THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN

Abstract

Melatonin (N-acetyl-5-methoxytryptamine),the main secretory product of the pineal gland, is a free radical scavenger that has been found to protect against lipid peroxidation in many experimental models. In the present many study the effect of melatonin on lipid peroxidation of long chain polyunsaturated fatty acids located in rat. The most sensitive fatty acids in the heart were the monounsaturated eicosenoik acid (C20:1 n-6), polyunsaturated arachidonic acid (C20:4 n-6) docosapenthonoic acid (C22:5 n-3) and docosahexanoic acid (C22:6 n-3) which compared with the corresponding control values. I/R performed group showed remarkable differerences (p<0.05).In this study, myokardial-iscemia reperfusion is determined to cause increase or decreasa in different types of fatty acids.

Keywords

• Melatonin, Myocardial Ischemia-Reperfusion, Tissues, Fatty acids, Gas Chromatography

SIÇANLARIN KALP DOKULARINDA YAĞ ASİTLERİ DÜZEYLERİNİN I/R VE MELATONİN UYGULAMALARIYLA DEĞİŞİMLERİNİN İNCELENMESİ

Öz

Melatonin- beyin epifizinin ana ürünü olan salgısı-birçok deneyde yağ peroksidasyonuna karşı savaşan serbest radikal bir temizleyici olduğu gözlemlendi. Mevcut birçok çalışmalarda-farede yapılan-melatoninin çoklu doymamış yağ asitlerine etkisi olduğu belirlendi. Araşidonik asit (C20:4 n-6) dokosapentaenoik asit (C22:5 n-3, tekli doymamış yağ asitleri, eicosenoik asit (C20:1 n-6)ve dokosaheksaenoik asit (C22:6 n-3) karşılık gelen kontrol değeri ile karşılaştırıldı. I/R çalışılan grup büyük farklılıklar gösterdi. Bu çalışmada miyokardiyal iskemi reperfüzyonunun farklı yağ asitleri türlerinde artmalara veya azalmalara sebep olduğu belirlendi

Anahtar Kelimeler

• Melatonin, Miyokardiyal İskemi Reperfüzyon

Kaynakça

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