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Is Diabetesmellitus A Risk Factor for Oral Cancers?

Yıl 2020, Cilt 42, Sayı 5, 249 - 253, 28.09.2020
https://doi.org/10.20515/otd.771272

Öz

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insülin action, or both. In DM, which can be divided into two main groups, type 1 and type 2, microvascular and macrovascular complications occur a result of prolonged hyperglycemia.DM can lead to decreased salivary flow, periodontitis, and oral mucosal changes such as oral lichen planus, leukoplakia by causing many immunological and metabolic changes in the oral mucosa. Oral cancers are carcinomas that are found in middle age and over, frequently in males with high morbidity and mortality rates. Factors such as smoking and alcohol abuse play important role in the etiology. In the reported studies, it has been determined that type 2 DM is a risk factor for several cancers such as breast, endometrium, and pancreas, and the incidence of oral precancerous lesions increases with type 2 DM. Also, DM can lay the groundwork formation of oral cancers and to cause the deterioration of cancer prognosis. It has been thought that the etiological factors of DM such as hyperinsulinemia and obesity play a role in the emergence of this condition by various mechanisms and the drugs used in the management of DM effect on cancer. Although DM has been shown as a risk factor for oral cancers, the relationship between DM and oral cancer has not been fully clarified. In this review, the relationship between DM and oral cancers and possible pathobiological mechanisms in this relationship are discussed in the light of reported articles.

Kaynakça

  • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37(Supplement 1):S81-S90.
  • Cicmil S, Mladenović I, Krunić J, et al. Oral alterations in diabetes mellitus. Balk J Dent Med. 2018;22(1):7-14.
  • Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral oncol. 2009;45(4-5):309-16.
  • Deschler DG, Richmon JD, Khariwala SS, et al. The “new” head and neck cancer patient—young, nonsmoker, nondrinker, and HPV positive: evaluation. Otolaryngology--Head and Neck Surg. 2014;151(3):375-80.
  • Majchrzak E, Szybiak B, Wegner A, et al. Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature. Radiol oncol.2014;48(1):1-10.
  • Genden EM, Ferlito A, Silver CE, et al. Contemporary management of cancer of the oral cavity. Eur Arch Otorhinolaryngol.2010;267(7):1001-17.
  • Wong T, Wiesenfeld D. Oral cancer. AustDent J.2018;63:S91-S9.
  • Skamagas M, Breen T, LeRoith D. Update on diabetes mellitus: prevention, treatment, and association with oral diseases. Oral diseases. 2008;14(2):105-14.
  • Verhulst MJ, Loos BG, Gerdes VE, et al. Evaluating all potential oral complications of diabetes mellitus. Front Endocrinol.2019;10.
  • Negrato CA, Tarzia O. Buccal alterations in diabetes mellitus. Diabetol Metab Syndr. 2010;2(1):3.
  • Giovannucci E, Harlan DM, Archer MC, et al. Diabetes and cancer: a consensus report. CA: a cancer journal for clinicians 2010;60(4):207-21.
  • Lipscombe LL, Goodwin PJ, Zinman B, et al. The impact of diabetes on survival following breast cancer. Breast Cancer Res Treat.2008;109(2):389-95.
  • Dikshit RP, Ramadas K, Hashibe M, et al. Association between diabetes mellitus and pre‐malignant oral diseases: A cross sectional study in Kerala, India. Int J Cancer. 2006;118(2):453-7.
  • Dietrich T, Reichart PA, Scheifele C. Clinical risk factors of oral leukoplakia in a representative sample of the US population. Oral oncol.2004;40(2):158-63.
  • Ujpál M, Matos O, Bíbok G, et al. Diabetes and oral tumors in Hungary: epidemiological correlations. Diabetes care. 2004;27(3):770-4.
  • Sen MP, Shenoy N, Shenoy AK, et al. Diabetes Mellitus and Oral Cancer: Are They Connected? Indian J Oral Health Res. 2015;1(1):4.
  • Végh D, Bányai D, Hermann P, et al. Type-2 diabetes mellitus and oral tumors in hungary: a long-term comparative epidemiological study. Anticancer Res. 2017;37(4):1853-7.
  • Zhang H, Pelzer AM, Kiang DT, et al. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res.2007;67(1):391-7.
  • Le TN, Nestler JE, Strauss III JF, et al. Sex hormone-binding globulin and type 2 diabetes mellitus.Trends Endocrinol Metab. 2012;23(1):32-40.
  • Okutur SK. İki Eski Dost: Diyabet ve Kanser. Okmeydanı Tıp Derg.2015;31 (ek sayı):23-32.
  • Shi Y, Hu FB. The global implications of diabetes and cancer. Lancet. 2014;383(9933):1947.
  • Vigneri P, Frasca F, Sciacca L, et al. Diabetes and cancer. Endocr Relat Cancer.2009;16(4):1103-23.
  • Glass AG, Lacey Jr JV, Carreon JD, et al. Breast cancer incidence, 1980–2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status. J Natl Cancer Inst. 2007;99(15):1152-61.
  • Hemkens LG, Grouven U, Bender R, et al. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia. 2009;52(9):1732-44.
  • Thakkar B, Aronis KN, Vamvini MT, et al. Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies. Metabolism. 2013;62(7):922-34.
  • Joost HG. Diabetes and cancer: epidemiology and potential mechanisms. Diab Vasc Dis Res. 2014;11(6):390-4.
  • Tseng KS, Lin C, Lin YS, et al. Risk of head and neck cancer in patients with diabetes mellitus: a retrospective cohort study in Taiwan. JAMA Otolaryngol Head Neck Surg. 2014;140(8):746-53.
  • Saini R, Al-Maweri SA, Saini D, et al. Oral mucosal lesions in non oral habit diabetic patients and association of diabetes mellitus with oral precancerous lesions. Diabetes Res Clin Pract. 2010;89(3):320-6.
  • Mohsin SF, Ahmed SA, Fawwad A, et al. Prevalence of oral mucosal alterations in type 2 diabetes mellitus patients attending a diabetic center. Pakistan J Med Sci.2014;30(4):716.
  • Romero M, Seoane J, Varela-Centelles P, et al. Prevalence of diabetes mellitus amongst oral lichen planus patients. Clinical and pathological characteristics. Med Oral. 2002;7(2):121-9.
  • Yadiyal M, Shenoy N, Shenoy A, et al. Are Diabetics victims of oral cancer? Int J Bioassays. 2013;2(6):904-6.
  • Petrou‐Amerikanou C, Markopoulos A, Belazi M, et al. Prevalence of oral lichen planus in diabetes mellitus according to the type of diabetes. Oral Dis. 1998;4(1):37-40.
  • Borghelli RF, Pettinari IL, Chuchurru JA, Stirparo MA. Oral lichen planus in patients with diabetes. An epidemiologic study. Oral Surg Oral Med Oral Pathol. 1993;75(4):498–500.
  • Wu CH, Wu TY, Li CC, et al. Impact of diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma: a retrospective cohort study. Ann Surg Oncol. 2010;17(8):2175-83.

Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?

Yıl 2020, Cilt 42, Sayı 5, 249 - 253, 28.09.2020
https://doi.org/10.20515/otd.771272

Öz

Diyabetes Mellitus (DM) hiperglisemi ile karakterize, insülin sekresyonunda ve/veya insülin aktivitesinde bozulmayla ortaya çıkan metabolik bir hastalıktır. Tip 1 ve tip 2 olmak üzere başlıca iki gruba ayrılan DM’de uzun süren hiperglisemi sonucunda mikrovasküler ve makrovasküler komplikasyonlar ortaya çıkar. DM, oral mukozada da birçok immünolojik ve metabolik değişikliğe neden olarak, tükürük akışında azalma, periodontitis ve oral liken planus, lökoplaki gibi oral mukozal değişikliklere yol açabilir.Ağız kanserleri orta yaş ve üzerinde, yüksek morbidite ve mortalite oranına sahip sıklıkla erkeklerde saptanan karsinomlardır. Sigara, aşırı alkol tüketimi gibi etkenler ağız kanserlerinin etiyolojisinde önemli rol oynar.Yapılan çalışmalarda, tip 2 DM’nin kolon, meme, endometriyum ve pankreas dâhil olmak üzere birçok malignite için risk faktörü olduğu ve tip 2 DM’li hastalarda oral prekanseröz lezyonların görülme sıklığının arttığı belirlenmiştir. Bununla birlikte DM, ağız kanserlerinin oluşumuna zemin hazırlayabilir ve kanser prognozunun kötüleşmesine yol açabilir. Bu durumun ortaya çıkmasında hiperinsülinemi ve obezite gibi DM’nin etiyolojik faktörlerinin çeşitli mekanizmalarla rol oynadığı düşünülmekte ve DM tedavisinde kullanılan ilaçların da kanser üzerinde etkisi olduğu savunulmaktadır. Her ne kadar DM oral kanserler için risk faktörü olarak gösterilse de DM ile oral kanser arasındaki ilişki tam olarak açıklığa kavuşturulamamıştır.Bu derlemede DM ile oral kanserler arasındaki ilişki ve bu ilişkide rol oynayan olası patobiyolojik mekanizmalar makaleler ışığında tartışılmıştır.

