Marmara Bölgesinde Yaşayan Atopik Çocukların Aeroalerjen Duyarlılıklarının Değerlendirilmesi

Yıl 2024, Cilt: 46 Sayı: 5, 775 - 780, 12.09.2024

Ömer Akçal , Gizem Atakul

https://doi.org/10.20515/otd.1497592

Öz

Marmara bölgesinde yaşayan ve atopik yakınmalar ile kliniğimize başvurmuş hastaların aeroalerjen duyarlılıklarının dağılımını incelemek istedik. Çocuk İmmünolojisi ve Alerji Hastalıkları Polikliniği’ne Nisan 2023-Nisan 2024 tarihleri arasında başvuran 0-18 yaş arası hastalardan deri prickprik test (DPT) uygulanmış olgular geriye dönük olarak değerlendirildi. Olguların % 40,2’ si (n=355) nonsensitize, % 46,2’ si (n=408) monosensitize, % 13,6’ sı (n=120) polisensitize idi. Olgularımızda en sık (% 44,3) saptanan aeroalerjen ev tozu akarlarıydı. Bunu sırasıyla polen, hayvan tüyü epiteli ve küf takip ediyordu. Alerjik hastalıklarda primer korunma önlemleri tedavinin ilk basamağını oluşturmaktadır. Bu bölgede yaşayan olgularda en sık aeroalerjenin bilinmesi duyarlanma öncesinde bile farkındalık sağlamaktadır. DPT için alerjen paneli oluşturulurken bölgeye özgü duyarlılık sıklığı mutlaka göz önüne alınmalıdır.

Anahtar Kelimeler

Alerji, Aeroalerjen, Deri prick test, Atopi

Evaluation Of Aeroallergen Sensitivities of Atopic Children Living In The Marmara Region

Öz

We wanted to examine the distribution of aeroallergen sensitivities of patients living in the Marmara region and applying to our clinic with atopic complaints. Cases who underwent skin prick test (SPT) among patients aged 0-18 years who applied to the Pediatric Allergy and Immunology Polyclinic between April 2023 and April 2024 were evaluated retrospectively. 40.2% (n=355) of the cases were nonsensitized, 46.2% (n=408) were monosensitized, and 13.6% (n=120) were polysensitized. The most frequently detected aeroallergen (44.3%) in our cases was house dust mites. The other common allergens were pollen, animal dander and mold, respectively. The first step of the treatment in allergic disease is primary prevention measures. Identifying the regional distribution frequencies of aeroallergens can contribute to the prevention of diseases by raising awareness and taking precautions before sensitization. The regional distribution frequencies of aeroallergen sensitivities must be taken into consideration when setting an allergen panel for SPTs.

Anahtar Kelimeler

allergy, aeroallergen, skin prick test, atopy

Kaynakça

• 1. Venkatesan P. 2023 GINA report for asthma. Lancet Respir Med. 2023 Jul;11(7):589.
• 2. Nevis IF, Binkley K, Kabali C. Diagnostic accuracy of skin-prick testing for allergic rhinitis: a systematic review and meta-analysis. Allergy Asthma Clin Immunol. 2016 Apr 27;12:20.
• 3. Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, Passalacqua G, Savi E, Ebo D, Gómez RM, Luengo Sánchez O, Oppenheimer JJ, Jensen-Jarolim E, Fischer DA, Haahtela T, Antila M, Bousquet JJ, Cardona V, Chiang WC, Demoly PM, DuBuske LM, Ferrer Puga M, Gerth van Wijk R, González Díaz SN, Gonzalez-Estrada A, Jares E, Kalpaklioğlu AF, Kase Tanno L, Kowalski ML, Ledford DK, Monge Ortega OP, Morais Almeida M, Pfaar O, Poulsen LK, Pawankar R, Renz HE, Romano AG, Rosário Filho NA, Rosenwasser L, Sánchez Borges MA, Scala E, Senna GE, Sisul JC, Tang MLK, Thong BY, Valenta R, Wood RA, Zuberbier T. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020 Feb 25;13(2):100080.
• 4. Zemmer F, Cenk E, Dahl Å, Galán C, Ozkaragoz F. A multidisciplinary approach of outdoor aeroallergen selection for Skin Prick Testing in the geographical area of Greater Istanbul. Eur Ann Allergy Clin Immunol. 2022 Jan;54(1):34-42.
• 5. Djukanovic R, Feather I, Gratziou C, Walls A, Peroni D, Bradding P, et al. Effect of natural allergen exposure during the grass pollen sea-son on airways inflammatory cells and asthma symptoms. Thorax 1996;51:575-81.
• 6. Mari A, Rasi C, Palazzo P, Scala E. Allergen databases: current status and perspectives. Curr Allergy Asthma Rep. 2009;9(5):376–383.
• 7. Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, Passalacqua G, Savi E, Ebo D, Gómez RM, Luengo Sánchez O, Oppenheimer JJ, Jensen-Jarolim E, Fischer DA, Haahtela T, Antila M, Bousquet JJ, Cardona V, Chiang WC, Demoly PM, DuBuske LM, Ferrer Puga M, Gerth van Wijk R, González Díaz SN, Gonzalez-Estrada A, Jares E, Kalpaklioğlu AF, Kase Tanno L, Kowalski ML, Ledford DK, Monge Ortega OP, Morais Almeida M, Pfaar O, Poulsen LK, Pawankar R, Renz HE, Romano AG, Rosário Filho NA, Rosenwasser L, Sánchez Borges MA, Scala E, Senna GE, Sisul JC, Tang MLK, Thong BY, Valenta R, Wood RA, Zuberbier T. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020 Feb 25;13(2):100080..
• 8. Heinzerling L, Mari A, Bergmann KC, Bresciani M, Burbach G, Darsow U, Durham S, Fokkens W, Gjomarkaj M, Haahtela T, Bom AT, Wöhrl S, Maibach H, Lockey R. The skin prick test - European standards. Clin Transl Allergy. 2013 Feb 1;3(1):3.
• 9. Başaran Abdurrahman E, Karataş Torun N, Kocacık Uygun D F, Bıngöl A. Distribution Of Aeroallergens On Skin Prick Tests Of Atopic Children Living İn The Akdeniz Region, Turkey. Asthma Allergy Immunol 2018;16:132-137.
• 10. Sipahi Cimen S, Atakul G. Elazığ ve Malatya yörelerinde yaşayan astım ve alerjik rinit tanılı çocuklarda deri prik testlerindeki aeroalerjen dağılımları. Çocuk Dergisi - Journal of Child 2023;23(1):35-41.
• 11. Bodur M, Canites Y, Cekic S, Ocakoglu G, Sapan N. Güney Marmara Bölgesindeki alerjik rinitli çocuklarda mantar alerjenlerine duyarlılık oranlarının araştırılması. Çocuk Dergisi - Journal of Child 2021;21(2):111-118.
• 12. Hazar Sayar E. Aeroallergen Sensitivity of Atopic Children in Alanya Region. Selcuk Med J 2020;36(3): 226-231.
• 13. Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M, et al.. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol. (2004) 113:86–93.
• 14. Paus Jenssen ES, Cockcroft DW. Sex differences in asthma, atopy and airway hyperresponsiveness in a university population. Ann Allergy Asthma Immunol 2003;91:34-7.