The Role of the Ozone in Management of Temporomandibular Joint Disorders

Öz

Temporomandibular disorder is a term that include a variety of clinical problems related with the temporomandibular joint and/ or masticatory muscles. In the treatment of temporomandibular disorders; conservative treatments such as physical therapy, pharmacological therapy, cognitive behavioral therapy, and intraoral appliances or surgical treatments can be performed. Recently in the treatment of temporomandibular disorders; alternative treatment methods such as low-level laser therapy, transcutaneous electrical nerve stimulation, ultrasound, and ozone therapy are also being used. Ozone is an unstable compound consisting of three oxygen atoms and has been used in medicine for many years because of its strong oxidant properties. Although ozone has been used in musculoskeletal diseases since the 1980s, its use in the treatment of temporomandibular joint disorders is relatively new. The purpose of this review is to evaluate the role of ozone in the treatment of temporomandibular joint disorders in the light of the literature.

Anahtar Kelimeler

• Ozone
• temporomandibular joint disorders
• internal derangement
• myofascial pain

Ozonun Temporomandibular Eklem Bozukluklarının Tedavisindeki Yeri

Öz

Temporomandibular bozukluk; temporomandibular eklem ve/veya çiğneme kasları ile ilişkili çeşitli klinik problemleri kapsayan bir terimdir. Temporomandibular bozuklukların tedavisinde; fizik tedavi, farmakolojik tedavi, bilişsel davranışçı terapi, ve intraoral apareyler gibi konservatif tedaviler veya cerrahi tedaviler uygulanabilir. Son zamanlarda temporomandibular bozuklukların tedavisinde; düşük seviyeli lazer tedavisi, transkutanöz elektriksel sinir stimülasyonu, ultrason ve ozon tedavisi gibi alternatif tedavi yöntemleri de uygulanmaktadır. Ozon, üç oksijen atomundan oluşan kararsız yapıdaki bir bileşiktir ve güçlü oksidan özelliği sayesinde tıpta uzun yıllardır kullanılmaktadır. Ozon, kas-iskelet sistemi hastalıklarında 1980’li yıllardan beri kullanılmakla birlikte, temporomandibular eklem bozukluklarının tedavisindeki kullanımı nispeten yenidir. Bu derlemenin amacı; ozonun temporomandibular eklem bozukluklarının tedavisindeki yerinin literatür ışığında değerlendirilmesidir.

Anahtar Kelimeler

• Ozon
• temporomandibular eklem bozuklukları
• internal düzensizlik
• miyofasiyal ağrı

Kaynakça

1. 1. Celakil T, Muric A, Gökcen Roehlig B, Evlioglu G. Management of pain in TMD patients: Bio-oxidative ozone therapy versus occlusal splints. Cranio 2019;37(2):85-93.
2. 2. Yamaner FE, Celakil T, Gökcen Roehlig B. Comparison of the efficiency of two alternative therapies for the management of temporomandibular disorders. Cranio 2020: 1-10.
3. 3. Özalp Ö, Yildirimyan N, Sindel A, Altay MA, Kişnişci RŞ. Evaluation of the short-term efficacy of transdermal ozone therapy in turkish patients with internal derangement of the temporomandibular joint. Pesqui Bras Odontopediatria Clín Integr 2019;19:e4442.
4. 4. Celakil T, Muric A, Gokcen Roehlig B, Evlioglu G, Keskin H. Effect of high-frequency bio-oxidative ozone therapy for masticatory muscle pain: a double-blind randomised clinical trial. J Oral Rehabil 2017;44(6):442-51.
5. 5. Ingawalé S, Goswami T. Temporomandibular joint: Disorders, treatments, and biomechanics. Ann Biomed Eng 2009;37(5):976-96.
6. 6. Daif ET. Role of intra-articular ozone gas injection in the management of internal derangement of the temporomandibular joint. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113(6):e10-4.
7. 7. Tortelli SAC, Saraiva L, Miyagaki DC. Effectiveness of acupuncture, ozonio therapy and low-intensity laser in the treatment of temporomandibular dysfunction of muscle origin: a randomized controlled trial. Rev Odontol UNESP 2019;48:e20190107.
8. 8. Doğan M, Ozdemir Doğan D, Düger C, Ozdemir Kol I, Akpınar A, Mutaf B, et al. Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Med Princ Pract 2014;23(6):507-10.

