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Nutritional Strategies in Hashimoto's Thyroiditis: Dietary Patterns and Supplementation

Yıl 2025, Cilt: 3 Sayı: 1, 12 - 19, 01.03.2025

Öz

Hashimoto's thyroiditis (HT) is one of the most common autoimmune diseases of the thyroid gland and is common in women. The dietary habits of patients generally tend towards Western-type diets. Patients are generally malnourished regarding energy, omega-3 fatty acids, dietary fiber, vitamins, and minerals. In addition, obesity, diabetes, dyslipidemia, anemia, and gastrointestinal symptoms are frequently observed in these patients. The occurrence of nutritional deficiencies in HT may exacerbate the disease. Therefore, appropriate nutritional therapy can help regulate the immune system, reduce inflammation, and improve overall health. In these patients, nutritional therapy should be planned in line with their symptoms and other diseases, considering their eating habits, physical and social environment, and psychological status. Energy balance should be adjusted according to individual needs, especially foods containing healthy fats and high fiber, which should be preferred, and consumption of processed foods should be avoided. Micronutrient deficiencies should be eliminated; however, caution should be exercised about excessive use of dietary supplements in patients with HT, and dietary supplements should not be recommended if the patient does not have nutrient deficiencies or if adequate intake of nutrients can be achieved with nutritional therapy. Although there is no conclusive evidence in the literature that gluten- or lactose-free diets benefit these patients, dietitians may evaluate these diets in appropriate patients.