Kaynakça

  • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37(Supplement 1):S81-S90.
  • Cicmil S, Mladenović I, Krunić J, et al. Oral alterations in diabetes mellitus. Balk J Dent Med. 2018;22(1):7-14.
  • Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral oncol. 2009;45(4-5):309-16.
  • Deschler DG, Richmon JD, Khariwala SS, et al. The “new” head and neck cancer patient—young, nonsmoker, nondrinker, and HPV positive: evaluation. Otolaryngology--Head and Neck Surg. 2014;151(3):375-80.
  • Majchrzak E, Szybiak B, Wegner A, et al. Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature. Radiol oncol.2014;48(1):1-10.
  • Genden EM, Ferlito A, Silver CE, et al. Contemporary management of cancer of the oral cavity. Eur Arch Otorhinolaryngol.2010;267(7):1001-17.
  • Wong T, Wiesenfeld D. Oral cancer. AustDent J.2018;63:S91-S9.
  • Skamagas M, Breen T, LeRoith D. Update on diabetes mellitus: prevention, treatment, and association with oral diseases. Oral diseases. 2008;14(2):105-14.
  • Verhulst MJ, Loos BG, Gerdes VE, et al. Evaluating all potential oral complications of diabetes mellitus. Front Endocrinol.2019;10.
  • Negrato CA, Tarzia O. Buccal alterations in diabetes mellitus. Diabetol Metab Syndr. 2010;2(1):3.
  • Giovannucci E, Harlan DM, Archer MC, et al. Diabetes and cancer: a consensus report. CA: a cancer journal for clinicians 2010;60(4):207-21.
  • Lipscombe LL, Goodwin PJ, Zinman B, et al. The impact of diabetes on survival following breast cancer. Breast Cancer Res Treat.2008;109(2):389-95.
  • Dikshit RP, Ramadas K, Hashibe M, et al. Association between diabetes mellitus and pre‐malignant oral diseases: A cross sectional study in Kerala, India. Int J Cancer. 2006;118(2):453-7.
  • Dietrich T, Reichart PA, Scheifele C. Clinical risk factors of oral leukoplakia in a representative sample of the US population. Oral oncol.2004;40(2):158-63.
  • Ujpál M, Matos O, Bíbok G, et al. Diabetes and oral tumors in Hungary: epidemiological correlations. Diabetes care. 2004;27(3):770-4.
  • Sen MP, Shenoy N, Shenoy AK, et al. Diabetes Mellitus and Oral Cancer: Are They Connected? Indian J Oral Health Res. 2015;1(1):4.
  • Végh D, Bányai D, Hermann P, et al. Type-2 diabetes mellitus and oral tumors in hungary: a long-term comparative epidemiological study. Anticancer Res. 2017;37(4):1853-7.
  • Zhang H, Pelzer AM, Kiang DT, et al. Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin. Cancer Res.2007;67(1):391-7.
  • Le TN, Nestler JE, Strauss III JF, et al. Sex hormone-binding globulin and type 2 diabetes mellitus.Trends Endocrinol Metab. 2012;23(1):32-40.
  • Okutur SK. İki Eski Dost: Diyabet ve Kanser. Okmeydanı Tıp Derg.2015;31 (ek sayı):23-32.
  • Shi Y, Hu FB. The global implications of diabetes and cancer. Lancet. 2014;383(9933):1947.
  • Vigneri P, Frasca F, Sciacca L, et al. Diabetes and cancer. Endocr Relat Cancer.2009;16(4):1103-23.
  • Glass AG, Lacey Jr JV, Carreon JD, et al. Breast cancer incidence, 1980–2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status. J Natl Cancer Inst. 2007;99(15):1152-61.
  • Hemkens LG, Grouven U, Bender R, et al. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study. Diabetologia. 2009;52(9):1732-44.
  • Thakkar B, Aronis KN, Vamvini MT, et al. Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies. Metabolism. 2013;62(7):922-34.
  • Joost HG. Diabetes and cancer: epidemiology and potential mechanisms. Diab Vasc Dis Res. 2014;11(6):390-4.
  • Tseng KS, Lin C, Lin YS, et al. Risk of head and neck cancer in patients with diabetes mellitus: a retrospective cohort study in Taiwan. JAMA Otolaryngol Head Neck Surg. 2014;140(8):746-53.
  • Saini R, Al-Maweri SA, Saini D, et al. Oral mucosal lesions in non oral habit diabetic patients and association of diabetes mellitus with oral precancerous lesions. Diabetes Res Clin Pract. 2010;89(3):320-6.
  • Mohsin SF, Ahmed SA, Fawwad A, et al. Prevalence of oral mucosal alterations in type 2 diabetes mellitus patients attending a diabetic center. Pakistan J Med Sci.2014;30(4):716.
  • Romero M, Seoane J, Varela-Centelles P, et al. Prevalence of diabetes mellitus amongst oral lichen planus patients. Clinical and pathological characteristics. Med Oral. 2002;7(2):121-9.
  • Yadiyal M, Shenoy N, Shenoy A, et al. Are Diabetics victims of oral cancer? Int J Bioassays. 2013;2(6):904-6.
  • Petrou‐Amerikanou C, Markopoulos A, Belazi M, et al. Prevalence of oral lichen planus in diabetes mellitus according to the type of diabetes. Oral Dis. 1998;4(1):37-40.
  • Borghelli RF, Pettinari IL, Chuchurru JA, Stirparo MA. Oral lichen planus in patients with diabetes. An epidemiologic study. Oral Surg Oral Med Oral Pathol. 1993;75(4):498–500.
  • Wu CH, Wu TY, Li CC, et al. Impact of diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma: a retrospective cohort study. Ann Surg Oncol. 2010;17(8):2175-83.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm DERLEMELER / REVIEWS
Yazarlar

