An Overview of Pituitary Follicular-Stellate Cells

Öz

The pituitary gland is a small endocrine organ with an average weight of 0.5 grams, located on the bone structure called sella turcica at the base of the brain and surrounded by the diaphragmatic sella extension of the dura mater. Folliculo-stellate cells are one of the cells found in the pituitary gland. Unlike pituitary endocrine cells, these cells do not synthesize hormones. They have cytoplasmic extensions, similar to stellate cells found in the liver and pancreas. Light microscopic and electron microscopic studies have provided many data on these cells. However, although many morphological and functional features of these cells have been discovered in studies carried out to date, their basic functions are still not fully known. In this study, it is aimed to compile data on the general properties and functions of folliculo-stellate cells.

Anahtar Kelimeler

• Pituitary gland
• adenohypophysis
• folliculo-stellate cell

Hipofiz Follikülo-Stellat Hücrelerine Genel Bir Bakış

Öz

Hipofiz bezi, beyin tabanında sella tursika adı verilen kemik yapı üzerinde yer alan ve duramaterin diyafragma sella uzantısı ile çevrili olan ortalama 0.5 gram ağırlığında küçük bir endokrin organdır. Follikülo-stellat hücreler hipofiz bezinde yer alan hücrelerden biridir. Hipofizin endokrin hücrelerinin aksine bu hücrelerin hormon sentezleri yoktur. Karaciğer ve pankreasta bulunan stellat hücrelere benzer şekilde sitoplazmik uzantıları vardır. Işık mikroskobik ve elektron mikroskobik çalışmalar bu hücreler hakkında birçok veri sağlamıştır. Ancak günümüze kadar yapılan çalışmalarda bu hücrelerin birçok morfolojik ve fonksiyonel özelliği keşfedilmiş olsa da temel fonksiyonları halen tam olarak bilinememektedir. Bu çalışmada follikülo-stellat hücrelerin genel özellikleri ve fonksiyonları hakkındaki verilerin derlenmesi amaçlanmıştır.

Anahtar Kelimeler

• Hipofiz
• adenohipofiz
• follikülo-stellat hücre

Kaynakça

1. 1. Mancall EL, Brock DG (eds). "Cranial Fossae". Gray's Clinical Anatomy. Elsevier Health Sciences. 2011; 154.
2. 2. Pawlina W. Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 5th Edition 2011; 689-691.
3. 3. Rinehart JF, Farquhar MG. Electron microscopic studies of the anterior pituitary gland. J Histochem Cytochem. 1953; 1(2): 93-113.
4. 4. Bergland RM, Torack RM. An ultrastructural study of follicular cells in the human anterior pituitary. Am J Pathol. 1969; 57(2): 273-297.
5. 5. Vila-Porcile E. The network of the folliculo-stellate cells and the follicules of the adenohypophysis in the rat (pars distalis). Z Zellforsch Mikrosk Anat. 1972; 129(3): 328-369.6.
6. 6. Devnath S, Inoue K. An insight to pituitary folliculo-stellate cells. J Neuroendocrinol. 2008; 20(6): 687-691.
7. 7. Allaerts W, Vankelecom H. History and perspectives of pituitary folliculo-stellate cell research. European Journal of Endocrinology. 2005; 153(1): 1–12.
8. 8. Tsukada T, Fujiwara K, Horiguchi K, Azuma M, Ramadhani D, Tofrizal A, Batchuluun K, Maliza R, Syaidah R, Kikuchi M, Yashiro T. Folliculostellate Cells Are Required for Laminin Release from Gonadotrophs in Rat Anterior Pituitary. Acta Histochem Cytochem. 2014; 31: 47(5): 239–245.

9. 9. Yamashita M, Qian ZR, Sano T, Horvath E, Kovacs K. Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis. Pathol Int. 2005; 55(5): 244-247.
10. 10. Nakajima T, Yamaguchi H, Takahashi K. S100 protein in folliculostellate cells of the rat pituitary anterior lobe. Brain Res. 1980; 191(2): 523–531.
11. 11. Horvath E, Kovacs K. Folliculo-stellate cells of the human pituitary: a type of adult stem cell?. Ultrastructural Pathology. 2002; 26(4): 219–228.
12. 12. Herrmann H, Aebi U. Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular scaffolds. Annual Review of Biochemistry. 2004; 73: 749-789.
13. 13. Le Tissier PR, Hodson DJ, Lafont C, Fontanaud P, Schaeffer M, Mollard P. Anterior pituitary cell networks. Frontier Neuroendocrinol. 2012; 33(3): 252-266.
14. 14. Morand I, Fonlupt P, Guerrier A, Trouillas J, Calle A, Remy C, Rousset B, Munari-Silem Y. Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and folliculostellate cells. Endocrinology. 1996; 137(8): 3356–3367.
15. 15. Inoue K, Couch EF, Takano K, Ogawa S. The structure and function of folliculo-stellate cells in the anterior pituitary gland. Archives of Histology and Cytology. 1999; 62(3): 205-218.
16. 16. Allaerts W, Carmeliet P, Denef C. New perspectives in the function of folliculo‐stellate cells. Mol Cell Endocrinol 1990; 71(2): 73– 81.
17. 17. Brokken LJ, Leendertse M, Bakker O, Wiersinga WM, Prummel MF. Expression of adenohypophyseal-hormone receptors in a murine folliculo-stellate cell line. Horm Metab Res. 2004; 36(8): 538-541.
18. 18. Xia Y, Schneyer AL. The biology of activin: recent advances in structure, regulation and function. J Endocrinol. 2009; 202(1): 1-12.
19. 19. Tierney T, Christian HC, Morris JF, Solito E, Buckingham JC. Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release. J Neuroendocrinology. 2003; 15(12): 1134–1143.
20. 20. Pires M, Tortosa F. Update on pituitary folliculo-stellate cells. Int Arch Endocrinol Clin Res. 2016; 2: 006.
21. 21. Cristina C, Luque GM, Demarchi G, Felicitas LV, Zubeldia-Brenner L, Millan MIP, Perrone S, Ornstein AM, Lacau-Mengido IM, Berner SI, Becu-Villalobos D. Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models. Int J Endocrinol. 2014; 2014: 1-11.
22. 22. Vitale ML, Barry A. Biphasic Effect of Basic Fibroblast Growth Factor on Anterior Pituitary Folliculostellate TtT/GF Cell Coupling, and Connexin 43 Expression and Phosphorylation. J Neuroendocrinol. 2015; 27(10): 787-801. 23. Flaster H, Bernhagen J, Calandra T, Bucala R. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Molecular Endocrinology. 2007; 21(6): 1267–1280.
23. 24. Tierney T, Patel R, Stead CA, Leng L, Bucala R, Buckingham JC. Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release. Endocrinology. 2005; 146(1): 35-43.
24. 25. Albrecht J. Sonnewald U, Waagepetersen HS, Schousboe A. Glutamine in the central nervous system: function and dysfunction. Frontiers in Bioscience. 2007; 12: 332-343.
25. 26. Jones SE, Jomary C. Clusterin. The International Journal of Biochemistry & Cell Biology. 2002; 34(5): 427–431.
26. 27. Claudius L, Yoshimi Y, Yoichiro H, Gabriel M, Koichi M. Phagocytotic removal of apoptotic endocrine cells by folliculostellate cells and its functional implications in clusterin accumulation in pituitary colloids in helmeted guinea fowl (Numida meleagris). Acta Histochem 2006; 108(1): 69–80.