Olgu Sunumu
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Makrofaj Aktivasyon Sendromu Ve Difüz Alveolar Hemoraji ile Komplike Olan Erişkin Still Hastalığı Olgusu

Yıl 2023, , 105 - 110, 31.08.2023
https://doi.org/10.56941/odutip.1293362

Öz

Erişkin Still Hastalığı (ESH) yüksek ateş, deri döküntüsü, artrit, ferritin yüksekliği ve organ tutulumuyla karakterize etyolojisi tam olarak bilinmeyen, nadir görülen inflamatuar bir hastalıktır. ESH’de nadirde olsa, potansiyel olarak ölümcül bir komplikasyon olarak Makrofaj Aktivasyon Sendromu (MAS) görülebilir. Biz burada kronik artiküler form ESH tanısıyla takip edilirken genel durum bozukluğu, ferritin artışı ve sitopeni gelişmesi üzerine MAS tanısı alan ve kısa bir süre sonra da Diffüz alveoler hemoraji (DAH) gelişen bir olguyu sunduk. Kortikosteroid ve tosilizumab tedavisine dramatik cevap veren bu olgu sunumu ile ESH sonrası gelişen nadir komplikasyonlara dikkat çekmeyi amaçladık.

Proje Numarası

1

Kaynakça

  • 1. Gerfaud-Valentin M, Jamilloux Y, Iwaz J, Sève P. Adult-onset Still's disease. Autoimmunity reviews. 2014;13(7):708-22.
  • 2. Hot A, Toh M-L, Coppéré B, Perard L, Madoux MHG, Mausservey C, et al. Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features and long-term outcome: a case-control study of 8 patients. Medicine. 2010;89(1):37-46.
  • 3. Arlet J-B, Huong DLT, Marinho A, Amoura Z, Wechsler B, Papo T, et al. Reactive haemophagocytic syndrome in adult-onset Still’s disease: a report of six patients and a review of the literature. Annals of the Rheumatic Diseases. 2006;65(12):1596-601.
  • 4. Travis WD, Colby TV, Lombard C, Carpenter HA. A clinicopathologic study of 34 cases of diffuse pulmonary hemorrhage with lung biopsy confirmation. The American journal of surgical pathology. 1990;14(12):1112-25.
  • 5. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still's disease. The Journal of rheumatology. 1992;19(3):424-30.
  • 6. Gavand P-E, Serio I, Arnaud L, Costedoat-Chalumeau N, Carvelli J, Dossier A, et al. Clinical spectrum and therapeutic management of systemic lupus erythematosus-associated macrophage activation syndrome: a study of 103 episodes in 89 adult patients. Autoimmunity reviews. 2017;16(7):743-9.
  • 7. Sari I, Birlik M, Binicier O, Akar S, Yilmaz E, Onen F, et al. A case of adult-onset Still's disease complicated with diffuse alveolar hemorrhage. Journal of Korean medical science. 2009;24(1):155-7.
  • 8. Arndt PG, Fantuzzi G, Abraham E. Expression of interleukin-18 in the lung after endotoxemia or hemorrhage-induced acute lung injury. American journal of respiratory cell and molecular biology. 2000;22(6):708-13.
  • 9. Jennings CA, King Jr TE, Tuder R, Cherniack RM, Schwarz M. Diffuse alveolar hemorrhage with underlying isolated, pauciimmune pulmonary capillaritis. American journal of respiratory and critical care medicine. 1997;155(3):1101-9.
  • 10. Fujii T, Akizuki M, Kameda H, Matsumura M, Hirakata M, Yoshida T, et al. Methotrexate treatment in patients with adult onset Still’s disease—retrospective study of 13 Japanese cases. Annals of the rheumatic diseases. 1997;56(2):144-8.
  • 11. Franchini S, Dagna L, Salvo F, Aiello P, Baldissera E, Sabbadini MG. Efficacy of traditional and biologic agents in different clinical phenotypes of adult‐onset Still's disease. Arthritis & Rheumatism. 2010;62(8):2530-5.
  • 12. Kaneko Y, Kameda H, Ikeda K, Ishii T, Murakami K, Takamatsu H, et al. Tocilizumab in patients with adult-onset still’s disease refractory to glucocorticoid treatment: a randomised, double-blind, placebo-controlled phase III trial. Annals of the rheumatic diseases. 2018;77(12):1720-9.

