BAZI PİRİDİL-SÜBSTİTÜE SCHIFF BAZLARININ HAZIRLANMASI VE Tc-99m İLE ETİKETLENMESİ

Yıl 2013, Cilt: 8 Sayı: 4, 32 - 40, 01.05.2013

Fikret Büyükkaya Şeniz Kaban

Öz

Bu çalışmada bazı piridil-substitue Schiff bazlarının sentezi, karakterizasyonu ve Tc-99m ile etiketlenmesi sunulmaktadır. Piridin-2-aldehit bileşiğinin, aminofenol, anilin ve aminopiridin türevi bileşikler ile kondenzasyon reaksiyonlarından onbir adet heterosiklik Schiff bazı sentezlenmiştir. Tüm bu bileşiklerin yapıları, ultraviyole (UV), infrared (IR), nükleer magnetik rezonans (NMR) ve kütle spektral (MS) verilerinden yararlanılarak belirlenmiştir. Schiff bazı türevleri Tc-99m ile etiketlenmiş ve radyokimyasal saflık kromatografik yöntemler kullanılarak (TLC, HPLC) hesaplanmış ve oluşturulan kromatogramlar TLC görüntüleme ve gama sayıcı cihazları yardımıyla değerlendirilmiştir.

Anahtar Kelimeler

Schiff bazı, Piridin-2-aldehit, Tc-99m, Etiketleme, Radyofarmasötik,

PREPARATION OF SOME PYRIDYL-SUBSTITUTED SCHIFF BASES AND THEIR LABELLING WITH Tc-99m

Öz

This work presents synthesis and characterization of the some pyridyl-substituted Schiff bases and their labeling with Tc-99m. The eleven heterocyclic Schiff bases have been synthesized from the condensation reactions of pyridine-2-aldehyde with derivative of aminophenol, aniline and aminopyridine compounds. Structure of all synthesized compounds have been determined by using the data obtained from their ultraviolet (UV), infrared (IR), nuclear magnetic resonance (NMR) and mass (MS) spectral results. Schiff base derivatives of pyridine-2-aldehyde were labeled with Tc-99m and their radiochemical purity was calculated by using chromatographic methods (TLC and HPLC); and obtained chromatograms have been evaluated by TLC scintigraphy system and gamma counters.

Anahtar Kelimeler

Schiff base, Pyridine-2-aldehyde, Tc-99m, Labeling, Radiopharmaceutical,

Kaynakça

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