Adipose Tissue As an Endocrine Organ: A Perspective From Adiponectine and Irisin

Abstract

In recent years, adipose tissue has been defined as a new endocrine organ via its paracrine, autocrine and endocrine effects. With the secreted hormones and cytokines it plays a major role in the regulation and integration of metabolism. The metabolic pathways involvin these hormones and cytokines including insulin sensitivity show a connection with the pathogenesis of obesity, type II diabetes mellitus, metabolic syndrome, inflammatory diseases, many chronic diseases and even cancer. Adipokines or adipocytokines are cytokines secreted by adipose tissue. In this mini-review, information about two of the most important adipokines, adiponectin and irisin, is given and their important effects are presented to the attention of the reader.

Keywords

• Adiponectin
• adipose tissue
• endocrine
• irisin

Kaynakça

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