Ani İşitme Kaybında C-Reaktif Protein Albümin Oranı ve Hematolojik Parametrelerin Prognostik Değeri

Yıl 2023, , 158 - 163, 01.11.2023

Muhammed Gazi Yıldız , İsrafil Orhan , Adem Doğaner

https://doi.org/10.38175/phnx.1239411

Öz

Amaç: Çalışmanın amacı Ani İşitme Kaybının(AİK) prognozunda C reaktif protein / albümin oranı(CAO) ve hemoglobin, nötrofil, lenfosit, trombosit, ortalama trombosit hacmi(MPV), Nötrofil/Lenfosit oranı(NLO), Trombosit / Lenfosit oranı(TLO) ve Sistemik İmmun İnflamasyon İndeksi(Sİİ) gibi hematolojik parametrelerin etkisini araştırmaktır.
Gereç ve Yöntemler: Çalışma 66 AİK tanısı olan hasta grubu ve 66 sağlıklı kontrol grubu olacak şekilde planlandı. Hastaların tedavi öncesi hemogram parametreleri ve işitme testleri incelendi. Ani işitme kaybı olan hastalar tedavi sonrası iyileşenler ve iyileşmeyenler olarak sınıflandırıldı. Gruplar arası CAO ve hematolojik parametreler karşılaştırıldı.
Bulgular: Hasta grupta CRP hariç diğer parametreler istatistiksel olarak anlamlı saptandı. Recevier Operator Curve(ROC) analizinde hasta grupta NLO, TLO, Sİİ, MPV ve CAO değerlerinin AİK grubunda ayrım gücü istatistiksel olarak anlamlı idi. Ayrıca AİK grubunda iyileşmeyenlerde ise nötrofil dışındaki diğer parametreler istatistiksel olarak anlamlı idi. ROC analizinde ise NLO, TLO, Sİİ, MPV ve CAO değerleri istatistiksel anlamlı yüksek saptandı.
Sonuç: Ani işitme kaybı olan hastalarda maliyeti düşük, kolay elde edilen CAO, NLO, TLO,MPV ve Sİİ prognozun belirlenmesinde prediktif gösterge olarak kullanılabilir.

Anahtar Kelimeler

Ani işitme kaybı, C Reaktif Protein Albümin Oranı, Hematolojik parametreler, Sudden Hearing Loss, C Reactive Protein Albumin Ratio, Hematological Parameters

The Prognostic Importance of C-Reactive Poretin Albumin Ratio and Hematological Parameters in Sudden Hearing Loss

Öz

Objective: The aim of the study was to investigate the effect of hemoglobin, neutrophil, lymphocyte, platelet, mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), C reactive protein to albumin ratio (CAR), systemic immun inflamation index(SII) on the prognosis of sudden hearing loss.
Material and Methods: This study was planned as 66 patient group with AIC and 66 healthy control group.Routine hemogram parameters and hearing tests of the patients before treatment and control group were examined. patients with sudden hearing loss were classified as those who recovered after treatment and those who did not. CAR and hematological parameters were compared between groups.
Results: Except for CRP, other parameters were statistically significant in the patient group. In the Recevier Operator Curve (ROC) analysis, the discrimination power of NLR, TLR, SII, MPV and CAO values in the patient group was statistically significant. In addition, other parameters other than neutrophils were statistically significant in those who did not improve in the AIK group. NLR, TLR, SII, MPV and CAR values were found to be statistically significantly higher in the ROC analysis.
Conclusion: Cost-effective and easily obtained CAR, NLR, TLR, MPV and SII can be used as predictive markers in determining the prognosis in patients with sudden hearing loss.

Anahtar Kelimeler

Sudden Hearing Loss, C Reactive Protein Albumin Ratio, Hematological Parameters

Kaynakça

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