Kaynakça

  • 1. Ralli M, Angeletti D, Fiore M, et al. Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmun Rev. 2020;19(10):102649.
  • 2. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13(4-5):391-397.
  • 3. Ihnatowicz P, Drywień M, Wątor P, Wojsiat J. The importance of nutritional factors and dietary management of Hashimoto's thyroiditis. Ann Agric Environ Med. 2020;27(2):184-193.
  • 4. Bellastella G, Scappaticcio L, Caiazzo F, et al. Mediterranean diet and thyroid: an ınteresting alliance. Nutrients. 2022;14(19):4130.
  • 5. Matana A, Torlak V, Brdar D, et al. Dietary factors associated with plasma thyroid peroxidase and thyroglobulin antibodies. Nutrients. 2017;9(11):1186.
  • 6. Kaličanin D, Brčić L, Ljubetić K, et al. Differences in food consumption between patients with Hashimoto's thyroiditis and healthy individuals. Sci Rep. 2020;10(1):10670.
  • 7. Guo X, Han, J, Bi W, Nir C. Investigation and analysis of daily diet and living habits of Hashimoto's thyroiditis patients. Chinese Journal of Endemiology, 2023;647-651.
  • 8. Mikulska AA, Karaźniewicz-Łada M, Filipowicz D, Ruchała M, Główka FK. Metabolic characteristics of hashimoto's thyroiditis patients and the role of microelements and diet in the disease management-an overview. Int J Mol Sci. 2022;23(12):6580. Published 2022 Jun 13. doi:10.3390/ijms23126580
  • 9. Virili C, Fallahi P, Antonelli A, Benvenga S, Centanni M. Gut microbiota and Hashimoto's thyroiditis. Rev Endocr Metab Disord. 2018;19(4):293-300. doi:10.1007/s11154-018-9467-y
  • 10. Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA. The impact of obesity on thyroid autoimmunity and dysfunction: a systematic review and meta-analysis. Front Immunol. 2019;10:2349.
  • 11. Mohammed Hussein SM, AbdElmageed RM. The relationship between type 2 diabetes mellitus and related thyroid diseases. Cureus. 2021;13(12):e20697.
  • 12.Ruggeri RM, Giovinazzo S, Barbalace MC, et al. Influence of dietary habits on oxidative stress markers in Hashimoto's thyroiditis. Thyroid: official journal of the American Thyroid Association. 2021;31(1):96-105.
  • 13.Giannakou M, Saltiki K, Mantzou E, et al. The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis. Endocr Connect. 2018;7(9):990-997.
  • 14.Marabotto E, Ferone D, Sheijani AD, et al. Prevalence of lactose ıntolerance in patients with hashimoto thyroiditis and ımpact on lt4 replacement dose. Nutrients. 2022;14(15):3017.
  • 15.Szczuko M, Syrenicz A, Szymkowiak K, et al. Doubtful justification of the gluten-free diet in the course of hashimoto's disease. Nutrients. 2022;14(9):1727.
  • 16.Pawlak W, Dudkiewicz M, Pawłocik W, Wojtala L, et al. (2023). Is there a diet for Hashimoto Thyroiditis?-review of literature. Progress in Health Sciences, 2023;13(1): 100-106.
  • 17.Ferrari SM, Patrizio A, Mazzi V, et al. Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose. Front Endocrinol (Lausanne). 2024;15:1386510.
  • 18.Larsen D, Singh S, Brito M. Thyroid, diet, and alternative approaches. J Clin Endocrinol Metab. 2022;107(11):2973-2981.
  • 19.Osowiecka K, Myszkowska-Ryciak J. The influence of nutritional ıntervention in the treatment of Hashimoto's thyroiditis-a systematic review. Nutrients. 2023;15(4):1041.
  • 20.Danailova Y, Velikova T, Nikolaev G, et al. Nutritional management of thyroiditis of Hashimoto. Int J Mol Sci. 2022;23(9):5144.
  • 21.Piticchio T, Frasca F, Malandrino P, et al. Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis. Front Endocrinol (Lausanne). 2023;14:1200372.
  • 22.Pobłocki J, Pańka T, Szczuko M, Telesiński A, Syrenicz A. Whether a gluten-free diet should be recommended in chronic autoimmune thyroiditis or not?-A 12-Month Follow-Up. J Clin Med. 2021;10(15):3240.
  • 23.Ülker MT, Çolak GA, Baş M, Erdem MG. Evaluation of the effect of gluten-free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditis. Food Sci Nutr. 2023;12(2):1180-1188.
  • 24.Krzysiek U, Podgórska K, Puła A, et al. Does a gluten-free diet affect the course of Hashimoto's disease?-the review of the literature. Journal of Education, Health and Sport, 2023;13(1):173-177.
  • 25.Malandrini S, Trimboli P, Guzzaloni G, Virili C, Lucchini B. What about TSH and anti-thyroid antibodies in patients with autoimmune thyroiditis and celiac disease using a gluten-free diet? a systematic review. Nutrients. 2022;14(8):1681.
  • 26.Asik M, Gunes F, Binnetoglu E, et al. Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance. Endocrine. 2014;46(2):279-284.
  • 27.Chen S, Peng Y, Zhang H, Zou Y. Relationship between thyroid function and dietary inflammatory index in Hashimoto thyroiditis patients. Medicine (Baltimore). 2023;102(46):e35951.
  • 28.Dahiya V, Vasudeva N, Sharma S, Kumar A. Role of Dietary supplements in thyroid diseases. Endocr Metab Immune Disord Drug Targets. 2022;22(10):985-996.
  • 29.Kubiak K, Szmidt MK, Kaluza J, Zylka A, Sicinska E. Do Dietary supplements affect ınflammation, oxidative stress, and antioxidant status in adults with hypothyroidism or hashimoto's disease?- A systematic review of controlled trials. Antioxidants (Basel). 2023;12(10):1798.
  • 30.Wu Q, Wang Y, Chen P, et al. Increased incidence of Hashimoto thyroiditis in selenium deficiency: A prospective 6-year cohort study. J Clin Endocrinol Metab. 2022;107(9):e3603-e3611.
  • 31.Zheng G, Cai Y, Guo Y, et al. The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National health and nutrition examination survey (NHANES), 2007-2012. J Endocrinol Invest. 2023;46(7):1385-1395.
  • 32.Huwiler VV, Maissen-Abgottspon S, Stanga Z, et al. Selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis of randomized clinical trials. Thyroid. 2024;34(3):295-313. 33.Rayman MP. Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. Proc Nutr Soc. 2019;78(1):34-44.
  • 34.Starchl C, Scherkl M, Amrein K. Celiac disease and the thyroid: Highlighting the roles of vitamin D and iron. Nutrients. 2021;13(6):1755
  • 35.Cvek M, Kaličanin D, Barić A, et al. Vitamin D and Hashimoto's thyroiditis: observations from CROHT Biobank. Nutrients. 2021;13(8):2793.
  • 36.Zhang J, Chen Y, Li H, Li H. Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis. J Int Med Res. 2021;49(12):3000605211060675.
  • 37.Jiang H, Chen X, Qian X, Shao S. Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto's thyroiditis-A meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2022;47(6):767-775.
  • 38.Ouyang Q, Xu Y, Ban Y, et al. Probiotics and prebiotics in subclinical hypothyroidism of pregnancy with small ıntestinal bacterial overgrowth. Probiotics Antimicrob Proteins. 2024;16(2):579-588.
  • 39.Hao Y, Xu Y, Ban Y, et al. Efficacy evaluation of probiotics combined with prebiotics in patients with clinical hypothyroidism complicated with small intestinal bacterial overgrowth during the second trimester of pregnancy. Front Cell Infect Microbiol. 2022;12:983027.
  • 40.Shu Q, Kang C, Li J, et al. Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. PLoS One. 2024;19(1):e0296733.
  • 41.Zawadzka K, Kałuzińska K, Świerz MJ, et al. Are probiotics, prebiotics, and synbiotics beneficial in primary thyroid diseases? A systematic review with meta-analysis. Ann Agric Environ Med. 2023;30(2):217-223.

