Effect of Silica-Based Enterosorbent Use on Diarrhea Duration in Children with Rotavirus Gastroenteritis: A Multicenter, Two-Group Comparative Study
Abstract
Objective: This study aimed to evaluate the effect of adding Colloidal Silicon Dioxide to standard outpatient treatment on the clinical course of children aged 2–14 years with rotavirus antigen–positive acute gastroenteritis.
Materials and Methods: A two-group comparative analysis was conducted in rotavirus-positive children managed on an outpatient basis. The treatment groups were standard therapy (oral rehydration + zinc + probiotic) and standard therapy plus Colloidal Silicon Dioxide. A total of 300 children with confirmed rotavirus infection were included across five different hospitals: 150 received standard therapy alone and 150 received additional Colloidal Silicon Dioxide. The study was designed as a multicenter, multisite, two-group comparative study. The follow-up window was Day 0–7. The primary endpoint was time to diarrhea resolution, defined as the first day with stool frequency ≤3/day and a Bristol Stool Scale score ≤5. Secondary endpoints included total stool count, stool type and consistency, fever course, hospital revisits, school and work absenteeism, and product safety. Appropriate parametric or nonparametric tests were used for continuous variables; Fisher’s exact test for categorical variables; and Kaplan–Meier analysis with log-rank testing for diarrhea resolution (p < 0.05).
Results: A total of 300 children (standard therapy n = 150; standard therapy plus Colloidal Silicon Dioxide n = 150) were analyzed. The mean age was 6.6 years in both groups. Median time to diarrhea resolution was 7.0 (6.0–8.0) days in the standard therapy group versus 2.0 (1.0–2.0) days in the Colloidal Silicon Dioxide group (log-rank p < 0.001). By Day 7, diarrhea resolution rates were 60.0% (90/150) in the standard group and 100.0% (150/150) in the Colloidal Silicon Dioxide group. The cumulative stool burden during Days 0–7 was significantly lower in the Colloidal Silicon Dioxide group (p < 0.001). The number of febrile days and the time to the last loose/watery stool were also significantly shorter in the Colloidal Silicon Dioxide group (p < 0.001). Intravenous fluid requirement and revisit rates were lower in the Colloidal Silicon Dioxide group.
Conclusion: In rotavirus-positive children managed on an outpatient basis, the addition of Colloidal Silicon Dioxide to standard therapy reduced symptom burden and healthcare utilization and significantly accelerated clinical recovery.
Ethical Statement
The authors declare no conflict of interest.
Supporting Institution
No financial support was received for this study.
Thanks
Dear Editor, Thank you for your time and consideration in the evaluation of our manuscript. We sincerely appreciate your efforts and believe that your valuable input will contribute to improving the scientific quality of our work. Sincerely,
References
- 1- World Health Organization. Diarrhoeal disease. Geneva: WHO; 2024.
- 2- World Health Organization. Zinc supplementation in the management of diarrhoea. Geneva: WHO; 2023.
- 3- World Health Organization. Rotavirus vaccines: WHO position paper. Wkly Epidemiol Rec. 2021;96:301–319.
- 4- Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: Update 2014. J Pediatr Gastroenterol Nutr. 2014;59(1):132–152. doi:10.1097/MPG.0000000000000375.
- 5- Szajewska H, Dziechciarz P. Gastrointestinal infections in the pediatric population. Curr Opin Gastroenterol. 2010;26(1):36–44.
- 6- Mikhalovsky S, Voytko O. Enterosorption in medicine: principles and clinical applications. Chem J Mold. 2021;16(2):9–27.
- 7- Belokonova LV, Zaytseva LYu, Menshikova SV, Popilov MA, Provotorov VYa, Khmelevskaya IG. Evaluation of the clinical efficiency of modern enterosorbents used for the treatment of rotaviral gastroenteritis in children. J Pediatr Infect Dis. 2017;16:45–52.
- 8- Vershinin AS, Popilov AN. Use of enterosorbent Polisorb MP in pediatric practice. Russ Med Zh. 2008;16(18):1178–1182.
- 9- Szajewska H, Guarino A, Hojsak I, et al. Use of probiotics and other supplements for management of acute
- 10- Dennehy PH. Rotavirus infections: an update on epidemiology and prevention. Pediatr Infect Dis J. 2015;34(3):e38–e44.
