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PULMONER EMBOLİ 2019

Yıl 2019, Cilt: 1 Sayı: 1, 51 - 63, 01.11.2019

Öz

Pulmoner emboli
(PE) yüksek mortaliteye sahip olan ve acil servislerde sık şüphelenilen
olgulardan biridir.
Acil servislerde şüphe/tanı oranı düşük ama
mortalitesi yüksektir. Nonspesifik klinik bulgular ve geniş spektrumda semptoma
sahip olduğundan dolayı tanısı zordur. Klinik tecrübeye
bağlı yargı, klinik tahmin skorlama sistemleri, dışlama kriterleri ve D-dimer
testi tanının dışlanmasında önemlidir. Transtorasik ekokardiyografi ve bilgisayarlı
tomografi pulmoner anjiyografi (BTPA) özellikle hemodinamik instabil olgularda hızlı
tanıda önemlidir. Ventilasyon/Perfüzyon sintigrafisi BTPA çekilemeyen ve radyasyondan
kaçınmak istediğimiz hastalarda faydalıdır. PE’ erken risk sınıflaması ve instabil
hastalarda hızlı reperfüzyon tedavisi hayat kurtarıcıdır. Bu derlemede acil
servisin kırmızı bayraklarında olan PE’ nin tanı ve tedavisi hakkında European
Respiratory Society (ERS) 2019 PE klavuzu eşliğinde bilgiler verilmiştir.

Kaynakça

  • 1. Raskob GE, Angchaisuksiri P, Blanco AN, et al. for the ISTH Steering Committee for World Thrombosis Day. Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol 2014;34:2363-71.
  • 2. Wendelboe AM, McCumber M, Hylek EM, et al. for the ISTH Steering Committee for World Thrombosis Day. Global public awareness of venous thromboembolism. J Thromb Haemost 2015;13:1365-71.
  • 3. Wendelboe AM, Raskob GE. Global burden of thrombosis: epidemiologic aspects. Circ Res 2016;118:1340-1347.
  • 4. Cohen AT, Agnelli G, Anderson FA, et al. VTE Impact Assessment Group in Europe (VITAE). Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost 2007;98:756-764.
  • 5. Crous-Bou M, Harrington LB, Kabrhel C. Environmental and genetic risk factors associated with venous thromboembolism. Semin Thromb Hemost 2016;42(8): 808–820. DOI:10.1055/s-0036-1592333.
  • 6. Arseven O, Sevinç C, Ekim N, et al. Pulmoner Tromboembolism Tanı ve Tedavi Uzlaşı Raporu. Türk Toraks Derneği, 2015.
  • 7. Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism Circulation 2003;107:I9 I16.
  • 8. Yılmaz S, Topçu F, Selimoğlu Şen H, Abakay Ö, Yılmaz Z. Pulmoner emboli tanısında Wells klinik skorlaması ile yüksek D-dimer seviyesinin kombinasyonu. Journal Clinical and Experimental Investigations 2014;5(4):557-562.
  • 9. Smulders YM. Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc Res 2000;48:23-33.
  • 10. Konstantinides SV, Meyer G, Becattini C et al. 2019 Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). European Heart Journal 2019;00:1-61 DOI:10.1093/eurheartj/ehz405.
  • 11. Marcus JT, Gan CT, Zwanenburg JJ, et al. Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling. J Am Coll Cardiol 2008;51:750-757.
  • 12. Mauritz GJ, Marcus JT, Westerhof N, Postmus PE, Vonk-Noordegraaf A. Prolonged right ventricular post-systolic isovolumic period in pulmonary arterial hypertension is not a reflection of diastolic dysfunction. Heart 2011;97:473-478.
  • 13. Konstantinides S, Geibel A, Kasper W, Olschewski M, Blumel L, Just H. Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism. Circulation 1998;97:1946-1951.
  • 14. Harjola VP, Mebazaa A, Celutkiene J, et al. Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail 2016;18:226-241.
  • 15. Stein PD, Terrin ML, Hales CA, et al. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest 1991;100:598.
  • 16. Pollack CV, Schreiber D, Goldhaber SZ, et al. Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department: initial report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry. J Am Coll Cardiol 2011;57:700-706.
  • 17. Ammar H, Ohri C, Hajouli S, et al. Prevalence and Predictors of Pulmonary Embolism in Hospitalized Patients with Syncope. South med J 2019;112(8):421-427. DOI:10.14423/SMJ.0000000000001009.
  • 18. Rodger MA, Carrier M, Jones GN, et al. Diagnostic value of arterial blood gas measurement in suspected pulmonary embolism. Am J Respir Crit Care Med 2000;162:2105-2108.Stein PD, Goldhaber SZ, Henry JW. Alveolar-arterial oxygen gradient in the assessment of acute pulmonary embolism. Chest 1995;107:139.
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PULMONARY EMBOLISM 2019