9. 9. Shabaan AA, Sabry D. Efficiency of temporomandibular joint arthrocentesis with ozonated water in management of anterior disc displacement without reduction: a randomized clinical trial. Egypt Dent J 2017;63(4):3133-42.
10. 10. Elsholkamy MA. A novel treatment for temporomandibular joint internal derangement: a randomized controlled clinical study. Egypt Dent J 2018;64(4):3165-72.
11. 11. Latini E, Curci ER, Massimiani A, Nusca SM, Santoboni F, Trischitta D, et al. Ultrasonography for oxygen-ozone therapy in musculoskeletal diseases. Med Gas Res 2019;9(1):18-23.
12. 12. Borges GÁ, Elias ST, da Silva SM, Magalhães PO, Macedo SB, Ribeiro AP, et al. In vitro evaluation of wound healing and antimicrobial potential of ozone therapy. J Craniomaxillofac Surg 2017;45(3):364-70.
13. 13. Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques JL. Ozone therapy in medicine and dentistry. J Contemp Dent Pract 2008;9(4):75-84.
14. 14. Baysan A, Lynch E. The use of ozone in dentistry and medicine. Prim Dent Care 2005;12(2):47-52.
15. 15. Kazancioglu HO, Ezirganli S, Aydin MS. Effects of laser and ozone therapies on bone healing in the calvarial defects. J Craniofac Surg 2013;24(6):2141-6.
16. 16. Hammuda, A, Hamed MS, Elsharrawy EA, Elsholkamy MA, Iskandar A. Use of ozone in temporomandibular joint arthrocentesis, clinical study. J Am Sci 2013;9(7):508-13.
17. 17. Yucesoy T, Kutuk N, Canpolat DG, Alkan A. Comparison of ozone and photo-biomodulation therapies on mental nerve injury in rats. J Oral Maxillofac Surg 2017;75(11):2323-32.
18. 18. Kazancioglu HO, Kurklu E, Ezirganli S. Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. Int J Oral Maxillofac Surg 2014;43(5):644-8.
19. 19. Dıraçoğlu D. Kas iskelet hastalıklarında ozon-oksijen tedavileri. Turk J Phys Med Rehab 2016;62(2):183-91.
20. 20. Seyam O, Smith NL, Reid I, Gandhi J, Jiang W, Khan SA. Clinical utility of ozone therapy for musculoskeletal disorders. Med Gas Res 2018;8(3):103-10.
21. 21. Bolgaev AB. Use of ozone in complex treatment of complicated fractures of the lower thoracic and lumbar sections of the spine. Sov Med 1989;(12):112-4.
22. 22. Riva Sanseverino E. Knee-joint disorders treated by oxygen-ozone therapy. Eur Med Phys 1989;25(3):163-70.
23. 23. Méndez-Pérez I, Cerro-Montesino A del, Cámbara-Peña R, Martínez-Godínez J, Menéndez-Cepero S. Ozonoterapia sistémica e intra-articular en la artritis de la articulación temporomandibular por artritis reumatoide. Rev CENIC Cien Biol 2010;41(3):169-72.
24. 24. Arafat SW, Chehata IM. Clinical and biochemical assessment of different injection materials following arthrocentesis for the treatment of internal derangement of the temporomandibular joint: A comparative study. Tanta Dent J 2016;13(2):102-8.
25. 25. Öz S, Gökçen-Röhlig B, Saruhanoglu, A, Tuncer EB. Management of myofascial pain: Low-level laser therapy versus occlusal splints. J Craniofac Surg 2010;21(6):1722-8.
26. 26. Velly AM, Gornitsky M, Philippe P. Contributing factors to chronic myofascial pain: A case-control study. Pain 2003;104(3):491-9.
27. 27. Pantoja LLQ, de Toledo IP, Pupo YM, Porporatti AL, De Luca Canto G, Zwir LF, et al. Prevalence of degenerative joint disease of the temporomandibular joint: a systematic review. Clin Oral Investig 2019;23(5):2475-88.
