Reaktif Hiperplazi ve Rekürrent Tonsillitlerde Lusigenin - Serbest Oksijen Radikallerinin Karşılaştırılması

Yıl 2019, , 15 - 19, 01.11.2019

Ali Seyed Resuli

https://doi.org/10.38175/phnx.615142

Cited By: 1

Öz

Giriş ve Amaç: kronik tonsilite bağlı Tonsillektomi
(T), Kulak Burun Boğaz hekimlerinin en sık yaptıkları ameliyatlardandır. Halen
kronik tonsillit ve tonsil hipertrofisi patogenizindeki faklılıklar tam olarak
bilinmemektedir.  Tonsil hipertrofisi ve
kronik tonsillit hastalarında serbest okisjen radikallerinin seviyelerinin
karşılaştırılması ve serbest okisjen radikallerinin kronik tonsiillit
patogenezindeki rolünün araştırılması bu çalışmada amaçlanmıştır.

Gereç ve yöntem: Çalışmaya Paradise kriterlerine göre
Tonsillektomi (T) endikasyonu konulan ve opere edilen 40 hasta alındı.
Operasyon materyallerine histopatolojik inceleme ve serbest oksijen
radikalleriden süperoksit ölçümleri yapıldı.

Bulgular: Histopatolojik bulgulara göre; 28
(%70) hastadan oluşan aktif yada kronik tonsilitli diğeri ise 12 (%30) hastadan
oluşan reaktif folliküler hiperplazili olarak iki gruba ayrıldı. Kronik
tonsilitli grubun lusigenin-serbest oksijen radikal (Luc-SOR) değeri 82.29+-32.3 Auc,  reaktif 
folliküler hiperplazi’li  grubun
ise 50.76+-7.95 Auc bulundu. Luc-SOR değeri karşılaştırıldığında kronik
tonsillitli grupta anlamlı derecede (p=0.001) yüksek olduğu belirlendi.

Sonuç: Serbest
oksijen radikalleri tonsiller patolojilerde önemli rol oynamaktadır. Tonsil
hipertrofisi ve kronik tonsillit hastalarının tonsil dokusundan ölçülen Luc-SOR
değerlerinin farklı olması bu iki hastalığın patogenezinin de farklı olduğunu
göstermektedir.

Anahtar Kelimeler

Tonsillektomi, Kronik Tonsilit, Serbest Oksijen Radikalleri

A Comparison of Lucigenin - Free Oxygen Radicals in Reactive Hyperplasia and Recurrent Tonsillitis

Öz

Aim and Background: Today, tonsillectomy (T) used for chronic tonsillitis
is among the most common surgery type that ear, nose, and throat physicians
perform. The differences in the pathogenesis of chronic tonsillitis and tonsil
hypertrophy are still unknown. This study aimed to compare the levels of free
oxygen radicals in patients with tonsil hypertrophy and chronic tonsillitis and
to investigate the role of free oxygen radicals in the pathogenesis of chronic
tonsillitis.

Materials and Method: The study included 40 patients who had chronic
tonsillitis indications based on Paradise criteria, and T was performed.
Operation materials were histopathologically examined, and their free oxygen
radicals (FOR) levels were measured.

Results:
Based on the histopathological results, the participants were divided into two
groups: one including 28 (70%) patients who had active or chronic tonsillitis,
the other including 12 (30%) patients with reactive follicular
hyperplasia.  Lucigenin - free oxygen
radicals (Luc-FOR) levels of the group with chronic tonsillitis and that of the
group with reactive follicular hyperplasia were 82.29±32.3 Auc and 50.76±7.95
Auc, respectively.  Luc-FOR values were
found to be significantly higher in the group with chronic tonsillitis
(p=0.001).

Conclusion: Free oxygen radicals play an essential role in
tonsillar pathologies. Differences in the Luc-FOR levels measured from
tonsillar tissue in patients with tonsil hypertrophy and chronic tonsillitis
demonstrate that the pathogenesis of these two diseases is different.

