Measurement of the Penetration Depth in Biological Tissue for Different Optical Powers

Abstract

In photodynamic therapy, the knowledge of the penetration depth for the light is needed in order to ensure that the optical energy received by the tumorous tissue. In this study, the optical penetration depths of 635 nm laser light in chicken breast tissue have been measured by using 8 tissue samples with different thicknesses between 2.5 mm and 9.0 mm. Transmitted light intensities through the tissue samples have been measured with 11 different optical power values in the range of 130mW – 660mW. Measurement results for each power value have been analyzed according to the Beer-Lambert law. With the help of statistical analyzes, it has been determined that the optical penetration depth of the light in biological tissue does not depend on its optical power.

Keywords

• PDT,Penetration depth,Beer-Lambert law

Biyolojik Dokulardaki Penetrasyon Derinliklerinin Farklı Optik Güç Değerleri İçin Ölçülmesi

Abstract

Fotodinamik Terapi’de (PDT), tümörlü doku tarafından alınan optik enerjinin yeterli olup olmadığının belirlenebilmesi için ışığın doku içindeki penetrasyon derinliğinin bilinmesi gereklidir. Bu çalışmada, 635 nm lazer ışığının tavuk göğsü dokusundaki penetrasyon derinliği 2.5 mm ile 9.0 mm arasında değişen farklı kalınlıklarda 8 doku örneği kullanılarak ölçülmüştür. Doku örneklerinde iletilen ışık yoğunlukları 130mW – 660mW aralığındaki 11 farklı optik güç değeri için ölçülmüştür. Her bir güç değeri için ölçüm sonuçları Beer-Lambert yasasına göre analiz edilmiştir. İstatistiksel analizler yardımıyla, biyolojik dokudaki penetrasyon derinliğinin optiksel güce bağlı olmadığı saptanmıştır.

Keywords

• FDT,Penetrasyon derinliği,Beer-Lambert Yasası

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