Hashimoto Tiroiditinde Beslenme Stratejileri: Diyet Modelleri ve Takviye Uygulamaları

Yıl 2025, Cilt: 3 Sayı: 1, 12 - 19, 01.03.2025

Öz

Hashimoto tiroiditi (HT) tiroid bezinin en sık görülen otoimmün hastalıklarından biridir ve kadınlarda yaygındır. Hastaların beslenme alışkanlıkları genellikle Batı tipi diyetlere eğilim göstermektedir. Hastalar genellikle enerji, omega-3 yağ asitleri, diyet lifi, vitaminler ve mineraller açısından yetersiz beslenmektedir. Ayrıca bu hastalarda obezite, diyabet, dislipidemi, anemi ve gastrointestinal semptomlar sıklıkla görülmektedir. HT’de beslenme yetersizliklerinin ortaya çıkması hastalığı şiddetlendirebilmektedir. Bu nedenle uygun bir beslenme tedavisi, bağışıklık sisteminin düzenlenmesine, inflamasyonun azaltılmasına ve genel sağlığın iyileştirilmesine yardımcı olabilir. Bu hastalarda yeme alışkanlıkları, fiziki ve sosyal çevresi ile psikolojik durumu dikkate alınarak, semptomları ve diğer hastalıkları doğrultusunda beslenme tedavisi planlanmalıdır. Enerji dengesi bireysel ihtiyaçlara göre ayarlanmalı, özellikle sağlıklı yağlar ve yüksek lif içeren besinler tercih edilmeli, işlenmiş besinlerin tüketiminden uzak durulmalıdır. Mikro besin ögesi eksiklikleri giderilmelidir ancak HT’li hastalarda diyet takviyelerinin aşırı kullanımı konusunda dikkatli olunmalı, hastada besin ögesi yetersizlikleri yoksa veya beslenme tedavisiyle besin ögelerinin yeterli alımı sağlanabiliyorsa diyet takviyeleri önerilmemelidir. Glutensiz veya laktozsuz diyetlerin bu hastalarda yarar sağladığına yönelik literatürde henüz kesin kanıtlar olmamakla birlikte diyetisyenler uygun hastalarda bu diyetleri değerlendirebilir.