Anahtar Kelimeler

tonsillectomy, chronic tonsillitis, free oxygen radicals

Kaynakça

• 1. Wagner S, Jung H, Nau F, Schmitt HJ. Relevance of infectious diseases in pediatric practice. Klin Padiatr. 1993 Jan-Feb;205(1):14-7. https://doi: 10.1055/s-2007-1025190.
• 2. Cowan DL, Hibbert J. Acute and chronic infection of pharynx and tonsils, Scott Brown’s Otolaryngology, Volume 5, Chapter 4, 6th edition, 1997.
• 3. Piacenti GL, Peroni DG, Blasi F, et al. Atypical bacteria in adenoides and tonsilis of children requiring adenotonsillectomy. Acta Otolaryngol. 2010; 130(5): 620-5. https://doi: 10.3109/00016480903359921.
• 4. Bicknell PG. Role of adenotonsillectomy in the management of pediatric ear, nose and throat infections. Pediatr Infect Dis J 1994; 13(1 Suppl 1): S75-8.
• 5. Gustafsson A, İto H, Asman B, Bergstrom K. (2006). Hyper-reactive mononuclear cells and neutrophils in chronic periodontitis. J Clin Periodontol, 33:126-129. https://doi: 10.1111/j.1600-051X.2005.00883.x.
• 6. Arvind P, Malaya KS, Diana O, Sanjay B. NADPH oxidases: an overview from stucture to innate immunity-associated pathologics. Cell Molec İmmunol. 2015;12:5-23. https:// doi: 10.1038/cmi.2014.89.
• 7. Claesson R, Johanson E, Carlsson J.(1994). Oxygen-dependent modulation of release and activity of polymorphonuclear leukocyte granule products. Oral Microbiol Immunol, 9:81-87. https://doi.org/10.1111/j.1399-302X.1994.tb00039.x.
• 8. Dennison DK, Van Dayke TE.(1997). The acute inflammatory response and the role of phagocytic cells in periodontal health and disease. Periodontol 2000, 14:54-78.
• 9. Cheeseman KH, Slater TF. (1993): An introduction to free radical biochemistry. Brit Med Bull 49(3):481-493. https://doi.org/10.1093/oxfordjournals.bmb.a072625.
• 10. Karahatay S, Akçam T. Tonsillektomi ve adenoidektomi endikasyonları. Türkiye Klinikleri J Surg Med Sci 2005; 1:12-15.
• 11. Paradise JL, Bluestone CD, Bachman RZ, Colborn DK, Bernard BS, Tatlor FH, Rogers KD, Schwarzbach RH, Stool SE, Friday GA, et al. Efficacy of tonsillectomy for recurrent thorat infection in severely affected children. Results of parallel randomized and nonrandomized clinical trials. N Engl J Med. 1984 Mar 15;310(11):674-83. https://doi: 10.1056/NEJM198403153101102.
• 12. Münzel T, Afanas’ev İB, Kleschyov AL, Harrison DG. (2002). Detection of superoxide in vascular tissue. Arterioscler Thromb Vasc Biol, 22:1761-1768. https://doi: 10.1161/01.ATV.0000034022.11764.EC.
• 13. Davies GR, Simmonds NJ, Stevens TRJ, Grandison A, Blake DR Rampton DS. (1992). Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut, 33:1476-1472.
• 14. Erickson BK, Larson DR, St Sauver JL, et al. Changes in incidence and indications of tonsillectomy and adenotonsillectomy, 1970-2005. Otolaryngol Head Neck Surg 2009; 140:894-901. https://doi: 10.1016/j.otohns.2009.01.044.
• 15. Faramarzi A, Kadivar MR, Heydari ST, Tavasoli M. Assessement of the consensus about tonsillectomy and/or adenoidectomy among pediatricians and otolaryngologists. İnt J Pediatr Otorhinolaryngol 2010; 74:133-136. https://doi: 10.1016/j.ijporl.2009.10.024.
• 16. Baugh RF, Archer SM, Mitchell RB, et al. Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 2011; 144(I suppl):S1-30. https://doi.org/10.1177/0194599810389949.
• 17. İnal ME, Kanbak G, Sunal E. Antioxdant enzyme activites and malondialdehyde levels related to aging. Clin Chim Acta 2001; 305:75-80.
• 18. Shukla GK, Mahajan A, Pandey S, et al. Astudy of free radicals and scavening enzyme in tonsillitis. Boll Chim Form 1996-135:653-5. https://doi: 10.1016/S0194-5998(03)00630-2.
• 19. Delibaş N, Doğru H, Döner F, Gedikli O, Tarhan V. Presbiakuzi ve serbest radikaller. Kulak Burun Boğaz ve Baş Boyun Cerrahisi Dergisi 1996;4:811.
• 20. Chapple ILC, Matthews JB.(2007). The role of reactive oxygen and antioxidant species in periodontal tissuse destruction. Periodontol 2000, 43;160-232. https://doi: 10.1111/j.1600-0757.2006.00178.x.
• 21. Nordberg J, Arner ESJ.(2001): Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med, 31:1287-1312. https://doi.org/10.1016/S0891-5849(01)00724-9.
• 22. Battino M, Bulon P, Wilson M, Newman H.(1999). Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidats to free radicals and reavtive oxygen species. Crit Rev Oral Biol Med, 10(4):458-476. https://doi: 10.1177/10454411990100040301.
• 23. Sardesal VM. Role of antioxidants in health maintenance. Nutr Clin Pract 1995; 10: 19-25. https://doi: 10.1177/011542659501000119.
• 24. Levine AS, Sun L, Tan R, et al. The oxidative DNA damage response: a review of research undertaken with Tsinghua and Xiangya students at the University of Pittsburg. Sci China Life Sci. 2017;60:1077-1080. https://doi: 10.1007/s11427-017-9184-6.
• 25. Burton MJ, Glasziou PP. Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev. 2009; 21;(1):CD001802. https://doi: 10.1002/14651858.CD001802.pub3.
• 26. Silva S, Ouda M, Mathanakumara S, et al. Tonsillectomy under threat: auditing the indications for performing tonsillectomy. J Laryngol Otol. 2012; 126(6): 609-11. https://doi: 10.1017/S0022215112000643.