TİYOSEMİKARBAZON VE METAL KOMPLEKSLERİNİN RATLARDA SERUM AMİNO ASİT DÜZEYLERİNE ETKİSİ

Öz

Tiyosemikarbazon ve Schiff bazlarının çeşitli türevleri ve bunların metal kompleksleri antitümör, antineoplastik, antiviral, antibakteriyel, antimalarial gibi biyolojik fonksiyonlarından dolayı kimya, biyoloji ve farmakoloji bilim dallarında büyük ilgi görmektedir. Ayrıca bu bileşiklerin yapı aktivite ilişkisi (QSAR) araştırmaları birçok çalışmaya konu olmaktadır. Bu çalışmada, Tiyosemikarbazon türevi bileşiklerin ve metal komplekslerinin serum amino asit düzeylerine etkisi incelendi. Yapılan çalışmalar sonucunda, bileşiklerin serum amino asit düzeylerini azalttığı görülmüştür.

Anahtar Kelimeler

• Tiyosemikarbazon, metal kompleksi, serum, amino asit, rat,

SERUM AMINO ACID LEVELS WITH THIOSEMICARBAZONE DERIVATIVES AND ITS METAL COMPLEXES TREATED RATS

Abstract

Thiosemicarbazone (TSC) and Schiff base (SB) derivatives have raised considerable interest in chemistry, biology and pharmacology due to their antitumor, antibacterial, antimalarial, antineoplastic and antiviral activities. In addition, many studies have focused on qualitative structure activity relationship (QSAR) of the compounds. In this study, effects of the serum free amino acid level of the thiosemicarbazone and its metal complexes on rats. Our findings indicate that all compounds were decreased serum amino acid levels.

Keywords

• Thiosemicarbazone, metal complex, serum, amino acid, rat,

Kaynakça

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