A Case of Adult-onset Still’s Disease Complicated with Macrophage Activation Syndrome and Diffuse Alveolar Hemorrhage

Yıl 2023, , 105 - 110, 31.08.2023
https://doi.org/10.56941/odutip.1293362

Öz

Adult-onset Still’s Disease (AOSD) is a rare inflammatory disease of unknown etiology characterized by high fever, skin rash, arthritis, elevated ferritin and organ involvement. Macrophage Activation Syndrome (MAS) can be seen as a rare, potentially fatal complication in AOSD. Here, we presented a case who was diagnosed with MAS due to general condition disorder, increased ferritin and cytopenia while being followed up with the diagnosis of chronic articular form ESH, and then developed diffuse alveolar hemorrhage (DAH) after a short time. We aimed to draw attention to rare complications after AOSD with this case report that showed a dramatic response to corticosteroid and tocilizumab treatment.

Destekleyen Kurum

Funding: The authors received no financial support for the research and/or authorship of this article.

Proje Numarası

1

Teşekkür

We would like to thank Dr. Nurullah Akkoç for their valuable support and guidance.

Kaynakça

  • 1. Gerfaud-Valentin M, Jamilloux Y, Iwaz J, Sève P. Adult-onset Still's disease. Autoimmunity reviews. 2014;13(7):708-22.
  • 2. Hot A, Toh M-L, Coppéré B, Perard L, Madoux MHG, Mausservey C, et al. Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features and long-term outcome: a case-control study of 8 patients. Medicine. 2010;89(1):37-46.
  • 3. Arlet J-B, Huong DLT, Marinho A, Amoura Z, Wechsler B, Papo T, et al. Reactive haemophagocytic syndrome in adult-onset Still’s disease: a report of six patients and a review of the literature. Annals of the Rheumatic Diseases. 2006;65(12):1596-601.
  • 4. Travis WD, Colby TV, Lombard C, Carpenter HA. A clinicopathologic study of 34 cases of diffuse pulmonary hemorrhage with lung biopsy confirmation. The American journal of surgical pathology. 1990;14(12):1112-25.
  • 5. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult Still's disease. The Journal of rheumatology. 1992;19(3):424-30.
  • 6. Gavand P-E, Serio I, Arnaud L, Costedoat-Chalumeau N, Carvelli J, Dossier A, et al. Clinical spectrum and therapeutic management of systemic lupus erythematosus-associated macrophage activation syndrome: a study of 103 episodes in 89 adult patients. Autoimmunity reviews. 2017;16(7):743-9.
  • 7. Sari I, Birlik M, Binicier O, Akar S, Yilmaz E, Onen F, et al. A case of adult-onset Still's disease complicated with diffuse alveolar hemorrhage. Journal of Korean medical science. 2009;24(1):155-7.
  • 8. Arndt PG, Fantuzzi G, Abraham E. Expression of interleukin-18 in the lung after endotoxemia or hemorrhage-induced acute lung injury. American journal of respiratory cell and molecular biology. 2000;22(6):708-13.
  • 9. Jennings CA, King Jr TE, Tuder R, Cherniack RM, Schwarz M. Diffuse alveolar hemorrhage with underlying isolated, pauciimmune pulmonary capillaritis. American journal of respiratory and critical care medicine. 1997;155(3):1101-9.
  • 10. Fujii T, Akizuki M, Kameda H, Matsumura M, Hirakata M, Yoshida T, et al. Methotrexate treatment in patients with adult onset Still’s disease—retrospective study of 13 Japanese cases. Annals of the rheumatic diseases. 1997;56(2):144-8.
  • 11. Franchini S, Dagna L, Salvo F, Aiello P, Baldissera E, Sabbadini MG. Efficacy of traditional and biologic agents in different clinical phenotypes of adult‐onset Still's disease. Arthritis & Rheumatism. 2010;62(8):2530-5.
  • 12. Kaneko Y, Kameda H, Ikeda K, Ishii T, Murakami K, Takamatsu H, et al. Tocilizumab in patients with adult-onset still’s disease refractory to glucocorticoid treatment: a randomised, double-blind, placebo-controlled phase III trial. Annals of the rheumatic diseases. 2018;77(12):1720-9.
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Olgu sunumu
Yazarlar

Kezban Armagan 0000-0001-7380-6097

Özgül Soysal Gündüz 0000-0002-8149-9311

Proje Numarası 1
Yayımlanma Tarihi 31 Ağustos 2023
Yayımlandığı Sayı Yıl 2023

Kaynak Göster

Vancouver Armagan K, Soysal Gündüz Ö. A Case of Adult-onset Still’s Disease Complicated with Macrophage Activation Syndrome and Diffuse Alveolar Hemorrhage. ODU Tıp Derg. 2023;10(2):105-10.