THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS

Yıl 2018, Cilt: 13 Sayı: 1, 1 - 6, 20.01.2018

Aysel Sarı , Alaaddin Çukurovalı

Öz

Thiosemicarbazones
(TSC) are a class of compounds very promising in the treatment of many
diseases, cancer in particular, and its development is still in progress. The purpose of
the present study was to evaluate the effect of 1-(1-phenil-1-methylcyclobutane-3-yl)-2-suksinimido
etanonthiosemicarbazone (FSTSC) on antioxidan vitamins (A,
E, C) in liver, kidney and serum of rabbits. Twenty male rabbits were randomly divided into two groups. The
first group was used as a control which injected
subcutaneously
of 250µl, 10% dimethylsulphoxide was given to the control group every otherday.
FSTSC compound (25mgkg^–1, dissolved in 250µl, 10%
dimethylsulphoxide) was administered to the other group of rabbits.This
administration was done for a period of 32days.The vitamin levels (A, E and C) were
determined by high performance liquid chromatography (HPLC). The liver tissue and
serum vitamin C levels were significantly decreased compared to control group
(P<0.05). Levels of vitamins A in kidney was significantly decreased
compared to control group (P<0.05). In addition to many pharmacological
properties of the TSC derivatives examined, it will contribute to the knowledge
of the literature.

Anahtar Kelimeler

Thiosemicarbazone, Antioxidants, Liver, Kidney, Serum, Rabbit, HPLC, HPLC

Kaynakça

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