Capecitabine-induced hand foot syndrome: a brief look at possible pathways that may be associated with inflammation

Öz

Hand foot syndrome is a toxic reaction related to certain chemotherapy agents. Capecitabine is a prodrug used in the treatment of many cancers, such as gastrointestinal, biliary tract and breast cancers. It is associated with hand and foot syndrome (HFS), which preferentially affects palms and soles. There is still no consensus on effective international standard therapeutic strategies for the treatment and prevention of HFS because the underlying physiological and pharmacological mechanisms leading to the development of HFS have not been adequately explained. HFS is rarely life-threatening, but it may deteriorate the patient’s quality of life. Quitting or a reduction in the dose of the causative drug mostly provide the amelioration of the symptoms. The aim of this review is to briefly evaluate the possible inflammatory mechanisms that may be associated with capecitabine- induced HFS.

Anahtar Kelimeler

• Capecitabine
• Hand foot syndrome
• Cyclooxygenase 2

Kapesitabine bağlı el ayak sendromu: enflamasyonla ilişkili olabilecek olası yolaklara kısa bir bakış

Öz

El ayak sendromu, belirli bazı kemoterapi ajanlarıyla ilişkili toksik bir reaksiyondur. Kapesitabin, gastrointestinal sistem, safra yolları ve meme kanserleri gibi birçok kanserin tedavisinde kullanılan bir ön ilaçtır. Tercihen avuç içi ve ayak tabanlarını etkileyen el ve ayak sendromu (HFS) ile ilişkilidir. HFS gelişimine yol açan altta yatan fizyolojik ve farmakolojik mekanizmalar yeterince açıklanamadığından, HFS'nin tedavisi ve önlenmesi için etkili uluslararası standart tedavi edici stratejiler üzerinde hala bir görüş birliği yoktur. HFS nadiren yaşamı tehdit eder, ancak hastanın yaşam kalitesini bozabilir. Sebep olan ilacın bırakılması veya dozunun azaltılması çoğunlukla semptomların düzelmesini sağlar. Bu derlemenin amacı, kapesitabin ile indüklenen HFS ile ilişkili olabilecek olası enflamatuvar mekanizmaları kısaca değerlendirmektir.

Anahtar Kelimeler

• Kapesitabin
• El ayak sendromu
• siklooksijenaz-2

Kaynakça

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