Evaluation of Homocysteine and Vitamin D Levels in Osteoarthritis Patients

Yıl 2021, Cilt: 16 Sayı: 2, 68 - 73, 28.04.2021

Gürkan Çıkım , Ülkü Veranyurt

Öz

In this study, we aimed to investigate whether there is a change in the levels of vitamin D, vitamin B12, folic acid, which are important for metabolism, and homocysteine levels, which are considered to be an indicator of oxidative stress, in women with osteoarthritis. This study was conducted on 30 women with osteoarthritis (Group I) and 30 healthy women (Group II) who applied to the orthopedic outpatient clinic in Kahramanmaraş Necip Fazıl City Hospital between January and December 2020. Plasma homocysteine, serum folic acid, vitamin B12 and vitamin D levels were evaluated in the study. In homocysteine levels; a statistically significant increase was found in the group with osteoarthritis (Group I) (p<0.05). In folic acid, vitamin B12, vitamin D levels; a statistically significant decrease was detected in the group with osteoarthritis (Group I) (p<0.05). In conclusion, we think that folic acid, which provide homocysteine excretion; vitamin B12 and vitamin D levels that contribute to the development of OA should be followed up and added to the diet in case of deficiency in patients with OA or joint disease that reduce the quality of life.

Anahtar Kelimeler

Osteoartrit, Homosistein, D Vitamin, Vitamin B12, Folik Asit

Proje Numarası

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Kaynakça

• Sacitharan, P.K., (2019). Ageing and osteoarthritis. Biochemistry and Cell Biology of Ageing: Part II Clinical Science, 123-159.
• Pereira, D., Ramos, E., and Branco, J., (2015). Osteoartrite. Acta Med Port, 28(1):99-106.
• Dawson, J., Linsell, L., Zondervan, K., et al., (2004). Epidemiology of hip and knee pain and its impact on overall health status in older adults. Rheumatology, 43:497-504.
• Woolf, A.D. and Pfleger, B., (2009). Burden of major musculoskeletal conditions. Bull World Health Organ, 81:646-56.
• Guler Uysal, F. and Başaran, S., (2009). Kneeoteoarthritis turl j phys med rehab. 55 Suppl 1:1-7.
• Heijink, A., Vanhees, M., van den Ende, K., van den Bekerom, M. P., van Riet, R. P., Van Dijk, C. N., and Eygendaal, D., (2016). Biomechanical considerations in the pathogenesis of osteoarthritis of the elbow. Knee Surgery, Sports Traumatology, Arthroscopy, 24(7):2313-2318.
• Nelson, A.E., (2018). Osteoarthritis year in review 2017: clinical. Osteoarthritis and cartilage, 26(3):319-325.
• Abramoff, B. and Caldera, F.E., (2019). Osteoarthritis: pathology, diagnosis, and treatment options. The Medical Clinics of North America, 104(2):293-311.
• Osteoarthritis Research Society International, (2016). Osteoarthritis: A Serious Disease. Osteoarthritis Research Society International, 1:103.
• King, L.K., Kendzerska, T., Waugh, E.J., and Hawker, G.A., (2018). Impact of osteoarthritis on difficulty walking: a population‐based study. Arthritis care & Research, 70(1):71-79.
• Jakubowski, H., (2017). Homocysteine editing, thioester chemistry, coenzyme a, and the origin of coded peptide synthesis. Life, 7(1):6.
• Ganguly, P. and Alam, S.F., (2015). Role of homocysteine in the development of cardiovascular disease nutr j. 10(14):6.
• Van Guldener, C. and Stehouwer, C.D., (2005:May). Homocysteine and methionine metabolism in renal failure. In seminars in vascular medicine. 5(2):201-208. Copyright© 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001 USA.
• Perna, A.F. and Ingrosso, D., (2019). Homocysteine and chronic kidney disease: an ongoing narrative. J Nephrol, 32(5):673-675.
• Ma, C.H., Chiua, Y.C., Wu, C.H., Jou, I.M., Tu, Y.K., Hung, C.H., and Tsai, K.L., (2018). Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: a possible link between hyperhomocysteinemia and osteoarthritis. Redox Biology, 15:504-512.
• Herrmann, M., Farrell, C.J.L., Pusceddu, I., Fabregat-Cabello, N., and Cavalier, E., (2017). Assessment of vitamin D status–a changing landscape. Clinical Chemistry and Laboratory Medicine (CCLM), 55(1):3-26.
• Sun, J., (2018). Dietary vitamin D, vitamin D receptor, and microbiome. Current Opinion in Clinical Nutrition and Metabolic Care, 21(6):471.
• Sempos, C.T., Vesper, H.W., Phinney, K.W., Thienpont, L.M., Coates, P.M., and Vitamin D Standardization Program (VDSP), (2012). Vitamin D Status as an international issue: national surveys and the problem of standardization. Scandinavian Journal of Clinical and Laboratory Investigation, 72(sup243):32-40.
• Jamka, M., Ruchała, M., and Walkowiak, J., (2019). Vitamin D and hashimoto's disease. Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego, 47(279):111-113.
• Feldman, D., Krishnan, A.V., Swami, S., Giovannucci, E., and Feldman, B.J., (2014). The role of Vitamin D in reducing cancer risk and progression. Nature Reviews Cancer, 14(5):342-357.
• Felson, D.T., (2009). Developments in the clinical understanding of osteoarthritis. Arthritis Research and Therapy. 11(1):1-11.
• Van Meurs, J.B.J. and Uitterlinden, A.G., (2012). Osteoarthritis year 2012 in review: genetics and genomics. Osteoarthritis and Cartilage, 20(12):1470-1476.
• Woolf, A.D. and Pfleger, B., (2003). Burden of major musculoskeletal conditions. Bulletin of the World Health Organization, 81:646-656.
• McDowell, I.F. and Lang, D., (2000). Homocysteine and endothelial dysfunction: a link with cardiovascular disease. The Journal of Nutrition. 130(2):369S-372S.
• Mistry, D., Chambers, M.G., and Mason, R.M., (2006). The Role of adenosine in chondrocyte death in murine osteoarthritis and in a murine chondrocyte cell line. Osteoarthritis and Cartilage, 14(5):486-495.
• Johnson, S.M., Patel, S., Bruckner, F.E., and Collins, D.A., (1999). 5'-Nucleotidase as a marker of both general and local inflammation in rheumatoid arthritis patients. Rheumatology, 38(5):391-396.
• Bikle, D., (2009). Nonclassic actions of Vitamin D. J Clin. Endocrinol. Metab. (94):26–34.
• Wu, Z., Malihi, Z., Stewart, A.W., Lawes, C.M., and Scragg, R., (2016). Effect of Vitamin D supplementation on pain: a systematic review and meta-analysis. Pain Physician, 19(7):415-427.
• Tetlow, L.C. and Woolley, D.E., (2001). Expression of Vitamin D receptors and matrix metalloproteinases in osteoarthritic cartilage and human articular chondrocytes in vitro. Osteoarthritis and Cartilage, 9(5):423-431.