Bibliometric Analysis of New Inhibitors Targeting Extended Spectrum Beta-Lactamase Enzymes

Öz

Bacterial resistance to available antibiotics has increasingly become a critical issue, necessitating the search for novel inhibitors to combat resistant pathogens, particularly gram-negative bacteria. This bibliometric study aims to analyze the scientific literature on novel inhibitors for extended spectrum beta-lactamase (ESBL) enzymes, identifying the most prolific organizations, authors, journals, countries, and keywords within this research area. Data were retrieved from Dimensions and Scopus databases, with 503 out of 2086 papers (published between 2013 and 2023) meeting the inclusion criteria. Analysis and visualization were performed using R-studio software and VOSviewer©, focusing on article titles, publication years, countries, authors, journals, and keywords. The study found that the United States led in the number of publications (445) and citations (15.889), followed by France and China. The journal Antimicrobial Agents and Chemotherapy published the most articles (171) and received the highest citations. Indiana University Bloomington and Case Western Reserve University from the U.S. were the leading institutions. Robert Bonomo authored the most papers (23), while Karen Bush was the highest-cited author (1.955 citations). Key future research hotspots include "taniborbactam," "xeruborbactam," "enmetazobactam," "VNRX-5236," and "imipenem-relebactam." This study underscores the critical global efforts and contributions in developing novel inhibitors against ESBL enzymes. The findings highlight key authors, influential journals, and emerging research directions that can guide future studies in combating antibiotic resistance among gram-negative bacteria.

Anahtar Kelimeler

• Bacterial Resistance
• Bibliometric Analysis
• Extended Spectrum Beta-Lactamase
• Inhibitors
• Vosviewer

Genişletilmiş Spektrumlu Beta-Laktamaz Enzimlerini Hedefleyen Yeni İnhibitörlerin Bibliyometrik Analizi

Öz

Mevcut antibiyotiklere karşı bakteriyel direnç, özellikle gram-negatif bakterilerde dirençli patojenlerle mücadele için yeni inhibitörlerin bulunmasını zorunlu hale getirmiştir. Bu bibliyometrik çalışmanın amacı, genişletilmiş spektrumlu beta-laktamaz (GSBL) enzimlerine karşı geliştirilen yeni inhibitörler konusundaki bilimsel literatürü analiz etmek, bu araştırma alanındaki en üretken kuruluşları, yazarları, dergileri, ülkeleri ve anahtar kelimeleri belirlemektir. Veriler, 2013-2023 yılları arasında yayımlanan 2086 makaleden 503'ünün dahil edilme kriterlerini karşılayarak Dimensions ve Scopus veritabanlarından alınmıştır. Analiz ve görselleştirme süreçleri, makale başlıkları, yayımlanma yılları, ülkeler, yazarlar, dergiler ve anahtar kelimelere odaklanarak R-studio yazılımı ve VOSviewer© kullanılarak gerçekleştirilmiştir. Çalışma, yayın sayısı (445) ve atıf sayısı (15,889) bakımından Amerika Birleşik Devletleri'nin ilk sırada olduğunu, bunu Fransa ve Çin'in izlediğini ortaya koymuştur. Antimicrobial Agents and Chemotherapy dergisi, en fazla makale (171) yayımlayan ve en yüksek atıf alan dergi olmuştur. Amerika Birleşik Devletleri'nden Indiana University Bloomington ve Case Western Reserve University en önde gelen kurumlar olmuştur. Bonomo Robert en fazla makale (23) yazan kişi iken, Bush Karen en çok atıf (1,955) alan yazardır. Gelecekteki önemli araştırma alanları arasında "taniborbactam," "xeruborbactam," "enmetazobactam," "VNRX-5236" ve "imipenem-relebactam" yer almaktadır. Bu çalışma, GSBL enzimlerine karşı geliştirilen yenilikçi inhibitörler konusunda küresel araştırmaların önemini ve katkılarını vurgulamaktadır. Bulgular, gram-negatif bakterilerde antibiyotik direnciyle mücadelede gelecekteki çalışmalara rehberlik edebilecek önemli yazarları, etkili dergileri ve yükselen araştırma yönlerini vurgulamaktadır.

Anahtar Kelimeler

• Bakteriyel Direnç
• Bibliyometrik Analiz
• Genişletilmiş Spektrumlu Beta-Laktamaz
• İnhibitörler
• Vosviewer

Kaynakça

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