28. 28. Cömert Kılınç S , Güngörmüş M . Temporomandibular eklem osteoartritli hastalarda artrosentezi takiben yapılan trombositten zengin plazma, hyaluronik asit ve kortikosteroid enjeksiyonlarının temporomandibular eklem palpasyonunda oluşan ağrıya etkilerinin karşılaştırılması. Ata Diş Hek Fak Derg 2016;26(3):407-12.
29. 29. Tanaka E, Detamore MS, Mercuri LG. Degenerative disorders of the Temporomandibular joint: etiology, diagnosis, and treatment. J Dent Res 2008;87(4):296-307.
30. 30. Mishra SK, Pramanik R, Das P, Das PP, Palit AK, Roy J, et al. Role of intra-articular ozone in osteo-arthritis of knee for functional and symptomatic improvement. IJPMR 2011;22:65-9.
31. 31. Hashemi M, Jalili P, Mennati S, Koosha A, Rohanifar R, Madadi F, et al. The effects of prolotherapy with hypertonic dextrose versus prolozone (intraarticular ozone) in patients with knee osteoarthritis. Anesth Pain Med 2015;5(5):e27585.
32. 32. Chansoria M, Upadhyay S, Panwar S, Shivhare P, Vyas N. Comparative efficacy of intraarticular injection of combination of ozone and steroid and ozone alone in patients with primary knee osteoarthritis: a prospective and randomized clinical analysis. J Recent Adv Pain 2016;2(1):11-4.
33. 33. Hashemi M, Nabi BN, Saberi A, Sedighinejad A, Haghighi M, Farzi F, et al. The comparison between two methods for the relief of knee osteoarthritis pain: radiofrequency and intra-periarticular ozone injection: a clinical trial study. Int J Med Res Health Sci 2016;5(7S):539-46.
34. 34. Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc 2017;25(2):485-92.
35. 35. Invernizzi M, Stagno D, Carda S, Grana E, Picelli A, Smania N, et al. Safety of intra-articular oxygen-ozone therapy compared to intra-articular sodium hyaluronate in knee osteoarthritis: a randomized single blind pilot study. Int J Phys Med Rehabil 2017;5(1):385.
36. 36. Hashemi M, Hoseini Khameneh SM, Mohajerani SA, Dadkhah P. Effect of intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis. J Cell Mol Anesth 2017;2(2):37-42.
37. 37. Lopes de Jesus CC, Dos Santos FC, de Jesus LMOB, Monteiro I, Sant’Ana MSSC, Trevisani VFM. Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: A randomized, double-blinded, placebo-controlled study. PLoS One 2017;12(7):e0179185.
38. 38. Feng X, Beiping L. Therapeutic efficacy of ozone injection into the knee for the osteoarthritis patient along with oral celecoxib and glucosamine. J Clin Diagn Res 2017;11(9):UC01-3.
39. 39. Babaei-Ghazani A, Najarzadeh S, Mansoori K, Forogh B, Madani SP, Ebadi S, et al. The effects of ultrasound-guided corticosteroid injection compared to oxygen–ozone (O2–O3) injection in patients with knee osteoarthritis: a randomized controlled trial. Clin Rheumatol 2018;37(9):2517-27.
40. 40. Raeissadat SA, Rayegani SM, Forogh B, Hassan Abadi P, Moridnia M, Rahimi Dehgolan S. Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial. J Pain Res 2018;11:111-7.
41. 41. Fernández-Cuadros ME, Pérez-Moro OS, Albaladejo-Florín MJ, Entrambasaguas-Estepa B, Alava-Rabasa S. Mid-term effectiveness of ozone (O2-O3) compared to platelet-rich plasma (PRP) in the management of knee osteoarthritis: A randomized parallel controlled trial. Middle East J Rehabil Health Stud 2019;6(2):e74140.
42. 42. Dernek B, Kesiktas FN. Efficacy of combined ozone and platelet-rich-plasma treatment versus platelet-rich-plasma treatment alone in early stage knee osteoarthritis. J Back Musculoskelet Rehabil 2019;32(2):305-11.