- 11- Fatullayeva S, Tagiyev D, Zeynalov N. Enterosorbents in clinical practice: mechanisms and safety. Colloid Interface Sci Commun. 2021;45:100545.
- 12- Freedman SB, Pasichnyk D, Black KJL, et al. Management of acute gastroenteritis in children. N Engl J Med. 2018;379:146–155.
- 13- Walker CLF, Rudan I, Liu L, et al. Global burden of childhood diarrhea and pneumonia. Lancet. 2013;381:1405–1416. 14- Centers for Disease Control and Prevention. Clinical overview of rotavirus infection. CDC; 2025. Available from: https://www.cdc.gov/rotavirus.
- 15- Yılmaz B, Köle T, Karaaslan F, Pişmişoğlu K, Arıca V. Examination of Socio-demographic, Clinical and Laboratory Findings of Patients Hospitalized in Our Clinic with the Diagnosis of Rotavirus Gastroenteritis. Bagcilar Med Bull. 2024; 9(2), 80-86.
- 16- Vefik Arıca, Hanifi Bayaroğulları, Murat Tutanç, Seçil Gunher Arıca, Fatmagül Başarslan, Tayip Mehmet Arslan, Yeliz Beyoğlu. Rotavirüs enteriti nedeniyle yatırılan bir olguda juvenil pilositik astrositom. Duzce Univ J Health Sci Inst. 2011; 1 (3): 31-34.
- 17- Altınkıran E, Kaya G, Gürer Giray B, Köse Kabil N, Uysal D, Ergenç Z, Ergenç H, Arıca V. Evaluation of patients diagnosed with tuberculosis in Yalova, the smallest province in Türkiye and a priority city in migration ranking. J Biotechnol Strateg Health Res. 2024;8(3):257–264.
- 18- Gemici Karaaslan HB, Turkkan E, Goksoy Topal E, Karaaslan F, Dag H, Arica V. Association of depression and social anxiety symptom scores with disease characteristics in pediatric patients with chronic immune thrombocytopenia: a cross-sectional study. Int J Hematol. 2024;120:356–364.
- 19- Dinleyici E, Özen M, Dalgıç N, Yasa O, Arıca V, Vandenplas Y. Effect of Lactobacillus rhamnosus LGG and Bifidobacterium animalis subsp. lactis BB-12 combination on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey. Mucosa. 2020;2(3):34–41.
- 20- Dinleyici EC, Kara A, Dalgıç N, Kurugol Z, Arıca V, Türel Ö, Güven Ş, Yasa O, Özen M, Vandenplas Y. Saccharomyces boulardii CNCM I-745 reduces the duration of diarrhoea, length of emergency care and hospital stay in children with acute diarrhoea. Benef Microbes. 2015;6(4):415–421.
- 21- Dinleyici EC, Dalgic N, Guven S, Metin O, Yasa O, Kurugol Z, et al. Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting. J Pediatr (Rio J). 2015;91(4):392–396.
- 22- Dinleyici EC, Dalgic N, Guven S, Ozen M, Kara A, Arica V, et al. The effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey: a single-blinded randomized study. Eur J Pediatr. 2013;172(4):459–464.
