HIV INTEGRASE INHIBITORS

Öz

HIV infection is incredibly detrimental and fatal to people. Unfortunately, despite recent advancements and medications, it has not yet been completely eradicated. Opportunistic infections are added to the list of disorders in AIDS (Acquired Immune Deficiency Syndrome), an infectious disease that develops as a result of an impaired immune system. In 2021, there were 38.4 million [33.9-43.8 million] persons living with HIV worldwide, up from 26.0 million [22.9-29.7 million] in 2000. The benefits of vastly expanded access to antiretrovirals, which have contributed to decreasing the number of individuals dying from HIV-related causes, can be observed in the persistence of HIV transmission despite declines in incidence. HIV-1 integration (IN), a critical stage in the integration of viral DNA into the host genome, is vital for retroviral replication. Numerous HIV integrase inhibitors have been created since the identification of this pathway, including Raltegravir, Elvitegravir, Dolutegravir, Bictegravir, and Cabotegravir. HIV integrase inhibitors and their synthesis are covered in this review.

Anahtar Kelimeler

• Hiv
• Integrase inhibitors
• AIDS

Kaynakça

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