THE EFFECTS OF 5,5'-BUTANE-1,4-DIYLBIS[4-ALLYL-2-({4-[3- (TRIFLUOROMETHYL)PHENYL]PIPERAZIN-1-YL}METHYL)- 2,4-DIHYDRO-3H-1,2,4- TRIAZOLE-3-THIONE] COMPOUND ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS

Yıl 2015, , 14 - 20, 07.04.2015

Naci Alayunt Sait Çelik Metin Koparır Mustafa Karatepe

https://doi.org/10.12739/NWSA.2015.10.2.3A0068

Öz

The 1,2,4-triazole along with its derivatives were reported to exhibit various pharmacological activities [1]. 1,2,4-triazole moieties have been incorporated into a wide variety of therapeutically interesting drug candidates, including anti-inflammatories, CNS stimulants, sedatives, anti-anxiety compounds, antimicrobial agents, as well as anti-mycotic ones such as fluconazole, intraconazole andvoriconazole [2]. As previously reported, Aminomethyl derivatives were synthesized. In this study, the effects of newly synthesized bis1,2,4-triazole containing aminomethyl derivatives on the level of malondialdehyde(MDA)and antioxidant vitamins (A,E,C) of the serum, liver and kidney of rats have been investigated. In addition, level of malondialdehyde (MDA) and vitamins (A,E,C) has been determined by HPLC [3]. Most of the compounds showed satisfactory performance when compared to the control group [4]

Anahtar Kelimeler

1, 2, 4-Triazole, Aminomethyl Derivative, Vitamin

5,5'-BÜTAN-1,4-DIILBIS[4-ALLIL-2-({4-[3 (TRIFLOROMETIL)FENIL]PIPERAZIN-1-IL}METIL)-2,4-DIHIDRO-3H-1,2,4- TRIAZOL-3-TIYON BİLEŞİĞİNİN FARELERİN BÖBREK, KARACİĞER VE SERUMLARINDAKİ MDA VE VİTAMİN DÜZEYLERİNE ETKİSİ

Öz

1,2,4-triazol türevleri çeşitli farmakolojik aktivite gösterdikleri bilinmektedir. flukonazol, intraconazole, vorikonazol gibi 1,2,4-triazol türevleri içeren kısımlar çeşitli uyuşturucu ve
terapötik ilaçlar da dahil olmak üzere anti-enflamatuar, CNS uyarıcılar, yatıştırıcılar, sakinleştirici maddeler, antibiyotik antimikotik etkilere sahiptir. Kullanılan aminometil türevi daha önce bildirildiği gibi yeniden sentezlendi. Bu çalışmada, yeni sentezlenmiş bis-1,2,4-triazol içeren aminometil türevi bileşik rat serum, karaciğer ve böbrek dokularında malondialdehit(MDA)ve antioksidan vitamin (A,E,C)düzeyleri incelendi. Malondialdehit düzeyi (MDA) ve vitaminler (A,E,C) HPLC cihazı kullanılarak belirlendi. L bileşiği kontrol ile karşılaştırıldığında iyi aktivite gösterdiği belirlendi.

Anahtar Kelimeler

1, 2, 4 - Triazole, Vitamin, Serum, Aminometil Türevi, Karaciğer, Böbrek, Fare

Kaynakça

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