Çocuklarda Rotavirüs Gastroenteritinde Silika Bazlı Enterosorbent Kullanımının Diyare Süresine Etkisi: Çok Merkezli, Multisentrik, İki Grup Karşılaştırmalı Çalışma
Abstract
Amaç: Bu çalışmada, rotavirüs antijen testi pozitif akut gastroenteritli 2–14 yaş çocuklarda ayaktan standart tedaviye Kolloidal Silisyum Dioksit eklenmesinin klinik seyir üzerine etkisini değerlendirmek amaçlandı. Kolloidal Silisyum Dioksit
Gereç ve Yöntem: Rotavirüs pozitif ayaktan izlenen çocuklarda iki gruplu karşılaştırmalı analiz yapıldı (Standart tedavi: sıvı + çinko + probiyotik; Standart+ Kolloidal Silisyum Dioksit. Çalışma toplam 5 ayrı hastanede standart tedavi verilen 150 ve standart tedaviye ek olarak Kolloidal Silisyum Dioksit kullanan 150 Rotavirüs tanılı çocuk dahil edilidi. Çalışmamız çok merkezli, multisentrik ve iki grup karşılaştırmalı olarak planlandı. Çalışma Takip penceresi Gün 0–7 idi. Primer sonlanım ishalin düzelmesine kadar geçen süre olarak tanımlandı (ilk kez dışkı sayısı ≤3/gün ve Bristol ≤5 sağlanması). İkincil sonlanımlar toplam dışkı sayısı, dışkı tipi, dışkı kıvamı, ateş seyri, hastaneye başvuru, okul ve işgücü kaybı ve ürün güvenliği idi. Sürekli değişkenlerde uygun parametrik/parametrik olmayan testler; ikili değişkenlerde Fisher kesin testi; ishal düzelme için Kaplan-Meier ve log-rank testi kullanıldı (p<0,05).
Bulgular: Toplam 300 çocuk (Standart n=150; Standart+ Kolloidal Silisyum Dioksit n=150) analiz edildi. Yaş ortalaması her iki grupta 6,6 yıl idi. İshal düzelme süresi Standart grupta 7,0 (6,0–8,0) gün iken Kolloidal Silisyum Dioksit grubunda 2,0 (1,0–2,0) gün bulundu (log-rank p=<0,001); 7. gün sonunda düzelme oranı sırasıyla %60,0 (90/150) ve %100,0 (150/150) idi. 0–7 gün dışkı yükü Kolloidal Silisyum Dioksit grubunda daha düşüktü (p<0,001). Ateşli gün sayısı ve son lapa/sulu dışkı günü Kolloidal Silisyum Dioksit grubunda anlamlı olarak daha kısa bulundu (p<0,001). İV sıvı ihtiyacı ve tekrar başvuru oranları Kolloidal Silisyum Dioksit grubunda daha düşüktü.
Sonuç: Rotavirüs pozitif ayaktan çocuklarda standart tedaviye Kolloidal Silisyum Dioksit eklenmesi semptom yükünü ve sağlık hizmeti kullanımını azaltmış, klinik iyileşmeyi hızlandırmıştır.
Ethical Statement
Yazarlar herhangi bir çıkar çatışması bildirmemiştir.
Supporting Institution
Bu çalışma için herhangi bir finansal destek alınmamıştır.
Thanks
Sayın Editör, Makalemizin değerlendirilmesi sürecinde ayırdığınız zaman ve gösterdiğiniz ilgi için teşekkür ederiz. Değerli katkılarınızın çalışmamızın bilimsel niteliğini artıracağına inanıyoruz. Saygılarımızla,
References
- 1- World Health Organization. Diarrhoeal disease. Geneva: WHO; 2024.
- 2- World Health Organization. Zinc supplementation in the management of diarrhoea. Geneva: WHO; 2023.
- 3- World Health Organization. Rotavirus vaccines: WHO position paper. Wkly Epidemiol Rec. 2021;96:301–319.
- 4- Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: Update 2014. J Pediatr Gastroenterol Nutr. 2014;59(1):132–152. doi:10.1097/MPG.0000000000000375.
- 5- Szajewska H, Dziechciarz P. Gastrointestinal infections in the pediatric population. Curr Opin Gastroenterol. 2010;26(1):36–44.
- 6- Mikhalovsky S, Voytko O. Enterosorption in medicine: principles and clinical applications. Chem J Mold. 2021;16(2):9–27.
- 7- Belokonova LV, Zaytseva LYu, Menshikova SV, Popilov MA, Provotorov VYa, Khmelevskaya IG. Evaluation of the clinical efficiency of modern enterosorbents used for the treatment of rotaviral gastroenteritis in children. J Pediatr Infect Dis. 2017;16:45–52.
- 8- Vershinin AS, Popilov AN. Use of enterosorbent Polisorb MP in pediatric practice. Russ Med Zh. 2008;16(18):1178–1182.
- 9- Szajewska H, Guarino A, Hojsak I, et al. Use of probiotics and other supplements for management of acute
- 10- Dennehy PH. Rotavirus infections: an update on epidemiology and prevention. Pediatr Infect Dis J. 2015;34(3):e38–e44.