Kaynakça

  • 1. Ralli M, Angeletti D, Fiore M, et al. Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmun Rev. 2020;19(10):102649.
  • 2. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014;13(4-5):391-397.
  • 3. Ihnatowicz P, Drywień M, Wątor P, Wojsiat J. The importance of nutritional factors and dietary management of Hashimoto's thyroiditis. Ann Agric Environ Med. 2020;27(2):184-193.
  • 4. Bellastella G, Scappaticcio L, Caiazzo F, et al. Mediterranean diet and thyroid: an ınteresting alliance. Nutrients. 2022;14(19):4130.
  • 5. Matana A, Torlak V, Brdar D, et al. Dietary factors associated with plasma thyroid peroxidase and thyroglobulin antibodies. Nutrients. 2017;9(11):1186.
  • 6. Kaličanin D, Brčić L, Ljubetić K, et al. Differences in food consumption between patients with Hashimoto's thyroiditis and healthy individuals. Sci Rep. 2020;10(1):10670.
  • 7. Guo X, Han, J, Bi W, Nir C. Investigation and analysis of daily diet and living habits of Hashimoto's thyroiditis patients. Chinese Journal of Endemiology, 2023;647-651.
  • 8. Mikulska AA, Karaźniewicz-Łada M, Filipowicz D, Ruchała M, Główka FK. Metabolic characteristics of hashimoto's thyroiditis patients and the role of microelements and diet in the disease management-an overview. Int J Mol Sci. 2022;23(12):6580. Published 2022 Jun 13. doi:10.3390/ijms23126580
  • 9. Virili C, Fallahi P, Antonelli A, Benvenga S, Centanni M. Gut microbiota and Hashimoto's thyroiditis. Rev Endocr Metab Disord. 2018;19(4):293-300. doi:10.1007/s11154-018-9467-y
  • 10. Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA. The impact of obesity on thyroid autoimmunity and dysfunction: a systematic review and meta-analysis. Front Immunol. 2019;10:2349.
  • 11. Mohammed Hussein SM, AbdElmageed RM. The relationship between type 2 diabetes mellitus and related thyroid diseases. Cureus. 2021;13(12):e20697.
  • 12.Ruggeri RM, Giovinazzo S, Barbalace MC, et al. Influence of dietary habits on oxidative stress markers in Hashimoto's thyroiditis. Thyroid: official journal of the American Thyroid Association. 2021;31(1):96-105.
  • 13.Giannakou M, Saltiki K, Mantzou E, et al. The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis. Endocr Connect. 2018;7(9):990-997.
  • 14.Marabotto E, Ferone D, Sheijani AD, et al. Prevalence of lactose ıntolerance in patients with hashimoto thyroiditis and ımpact on lt4 replacement dose. Nutrients. 2022;14(15):3017.
  • 15.Szczuko M, Syrenicz A, Szymkowiak K, et al. Doubtful justification of the gluten-free diet in the course of hashimoto's disease. Nutrients. 2022;14(9):1727.
  • 16.Pawlak W, Dudkiewicz M, Pawłocik W, Wojtala L, et al. (2023). Is there a diet for Hashimoto Thyroiditis?-review of literature. Progress in Health Sciences, 2023;13(1): 100-106.
  • 17.Ferrari SM, Patrizio A, Mazzi V, et al. Lactose intolerance and levothyroxine malabsorption: a review of the literature and report of a series of patients treated with liquid L-T4 without lactose. Front Endocrinol (Lausanne). 2024;15:1386510.
  • 18.Larsen D, Singh S, Brito M. Thyroid, diet, and alternative approaches. J Clin Endocrinol Metab. 2022;107(11):2973-2981.
  • 19.Osowiecka K, Myszkowska-Ryciak J. The influence of nutritional ıntervention in the treatment of Hashimoto's thyroiditis-a systematic review. Nutrients. 2023;15(4):1041.
  • 20.Danailova Y, Velikova T, Nikolaev G, et al. Nutritional management of thyroiditis of Hashimoto. Int J Mol Sci. 2022;23(9):5144.
  • 21.Piticchio T, Frasca F, Malandrino P, et al. Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis. Front Endocrinol (Lausanne). 2023;14:1200372.
  • 22.Pobłocki J, Pańka T, Szczuko M, Telesiński A, Syrenicz A. Whether a gluten-free diet should be recommended in chronic autoimmune thyroiditis or not?-A 12-Month Follow-Up. J Clin Med. 2021;10(15):3240.
  • 23.Ülker MT, Çolak GA, Baş M, Erdem MG. Evaluation of the effect of gluten-free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditis. Food Sci Nutr. 2023;12(2):1180-1188.
