THE EFFECTS OF TOXOPLASMA GONDII INFECTIONS ON ANXIETY, DEPRESSION AND LEARNING IN OFFSPRINGS OF INFECTED PARENTS

Yıl 2019, Cilt: 14 Sayı: 1, 33 - 45, 31.01.2019

Erol Ayaz Hayriye Orallar Kerem Yaman Ayhan Çetinkaya Bihter Gökçe Bozat Mücahit Çakmak Enes Eğilmez

Öz

      Toxoplasma Gondii is
a zoonotic parasite showing intracellular localization. Although it doesn’t
select a specific region in the brain tissue, the cyst forms occurring in the
chronic phase may cause behavioral changes when it is located in the brain
regions related to behavior. The aim of this study is to investigate whether
there is a relationship between neurodegenerative and neuropsychiatric diseases
caused by antibodies transmitted to the first generation of T.Gondii infection
by behavioral tests. In this study, using a total of 24 female and 6 male rats.
Behavioral tests have been applied to F1 generation groups female and male. In
this study, female rats with chronic T.Gondii infection have been found to have
increased anxiety in open field in the first generation male offsprings and
decreased locomotor activity. Increased mobility in male offsprings has been
observed in the elevated plus maze test. In female offspring, it has reduced
anxiety and depression. 

Anahtar Kelimeler

Toxoplasma Gondii, Behavior, Anxiety, Memory, Learning

THE EFFECTS OF TOXOPLASMA GONDII INFECTIONS ON ANXIETY, DEPRESSION AND LEARNING IN OFFSPRINGS OF INFECTED PARENTS

Öz

Toxoplasma Gondii is a zoonotic parasite showing intracellular localization. Although it doesn’t select a specific region in the brain tissue, the cyst forms occurring in the chronic phase may cause behavioral changes when it is located in the brain regions related to behavior. The aim of this study is to investigate whether there is a relationship between neurodegenerative and neuropsychiatric diseases caused by antibodies transmitted to the first generation of T.Gondii infection by behavioral tests. In this study, using a total of 24 female and 6 male rats. Behavioral tests have been applied to F1 generation groups female and male. In this study, female rats with chronic T.Gondii infection have been found to have increased anxiety in open field in the first generation male offsprings and decreased locomotor activity. Increased mobility in male offsprings has been observed in the elevated plus maze test. In female offspring, it has reduced anxiety and depression

Anahtar Kelimeler

Toxoplasma Gondii, Behavior, Anxiety, Memory, Learning

Kaynakça

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