- 11- Fatullayeva S, Tagiyev D, Zeynalov N. Enterosorbents in clinical practice: mechanisms and safety. Colloid Interface Sci Commun. 2021;45:100545.
- 12- Freedman SB, Pasichnyk D, Black KJL, et al. Management of acute gastroenteritis in children. N Engl J Med. 2018;379:146–155.
- 13- Walker CLF, Rudan I, Liu L, et al. Global burden of childhood diarrhea and pneumonia. Lancet. 2013;381:1405–1416. 14- Centers for Disease Control and Prevention. Clinical overview of rotavirus infection. CDC; 2025. Available from: https://www.cdc.gov/rotavirus.
- 15- Yılmaz B, Köle T, Karaaslan F, Pişmişoğlu K, Arıca V. Examination of Socio-demographic, Clinical and Laboratory Findings of Patients Hospitalized in Our Clinic with the Diagnosis of Rotavirus Gastroenteritis. Bagcilar Med Bull. 2024; 9(2), 80-86.
- 16- Vefik Arıca, Hanifi Bayaroğulları, Murat Tutanç, Seçil Gunher Arıca, Fatmagül Başarslan, Tayip Mehmet Arslan, Yeliz Beyoğlu. Rotavirüs enteriti nedeniyle yatırılan bir olguda juvenil pilositik astrositom. Duzce Univ J Health Sci Inst. 2011; 1 (3): 31-34.
- 17- Altınkıran E, Kaya G, Gürer Giray B, Köse Kabil N, Uysal D, Ergenç Z, Ergenç H, Arıca V. Evaluation of patients diagnosed with tuberculosis in Yalova, the smallest province in Türkiye and a priority city in migration ranking. J Biotechnol Strateg Health Res. 2024;8(3):257–264.
- 18- Gemici Karaaslan HB, Turkkan E, Goksoy Topal E, Karaaslan F, Dag H, Arica V. Association of depression and social anxiety symptom scores with disease characteristics in pediatric patients with chronic immune thrombocytopenia: a cross-sectional study. Int J Hematol. 2024;120:356–364.
- 19- Dinleyici E, Özen M, Dalgıç N, Yasa O, Arıca V, Vandenplas Y. Effect of Lactobacillus rhamnosus LGG and Bifidobacterium animalis subsp. lactis BB-12 combination on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey. Mucosa. 2020;2(3):34–41.
- 20- Dinleyici EC, Kara A, Dalgıç N, Kurugol Z, Arıca V, Türel Ö, Güven Ş, Yasa O, Özen M, Vandenplas Y. Saccharomyces boulardii CNCM I-745 reduces the duration of diarrhoea, length of emergency care and hospital stay in children with acute diarrhoea. Benef Microbes. 2015;6(4):415–421.
- 21- Dinleyici EC, Dalgic N, Guven S, Metin O, Yasa O, Kurugol Z, et al. Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting. J Pediatr (Rio J). 2015;91(4):392–396.