  • 24.Krzysiek U, Podgórska K, Puła A, et al. Does a gluten-free diet affect the course of Hashimoto's disease?-the review of the literature. Journal of Education, Health and Sport, 2023;13(1):173-177.
  • 25.Malandrini S, Trimboli P, Guzzaloni G, Virili C, Lucchini B. What about TSH and anti-thyroid antibodies in patients with autoimmune thyroiditis and celiac disease using a gluten-free diet? a systematic review. Nutrients. 2022;14(8):1681.
  • 26.Asik M, Gunes F, Binnetoglu E, et al. Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance. Endocrine. 2014;46(2):279-284.
  • 27.Chen S, Peng Y, Zhang H, Zou Y. Relationship between thyroid function and dietary inflammatory index in Hashimoto thyroiditis patients. Medicine (Baltimore). 2023;102(46):e35951.
  • 28.Dahiya V, Vasudeva N, Sharma S, Kumar A. Role of Dietary supplements in thyroid diseases. Endocr Metab Immune Disord Drug Targets. 2022;22(10):985-996.
  • 29.Kubiak K, Szmidt MK, Kaluza J, Zylka A, Sicinska E. Do Dietary supplements affect ınflammation, oxidative stress, and antioxidant status in adults with hypothyroidism or hashimoto's disease?- A systematic review of controlled trials. Antioxidants (Basel). 2023;12(10):1798.
  • 30.Wu Q, Wang Y, Chen P, et al. Increased incidence of Hashimoto thyroiditis in selenium deficiency: A prospective 6-year cohort study. J Clin Endocrinol Metab. 2022;107(9):e3603-e3611.
  • 31.Zheng G, Cai Y, Guo Y, et al. The association between dietary selenium intake and Hashimoto's thyroiditis among US adults: National health and nutrition examination survey (NHANES), 2007-2012. J Endocrinol Invest. 2023;46(7):1385-1395.
  • 32.Huwiler VV, Maissen-Abgottspon S, Stanga Z, et al. Selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis of randomized clinical trials. Thyroid. 2024;34(3):295-313. 33.Rayman MP. Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. Proc Nutr Soc. 2019;78(1):34-44.
  • 34.Starchl C, Scherkl M, Amrein K. Celiac disease and the thyroid: Highlighting the roles of vitamin D and iron. Nutrients. 2021;13(6):1755
  • 35.Cvek M, Kaličanin D, Barić A, et al. Vitamin D and Hashimoto's thyroiditis: observations from CROHT Biobank. Nutrients. 2021;13(8):2793.
  • 36.Zhang J, Chen Y, Li H, Li H. Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis. J Int Med Res. 2021;49(12):3000605211060675.
  • 37.Jiang H, Chen X, Qian X, Shao S. Effects of vitamin D treatment on thyroid function and autoimmunity markers in patients with Hashimoto's thyroiditis-A meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2022;47(6):767-775.
  • 38.Ouyang Q, Xu Y, Ban Y, et al. Probiotics and prebiotics in subclinical hypothyroidism of pregnancy with small ıntestinal bacterial overgrowth. Probiotics Antimicrob Proteins. 2024;16(2):579-588.
  • 39.Hao Y, Xu Y, Ban Y, et al. Efficacy evaluation of probiotics combined with prebiotics in patients with clinical hypothyroidism complicated with small intestinal bacterial overgrowth during the second trimester of pregnancy. Front Cell Infect Microbiol. 2022;12:983027.
  • 40.Shu Q, Kang C, Li J, et al. Effect of probiotics or prebiotics on thyroid function: A meta-analysis of eight randomized controlled trials. PLoS One. 2024;19(1):e0296733.
  • 41.Zawadzka K, Kałuzińska K, Świerz MJ, et al. Are probiotics, prebiotics, and synbiotics beneficial in primary thyroid diseases? A systematic review with meta-analysis. Ann Agric Environ Med. 2023;30(2):217-223.
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Beslenme
Bölüm Derlemeler
Yazarlar

Kevser Karlı 0000-0001-8679-5542

Erken Görünüm Tarihi 26 Şubat 2025
Yayımlanma Tarihi 1 Mart 2025
Gönderilme Tarihi 30 Ağustos 2024
Kabul Tarihi 5 Şubat 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 3 Sayı: 1

Kaynak Göster

Vancouver Karlı K. Hashimoto Tiroiditinde Beslenme Stratejileri: Diyet Modelleri ve Takviye Uygulamaları. J One Health Res. 2025;3(1):12-9.