Yıl 2019, Cilt: 1 Sayı: 1, 51 - 63, 01.11.2019

Öz

Pulmonary embolism
(PE) is one of the most suspected cases in the emergency department with high
mortality. The suspicion/diagnosis ratio is low in emergency departments but itsmortality
is high. Diagnosis of PE is difficult because it has nonspecific clinical
findings and a broad spectrum of symptoms. Judgment based on clinical
experience, prediction rules, exclusion criteria, and D-dimer test are
important in excluding the diagnosis. Transthoracic echocardiography and
computed tomography pulmonary angiography (CTPA) are important in rapid
diagnosis, especially in patients with hemodynamic instability. Ventilation /
Perfusion scintigraphy is useful in patients who cannot receive BTPA and want
to avoid radiation. Early risk classification of PE and rapid reperfusion
therapy in unstable patients are life-saving. In this review, information about
the diagnosis and management of PE, which is one of the red flags of the
emergency department, is provided by the European Respiratory Society (ERS)
2019 guideline for PE.

Kaynakça

  • 1. Raskob GE, Angchaisuksiri P, Blanco AN, et al. for the ISTH Steering Committee for World Thrombosis Day. Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol 2014;34:2363-71.
  • 2. Wendelboe AM, McCumber M, Hylek EM, et al. for the ISTH Steering Committee for World Thrombosis Day. Global public awareness of venous thromboembolism. J Thromb Haemost 2015;13:1365-71.
  • 3. Wendelboe AM, Raskob GE. Global burden of thrombosis: epidemiologic aspects. Circ Res 2016;118:1340-1347.
  • 4. Cohen AT, Agnelli G, Anderson FA, et al. VTE Impact Assessment Group in Europe (VITAE). Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost 2007;98:756-764.
  • 5. Crous-Bou M, Harrington LB, Kabrhel C. Environmental and genetic risk factors associated with venous thromboembolism. Semin Thromb Hemost 2016;42(8): 808–820. DOI:10.1055/s-0036-1592333.
  • 6. Arseven O, Sevinç C, Ekim N, et al. Pulmoner Tromboembolism Tanı ve Tedavi Uzlaşı Raporu. Türk Toraks Derneği, 2015.
  • 7. Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism Circulation 2003;107:I9 I16.
  • 8. Yılmaz S, Topçu F, Selimoğlu Şen H, Abakay Ö, Yılmaz Z. Pulmoner emboli tanısında Wells klinik skorlaması ile yüksek D-dimer seviyesinin kombinasyonu. Journal Clinical and Experimental Investigations 2014;5(4):557-562.
  • 9. Smulders YM. Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc Res 2000;48:23-33.
  • 10. Konstantinides SV, Meyer G, Becattini C et al. 2019 Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). European Heart Journal 2019;00:1-61 DOI:10.1093/eurheartj/ehz405.
  • 11. Marcus JT, Gan CT, Zwanenburg JJ, et al. Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling. J Am Coll Cardiol 2008;51:750-757.
  • 12. Mauritz GJ, Marcus JT, Westerhof N, Postmus PE, Vonk-Noordegraaf A. Prolonged right ventricular post-systolic isovolumic period in pulmonary arterial hypertension is not a reflection of diastolic dysfunction. Heart 2011;97:473-478.
  • 13. Konstantinides S, Geibel A, Kasper W, Olschewski M, Blumel L, Just H. Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism. Circulation 1998;97:1946-1951.
  • 14. Harjola VP, Mebazaa A, Celutkiene J, et al. Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail 2016;18:226-241.
  • 15. Stein PD, Terrin ML, Hales CA, et al. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest 1991;100:598.
  • 16. Pollack CV, Schreiber D, Goldhaber SZ, et al. Clinical characteristics, management, and outcomes of patients diagnosed with acute pulmonary embolism in the emergency department: initial report of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry. J Am Coll Cardiol 2011;57:700-706.
  • 17. Ammar H, Ohri C, Hajouli S, et al. Prevalence and Predictors of Pulmonary Embolism in Hospitalized Patients with Syncope. South med J 2019;112(8):421-427. DOI:10.14423/SMJ.0000000000001009.
  • 18. Rodger MA, Carrier M, Jones GN, et al. Diagnostic value of arterial blood gas measurement in suspected pulmonary embolism. Am J Respir Crit Care Med 2000;162:2105-2108.Stein PD, Goldhaber SZ, Henry JW. Alveolar-arterial oxygen gradient in the assessment of acute pulmonary embolism. Chest 1995;107:139.
  • 19. Stein PD, Goldhaber SZ, Henry JW. Alveolar-arterial oxygen gradient in the assessment of acute pulmonary embolism. Chest 1995;107:139.
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Toplam 100 adet kaynakça vardır.

Ayrıntılar

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Afşın İpekci 0000-0001-6125-4061

Yayımlanma Tarihi 1 Kasım 2019
Gönderilme Tarihi 28 Ekim 2019
Kabul Tarihi 30 Ekim 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 1 Sayı: 1

Kaynak Göster

Vancouver İpekci A. PULMONER EMBOLİ 2019. Phnx Med J. 2019;1(1):51-63.

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