- 22- Dinleyici EC, Dalgic N, Guven S, Ozen M, Kara A, Arica V, et al. The effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey: a single-blinded randomized study. Eur J Pediatr. 2013;172(4):459–464.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Pediatric Infectious Diseases |
| Journal Section | Research Article |
| Authors | |
| Submission Date | January 15, 2026 |
| Acceptance Date | February 16, 2026 |
| Publication Date | February 20, 2026 |
| DOI | https://doi.org/10.21765/pprjournal.1863063 |
| IZ | https://izlik.org/JA56KJ44WK |
| Published in Issue | Year 2026 Volume: 14 Issue: 1 |
Cite
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Teke Z, Kabay B, Aytekin FO et al. Pyrrolidine dithiocarbamate prevents 60 minutes of warm mesenteric ischemia/reperfusion injury in rats. Am J Surg 2007;194(6):255-62. Supplement Online article not yet published in an issue
Butterly SJ, Pillans P, Horn B, Miles R, Sturtevant J. Off-label use of rituximab in a tertiary Queensland hospital. Intern Med J doi: 10.1111/j.1445-5994.2009.01988.x Book Sample 2: Sümbüloğlu K, Akdağ B. Regresyon Yöntemleri ve Korelasyon Analizi. Hatiboğlu Yayınevi: Ankara; 2007. Chapter in a book
Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. I n: Vogelstein B, Kinzler KW, editors. The genetic basis of human cancer. New York: McGraw-Hill; 2002. p. 93113. Journal article on the Internet
Abood S. Quality improvement initiative in nursing homes: The ANA acts in an advisory role. Am J Nurs [serial on the Internet] 2002 [cited 12 Aug 2002]; 102. Available from: www.nursingworld.org/AJN/2002/june/wawatch.htm Website An organization as an author
The Intensive Care Society of Australia and New Zealand. Mechanical ventilation strategy in ARDS: Guidelines. Int Care J Aust 1996;164:282-4. Acknowledgements Tables
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Pediatric Practice and Research
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The publication process at Pediatric Practice and Research Journal is the basis of the improvement and dissemination of information objectively and respectfully. Therefore, the procedures in this process improves the quality of the studies. Peer-reviewed studies are the ones that support and materialize the scientific method. At this point, it is of utmost importance that all parties included in the publication process (authors, readers and researchers, publisher, reviewers and editors) comply with the standards of ethical considerations. Pediatric Practice and Research Journal expects all parties to hold the following ethical responsibilities.
The journal's publication processes are executed in accordance with the guides, International Medical Journals Editors Board (ICMJE), World Association of Medical Editors (WAME), Council of Science Editors (CSE), Committee on Publication Ethics (COPE), European Association of Science Editors (EASE) ,National Information Standards Organization (NISO) and DOAJ-Principles of Transparency and Best Practice in Scholarly Publishing
International Medical Journals Editors Board (ICMJE),
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Council of Science Editors (CSE),
Committee on Publication Ethics (COPE),
European Association of Science Editors (EASE),
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DOAJ-Principles of Transparency and Best Practice in Scholarly Publishing
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The relationship between the editors and publisher is based on the principle of the independency of editors. All the decisions made by the editors are independent of the publisher and the owner of the journal as required by the agreement made between editors and publisher.
Editorial and Blind Review Processes
Editors are obliged to comply with the policies of "Blind Review and Review Process" stated in the journal's publication policies. Therefore, the editors ensure that each manuscript is reviewed in an unbiased, fair and timely manner.
Quality Assurance
Editors must make sure that articles in the journal are published in accordance with the publication policies of the journal and international standards.
Protection of Personal Information
Editors are supposed to protect the personal information related with the subjects or visuals in the studies being reviewed, and to reject the study if there is no documentation of the subjects' consent. Furthermore, editors are supposed to protect the personal information of the authors, reviewers and readers.
Encouraging Ethical Rules and Protection of Human and Animal Rights
Editors are supposed to protect human and animal rights in the studies being reviewed and must reject the experimental studies which do not have ethical and related committee’s approval about the population given in such studies.
Precautions against possible Abuse and Malpractice
Editors are supposed to take precautions against possible abuse and malpractice. They must conduct investigations meticulously and objectively in determining and evaluating complaints about such situations. They must also share the results of the investigation.
Ensuring Academic Integrity
Editors must make sure that the mistakes, inconsistencies or misdirections in studies are corrected quickly.
Protection of Intellectual Property Rights
Editors are responsible for protecting the intellectual property rights of all the articles published in the journal and the rights of the journal and author(s) in cases where these rights are violated. Also, editors must take the necessary precautions in order to prevent the content of all published articles from violating the intellectual property rights of other publications.
Constructiveness and Openness to Discussion
Editors must
• Pay attention to the convincing criticism about studies published in the journal and must have a constructive attitude towards such criticism.
• Grant the right of reply to the author(s) of the criticized study.
• Not ignore or exclude the study that include negative results.
Complaints
Editors must examine the complaints from authors, reviewers or readers and respond to them in an explanatory and enlightening manner.
Political and Economic Apprehensions
Neither the owner of the journal, publisher or any other political or economical factor can influence the independent decision taking of the editors.
