Anti-kanser ilacı imatinib’in elektro-oksidasyon prosesi ile gideriminin yüzey yanıt metodu kullanılarak incelenmesi

Abstract

 

Atıksularında bulunan farmasötikler sucul canlılar üzerinde oldukça toksik olmaları nedeniyle büyüyen bir endişe haline gelmektedir. Atıksularda ve yüzeysel sularda farmasötiklerin konsantrasyonları µg/L ve ng/L gibi çok düşük seviyelerde olmasına rağmen bunların kronik etkileri nedeniyle ciddi ve acil bir araştırmaya gerek duyulmaktadır. Bu çevre ve sağlık problemlerinine yol açan farmasötik mikrokirleticileri atıksulardan gidermek için klasik arıtma yöntemleri yetersiz olması sebebiyle ileri arıtma yöntemlerine ihtiyac duyulmaktadır. Özellikle elektrokimyasal prosesler bu tür mikrokirleticileri arıtmak için oldukça başarılı yöntemler olarak dikkat çekmektedir. Bu çalışmada, Imatinib (IMT) adlı etken maddenin elektro-oksidasyon yöntemi ile arıtılması çalışılmıştır. Imatinib etken maddesinin arıtılması için kimyasal-elektrokimyasal stabiliteye sahip Ti/RuO₂ elektrotu kullanılmıştır. Optimum çalışma şartlarının belirlenmesi amacıyla yüzey yanıt metodu (YYM) kullanılarak proses optimizasyonu yapılmıştır. 

Keywords

• Imatinib,yüzey yanıt,elektro-oksidasyon

Evaluation of anti-cancer drug ımatinib removal by electro-oxidation process using response surface method

Abstract

The pharmaceuticals which are found in the wastewater treatment effluents of the companies that produce cancer drug have become a serious fear for biotic living beings as they are toxic. Although the concentration of pharmaceuticals in surface water and wastewater are in low levels like µg/L and ng/L levels, because of their chronical effects they are needed to be removed from water immediately. They are not amenable to conventional biological treatment due to their toxicity even at low concentrations. Therefore, powerful oxidation methods have to be researched to remove them from waters, thus avoiding their potential adverse health effects on humans and animals. Especially electrochemical processes to purify such micro pollutants have attracted attention as very successful methods. In this study, electro-oxidation of Imatinib (IMT) has been studied. Ti/RuO₂ electrode which has chemical and elevtrochenical stability has been used. In order to determine their operation conditions, process optimization has been done by using Response Surface Method (RSM). 

Keywords

• Imatinib,response surface,electro-oxidation

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