects Who Were Diagnosed with Trophoblastic Disease. Erciyes Med. J. 34(3):106-10.
• 20. Eren, S., Demirci, F., Uludoğan, M., Göç, M., and Sofuoğlu, K., (1992). Clinical Evaluation of 154 Cases with Gestational Trophoblastic Disease. SCIE. 3(3):319-321.
• 21. Çetin, M., Balta, Ö., Duran, B., Güvenal, T. ve Yanar, O., (2004). Kliniğimize Başvuran Mol Gebelik Olgularının Retrospektif İncelenmesi. Cumhuriyet Üniversitesi Tıp Fakültesi Dergisi. 26(1):18–22.
• 22. Solmaz Hasdemir, P., Özçakır, H.T., Oruç Koltan, S. ve Güvenal, T., (2014). Bir Üniversite Hastanesinde Gestasyonel Trofoblastik Hastalık Olgularının Değerlendirilmesi. Türk Jinekolojik Onkoloji Dergisi. Sayfa 134-137.
• 23. Budak, M.Ş., Kaya, C., Şentürk, M.B., Akgol, S., Kanat Pektaş, M., Yaman Tunç, S. ve Göklü, M.R., (2016). Kliniğimizde Tanı Alan Parsiyel ve Komplet Mol Hidatiform Olgularının Retrospektif Analizi. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi, 56(2).
• 24. Kars, B., Taşlıgedik, G., Karageyim Karşıdağ, Y., Büyükbayraklı, E.E., Pirimoğlu, Z.M., Sargın, M. ve et al., (2011). 2005-2009 Yılları Arasında Molar Gebelik Nedeniyle Tedavi Olan Hastaların Takibi ve Değerlendirilmesi. Türk Jinekolojik Onkoloji Dergisi. 1(1):26-32.