Conflicting Interests
Editors, acknowledging that there may be conflicting interests between reviewers and other editors, guarantee that the publication process of the manuscripts will be completed in an independent and unbiased manner
Ethical Responsibilities of Reviewers
The fact that all manuscripts are reviewed through "Blind Review" has a direct influence on the publication quality. This process ensures confidentiality by objective and independent review. The review process at J Contemp Med is carried out on the principle of double blind review. Reviewers do not contact the authors directly, and the reviews and comments are conveyed through the journal management system. In this process, the reviewer views on the evaluation forms and full texts are assigned to the author(s) by the editor. Therefore, the reviewers doing review work for J Contemp Med are supposed to bear the following ethical responsibilities:
Reviewers must
• Agree to review only in their subject of expertise.
• Review in an unbiased and confidential manner.
• Inform the editor of the journal if they think that they encounter conflict of interests and decline to review the manuscript during the review process.
• Dispose the manuscripts they have reviewed in accordance with the principle of confidentiality after the review process. Reviewers can use the final versions of the manuscripts they have reviewed only after publication.
• Review the manuscript objectively and only in terms of its content and ensure that nationality, gender, religious and political beliefs, and economic apprehension do not influence the review.
• Review the manuscript in a constructive and kind tone, avoid making personal comments including hostility, slander and insult.
• Review the manuscript they have agreed to review on time and in accordance with the ethical rules stated above.
Ethical Responsibilities of Publisher
Publisher of Pediatric Practice and Research Journal
• The Editors and the Editorial Board of PPR Journal are conscious of the fact that they must observe the ethical responsibilities below and act accordingly:
• Editors are responsible for all the processes that the manuscripts submitted to Pediatric Practice and Research Journal will go through. Within this framework, ignoring the economic or political interests, the decision-makers are the editors.
• The publisher undertakes to have an independent editorial decision made.
• The publisher protects the intellectual property rights of all the articles published in J Contemp Med and holds the responsibility to keep a record of each unpublished article.
• The publisher bears all the responsibility to take the precautions against scientific abuse, fraud and plagiarism.
Unethical Behaviour
Should you encounter any unethical act or content in J Contemp Med apart from the ethical responsibilities listed above, please notify the journal by e-mail at cagdastipdergisi@gmail.com.
Briefly:
Authorship Criteria
After accepted for publication, all the authors will be asked to sign “Copyright Transfer Form” which states the following: “ This work is not under active consideration for publication, has not been accepted for publication, nor has it been published, in full or in part (except in abstract form). I confirm that the study has been approved by the ethics committee. ” All authors should agree to the conditions outlined in the form.
Pediatric Practice and Research Journal has agreed to use the standards of the International Committee of Medical Journal Editors. The author(s) should meet the criteria for authorship according to the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publication. It is available at www.icmje.org.
Ethical Responsibility Ethical Responsibility / Rules:
The protocol of clinical research articles must be approved by the Ethics Committee.
In all studies conducted on humans, the “Material and Method” section was approved by the relevant committee or the Helsinki Declaration of Principles (https://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/).
It should be stated in the text that all persons included in the study signed the am Informed Consent Form ”.
The articles submitted to the Pediatric Practice and Research Journal will be deemed to have been conducted in accordance with the Helsinki Declaration of Principles, and have received ethical and legal permissions and will not be held responsible.
If the “Animal” item was used in the study, the authors stated that in the Material and Method section of the article, they protect the animal rights in their studies in accordance with the principles of Guide for the Care and Use of Laboratory Animals (https://grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals.pdf) and that they have received approval from the ethics committees of their institutions. must specify.
In case reports, Informed Consent a should be obtained from patients regardless of the identity of the patient.
If the article includes the institution (directly or indirectly) providing financial support for the commercial connection or work, the authors; the commercial product used, the drug, the company has no commercial relationship with, or if there is any relationship (consultant, other agreements, etc.), the editor must inform the presentation page.
If Ethics Committee Approval is required in the article; the received document should be sent with the article.
The manuscript should be submitted to the Academic Plagiarism Prevention Program by the authors.
It is the authors' responsibility to ensure that the article complies with the ethical rules
Policy of Screening for Plagiarism
The manuscripts are scanned by the Journal using the iThenticate program for determination of plagiarism and non-ethical situations. Pediatric Practice and Research Journal will immediately reject manuscripts leading to plagiarism
Price Policy
free of charge
