Atrial Conduction Time in Patients with Pseudoexfoliation Syndrome

Yıl 2019, Cilt: 41 Sayı: 1, 31 - 38, 01.01.2019

Taner Ulus Kamal Isgandarov Sayyed Hamed Moghanchızadeh Merve Bozkurt Fezan Mutlu Nilgün Yıldırım

https://doi.org/10.20515/otd.412143

Cited By: 1

Öz

Pseudoexfoliation syndrome (PEX) is a systemic disorder characterized by
the accumulation of an abnormal fibrillar material in various ocular and
extraocular tissues. Significant associations between PEX and cardiovascular,
and cerebrovascular diseases were found. There is some evidence suggesting an
increased risk of cardiac arrhythmias including atrial fibrillation (AF) in
patients with PEX. Impaired atrial electromechanical function plays a
significant role in the development of AF. This study aims to evaluate atrial
electromechanical delay (EMD) times in patients with PEX. Thirty-four PEX patients and 29 age-matched and sex-matched
healthy controls who had no PEX material were included. Fasting blood samples
were taken, transthoracic echocardiography and tissue Doppler imaging were
performed to determine atrial EMD times.
The S-wave velocity at the septal annulus, the S-wave velocity at the
lateral annulus, and the isovolumetric contraction velocity at the lateral
annulus were lower in patients with PEX than in controls (p=0.010, 0.025 and
0.014, respectively). Tissue Doppler imaging measurements showed that the atrial
electromechanical coupling time (PA) lateral, PA septal, and PA tricuspid were
higher in patients with PEX than in controls (p<0.001, 0.010 and 0.046,
respectively). Interatrial EMD [39.00 ms (28.00-44.00) vs 28.00 ms
(23.50-33.00), p=0.001] and intra-left atrial EMD [17.00 ms (15.00-23.25) vs 11.00
ms (10.00-17.50), p=0.003] were higher in patients with PEX.  Pseudoexfoliation
syndrome is associated with prolonged atrial EMD times. In addition, myocardial
systolic velocities are lower in patients with PEX.

Anahtar Kelimeler

Pseudoexfoliation syndrome, atrial fibrillation, atrial electromechanical delay

Psödoeksfoliasyon Sendromlu Hastalarda Atriyal İleti Zamanı

Öz

Pseudoeksfoliasyon
sendromu (PES) göz ve
göz dışı pek çok dokuda anormal hücre dışı fibriler mataryelin birikimi ile
karakterize sistemik bir hastalıktır. Pseudoeksfoliasyon sendromu ile kardiyovasküler ve serebrovasküler
hastalıklar arasında ciddi ilişkiler bulunmuştur. Atriyal fibrilasyonun  (AF) da dahil olduğu kardiyak aritmi riskinin
PES hastalarında arttığına dair bazı deliller mevcuttur. Bozulmuş atriyal elektromekanik
fonksiyon AF gelişiminde önemli bir rol oynar. Bu çalışma PES hastalarında atriyal
elektromekanik gecikme (EMG) sürelerinin değerlendirilmesini amaçlamaktadır. Otuz
dört PES hastası ve PES materyeli olmayan 29 yaş ve cinsiyet uyumlu sağlıklı
kontrol çalışmaya alındı. Açlık kan örnekleri alındı, transtorasik
ekokardiyografi ve atriyal EMG sürelerini belirlemek için doku Doppler inceleme
yapıldı. Septal anulusta
S dalga hızı, lateral anulusta S dalga hızı, lateral anulusta izovolümetrik
kasılma hızı PES olan grupta kontrol grubuna göre daha düşüktü (sırasıyla
p=0.010, 0.025 ve 0.014).
Doppler ekokardiyografi ölçümleri atriyal elektromekanik bağlama süresi (PA)
lateral, septal ve trikuspit’in PES hastalarında kontrollerden daha fazla
olduğunu gösterdi (sırasıyla p<0.001, 0.010 ve 0.046). İnteratriyal EMG
[39.00 ms (28.00-44.00) vs 28.00 ms (23.50-33.00), p=0.001] ve intra-sol
atriyal EMG [17.00 ms (15.00-23.25) vs 11.00 ms (10.00-17.50), p=0.003] PES
hastalarında daha fazlaydı.Pseudoeksfoliasyon sendromu uzamış atriyal EMG
süreleri ile ilişkilidir. Ayrıca miyokardiyal sistolik hızlar PES hastalarında
daha düşüktür. 

Anahtar Kelimeler

Pseudoeksfoliasyon sendromu, atriyal fibrilasyon, atriyal elektromekanik gecikme

Kaynakça

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