Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia resulting from defects in insulin secretion, insülin action, or both. In DM, which can be divided into two main groups, type 1 and type 2, microvascular and macrovascular complications occur a result of prolonged hyperglycemia.DM can lead to decreased salivary flow, periodontitis, and oral mucosal changes such as oral lichen planus, leukoplakia by causing many immunological and metabolic changes in the oral mucosa. Oral cancers are carcinomas that are found in middle age and over, frequently in males with high morbidity and mortality rates. Factors such as smoking and alcohol abuse play important role in the etiology. In the reported studies, it has been determined that type 2 DM is a risk factor for several cancers such as breast, endometrium, and pancreas, and the incidence of oral precancerous lesions increases with type 2 DM. Also, DM can lay the groundwork formation of oral cancers and to cause the deterioration of cancer prognosis. It has been thought that the etiological factors of DM such as hyperinsulinemia and obesity play a role in the emergence of this condition by various mechanisms and the drugs used in the management of DM effect on cancer. Although DM has been shown as a risk factor for oral cancers, the relationship between DM and oral cancer has not been fully clarified. In this review, the relationship between DM and oral cancers and possible pathobiological mechanisms in this relationship are discussed in the light of reported articles.
Diabetes mellitus, oral cancer, precanserous lesion; risk factor
Diyabetes mellitus; oral kanser; prekanseröz lezyon; risk faktörü
Birincil Dil | Türkçe |
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Konular | Sağlık Kurumları Yönetimi |
Bölüm | DERLEMELER / REVIEWS |
Yazarlar | |
Yayımlanma Tarihi | 28 Eylül 2020 |
Yayımlandığı Sayı | Yıl 2020 Ağız Kanserleri Özel Sayısı |