Combination of Alginate and Chitosan Polymers in the Preparation of Nanoparticles-A Mini Review

Yıl 2021, Cilt: 1 Sayı: 1, 19 - 26, 17.01.2023

Meltem Çetin

Öz

Natural polymers, commonly include polysaccharides (chitin/chitosan, hyaluronic acid derivatives, alginate, etc.) and proteins (albumin, collagen, etc.), are non-toxic and biocompatible biomaterials widely used in various biomedical applications (such as drug and/or imaging agent delivery system, tissue regeneration scaffolds, as excipients in pharmaceutical formulations). Especially, alginate and chitosan are widely used for the preparation of drug delivery systems. Unfortunately, the primary drawback of both alginate and chitosan is the lack of strong mechanical properties. However, using the combination of these polymers can enhance their mechanical properties. Besides, the alginate-chitosan nanoparticles had higher drug encapsulation and a slower drug release due to the polyelectrolyte complex structure formed by the interaction between chitosan and alginate.

Anahtar Kelimeler

Alginate, chitosan, nanoparticles, polyelectrolyte complex

Kaynakça

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