Renal Hücreli Karsinom Vakalarının Patoloji Raporlarında Taranması

Öz

Amaç: Böbrekte görülen renal hücreli karsinom tüm malign tümörlerin % 1- 3’ ünü teşkil eder. Renal hücreli karsinomların histolojik olarak %80’ ini berrak hücreli tip oluşturmaktadır. Renal hücreli karsinomlarda nükleus ile alakalı olan Fuhrman derecelendirme sistemi, prognozu tahmin etmede önemli bir belirteçtir. Bu yazıda 2015- 2022 yılları arasındaki böbrek hücreli karsinom tanılı vakalar patoloji raporları üzerinden hastane dijital ortamında taranmış elde edilen veriler ve aralarındaki ilişkiler literatür eşliğinde tartışılmıştır. Gereç ve Yöntem: Ocak 2015- ocak 2022 yılları arasındaki 318 renal hücreli karsinom vakası hastane dijital ortamında taranarak belirlendi. İstatistiksel analiz için SPSS 15.0 for Windows programı kullanıldı. Bağımsız gruplarda oranlar Ki Kare testi ile karşılaştırıldı. İstatistiksel alfa anlamlılık seviyesi p< 0,05 olarak kabul edildi. Bulgular: 213’ ü erkek ve 105’ i kadın olmak üzere 318 renal hücreli karsinom vakası vardı. Tümörlerin 156’ sı sol; 155’ i sağ tarafta yerleşmişti. Histolojik tiplerden en sık görüleni berrak tip böbrek hücreli karsinom olup sayısı 195 (% 61,3)’ ti. En sık Fuhrman derece 2 görülmüş ve sayısı 137’ ti. 195 berrak hücreli renal hücreli karsinomun 190’ında derece belirtilmişti. Sonuç: 213’ ü erkek ve 105’ i kadın olmak üzere erkeklerde kadınlardan yaklaşık iki kat daha fazla vaka görüldü. Histolojik tiplerde Fuhrman derecelerinde istatistiksel olarak anlamlı fark tespit edildi (p=0,002). Grade 1 berrak papiller tipte daha yüksek, grade 2 ise berrak tip ve papiller renal hücreli karsinomda daha yüksekti. Nekroz oranlarında histolojik alt tiplere göre istatistiksel olarak anlamlı fark tespit edildi (p=0,043).

Anahtar Kelimeler

• Renal hücreli karsinom
• Berrak hücreli Renal hücreli karsinom
• prognoz

Screening of Renal Cell Carcinoma Cases in Pathology Reports

Öz

Objective: Renal cell carcinoma in the kidney accounts for 1-3% of all malignant tumors. Histologically, 80% of renal cell carcinomas are clear cell type. The Fuhrman grading system is related to the nucleus in renal cell carcinomas. Furthermore, it is a significant indicator in predicting prognosis. This study scanned the cases diagnosed with renal cell carcinoma between 2015 and 2022 from the hospital’s digital environment from pathology reports and discussed the relationships between them together with the literature. Material and Method: The hospital’s digital environment had 318 renal cell carcinoma cases between January 2015 and January 2022. SPSS 15.0 for Windows program was used for statistical analysis. The ratios in independent groups were compared with the Chi-Square test. Statistical alpha significance level was accepted as p< 0.05. Results: There were 318 cases of renal cell carcinoma, 213 were male, and 105 were female. 156 of the tumors were located on the left; whereas 155 were on the right side. The most common histological type was clear-type renal cell carcinoma, with 195 incidences (61.3%). Fuhrman grade 2 was the most common and the number was 137. Grading was performed in 190 of 195 clear cell renal cell carcinomas. Conclusion: There were approximately twice as many cases in men as in women, with 213 men and 105 women. There was a statistically significant difference between Fuhrman grades in different histology types (p=0.002). Grade 1 was higher in clear papillary, grade 2 was higher in clear type and papillary renal cell carcinoma. According to histological subtypes, necrosis rates differed significantly (p=0.043).

Anahtar Kelimeler

• Renal cell carcinoma
• clear cell carcinoma
• prognosis

Kaynakça

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