Melike BAŞARAN (Sorumlu Yazar)
Kütahya Sağlık Bilimleri Üniversitesi
0000-0002-3311-1642
Türkiye

Yayımlanma Tarihi 28 Eylül 2020
Yayınlandığı Sayı Yıl 2020, Cilt 42, Sayı 5

Kaynak Göster

Bibtex @derleme { otd771272, journal = {Osmangazi Tıp Dergisi}, issn = {1305-4953}, eissn = {2587-1579}, address = {}, publisher = {Eskişehir Osmangazi Üniversitesi}, year = {2020}, volume = {42}, pages = {249 - 253}, doi = {10.20515/otd.771272}, title = {Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?}, key = {cite}, author = {Başaran, Melike} }
APA Başaran, M. (2020). Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü? . Osmangazi Tıp Dergisi , Ağız Kanserleri Özel Sayısı , 249-253 . DOI: 10.20515/otd.771272
MLA Başaran, M. "Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?" . Osmangazi Tıp Dergisi 42 (2020 ): 249-253 <https://dergipark.org.tr/tr/pub/otd/issue/56549/771272>
Chicago Başaran, M. "Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?". Osmangazi Tıp Dergisi 42 (2020 ): 249-253
RIS TY - JOUR T1 - Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü? AU - Melike Başaran Y1 - 2020 PY - 2020 N1 - doi: 10.20515/otd.771272 DO - 10.20515/otd.771272 T2 - Osmangazi Tıp Dergisi JF - Journal JO - JOR SP - 249 EP - 253 VL - 42 IS - 5 SN - 1305-4953-2587-1579 M3 - doi: 10.20515/otd.771272 UR - https://doi.org/10.20515/otd.771272 Y2 - 2020 ER -
EndNote %0 Osmangazi Tıp Dergisi Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü? %A Melike Başaran %T Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü? %D 2020 %J Osmangazi Tıp Dergisi %P 1305-4953-2587-1579 %V 42 %N 5 %R doi: 10.20515/otd.771272 %U 10.20515/otd.771272
ISNAD Başaran, Melike . "Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?". Osmangazi Tıp Dergisi 42 / 5 (Eylül 2020): 249-253 . https://doi.org/10.20515/otd.771272
AMA Başaran M. Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?. Osmangazi Tıp Dergisi. 2020; 42(5): 249-253.
Vancouver Başaran M. Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?. Osmangazi Tıp Dergisi. 2020; 42(5): 249-253.
IEEE M. Başaran , "Diyabetes Mellitus Ağız Kanserleri İçin Bir Risk Faktörü Mü?", Osmangazi Tıp Dergisi, c. 42, sayı. 5, ss. 249-253, Eyl. 2020, doi:10.20515/otd.771272

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