Anti-kanser ilacı imatinib’in elektro-oksidasyon prosesi ile gideriminin yüzey yanıt metodu kullanılarak incelenmesi

Yıl 2018, , 728 - 734, 01.04.2018

Özge Türkay Sibel Barışçı Anatoli Dimoglo

https://doi.org/10.16984/saufenbilder.336449

Öz

 

Atıksularında bulunan farmasötikler
sucul canlılar üzerinde oldukça toksik olmaları nedeniyle büyüyen bir endişe
haline gelmektedir. Atıksularda ve yüzeysel sularda farmasötiklerin
konsantrasyonları µg/L ve ng/L gibi çok düşük seviyelerde olmasına rağmen
bunların kronik etkileri nedeniyle ciddi ve acil bir araştırmaya gerek
duyulmaktadır. Bu çevre ve sağlık problemlerinine yol açan farmasötik mikrokirleticileri
atıksulardan gidermek için klasik arıtma yöntemleri yetersiz olması sebebiyle
ileri arıtma yöntemlerine ihtiyac duyulmaktadır. Özellikle elektrokimyasal
prosesler bu tür mikrokirleticileri arıtmak için oldukça başarılı yöntemler
olarak dikkat çekmektedir. Bu çalışmada, Imatinib (IMT) adlı etken maddenin
elektro-oksidasyon yöntemi ile arıtılması çalışılmıştır. Imatinib etken
maddesinin arıtılması için kimyasal-elektrokimyasal stabiliteye sahip Ti/RuO₂
elektrotu kullanılmıştır. Optimum çalışma şartlarının belirlenmesi amacıyla
yüzey yanıt metodu (YYM) kullanılarak proses optimizasyonu yapılmıştır. 

Anahtar Kelimeler

Imatinib, yüzey yanıt, elektro-oksidasyon

Evaluation of anti-cancer drug ımatinib removal by electro-oxidation process using response surface method

Öz

The pharmaceuticals which are found in the wastewater
treatment effluents of the companies that produce cancer drug have become a
serious fear for biotic living beings as they are toxic. Although the
concentration of pharmaceuticals in surface water and wastewater are in low
levels like µg/L and ng/L levels, because of their chronical effects they are
needed to be removed from water immediately. They are not amenable to
conventional biological treatment due to their toxicity even at low
concentrations. Therefore, powerful oxidation methods have to be researched to
remove them from waters, thus avoiding their potential adverse health effects
on humans and animals. Especially electrochemical processes to purify such
micro pollutants have attracted attention as very successful methods. In this
study, electro-oxidation of Imatinib (IMT) has been studied. Ti/RuO₂
electrode which has chemical and elevtrochenical stability has been used. In
order to determine their operation conditions, process optimization has been
done by using Response Surface Method (RSM). 

Anahtar Kelimeler

Imatinib, response surface, electro-oxidation

Kaynakça

• S. Nussbaumer, P. Bonnabry, J. L. Veuthey, S. Felury-Souverain, “Analysis of anticancer drugs: a review,” Talanta, vol. 85, pp. 2265–2289, 2011.
• S. Santana-Viera, S. Montesdeoca-Esponda, Z. Sosa-Ferrera, J. J. Santana-Rodríguez, “Cytostatic drugs in environmental samples: An update on the extraction and determination procedures,” Trends in Analytical Chemistry, vol. 80, pp. 373–386, 2016.
• M. Isodori, M. Lavorgna, C. Russo, M. Kundi, B. Zegura, M. Novak, M. Filipic, M. Misik, S. Knasmueller, M. L. de Alda, D. Barcelo, B. Zonja, M. Cesen, J. Sacncar, T. Kosjek, “Chemical and toxicological characterisation of anticancer drugs in hospital and municipal wastewaters from Slovenia and Spain,” Environmental Pollution, vol. 219, pp. 275–287, 2016.
• S. Mompelat, B. LeBot, O. Thomas, “Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water,” Environment International, vol. 35, pp. 803–814, 2009.
• R. Andreozzi, V. Caprio, C. Ciniglia, M. de Champdoré, R. Lo Giudice, R. Marotta, E. Zuccato, “Antibiotics in the environment: occurrence in Italian STPs, fate, and preliminary assessment on algal toxicity of amoxicillin.,” Environmental Science and Technology, vol. 38, pp. 6832–6838, 2004.
• B. Du, A. E. Price, W. C. Scott, L. A. Kristofco, A. J. Ramirez, C. K. Chambliss, J. C. Yelderman, B. W. Brooks, “Comparison of contaminants of emerging concern removal, discharge, and water quality hazards among centralized and on-site wastewater treatment system effluents receiving common wastewater influent,” Science of the Total environment, vol. 85, pp. 976–984, 2014.
• F. Sopaj, M. A. Rodrigo, N. Oturan, F. I. Podvorica, J. Pinson, M. A. Oturan, “Influence of the anode materials on the electrochemical oxidation efficiency. Application to oxidative degradation of the pharmaceutical amoxicillin,” Chemical Engineering Journal, vol. 262, pp. 286–294, 2015.
• J. Wu, H. Zhang, N. Oturan, Y. Wang, L. Chen, M. A. Oturan, “Application of response surface methodology to the removal of the antibiotic tetracycline by electrochemical process using carbon-felt cathode and DSA (Ti/RuO2–IrO2) anode,” Talanta, vol. 85, pp. 2265–2289, 2011.
• E. Guinea, C. Arias, P. L. Cabot, J. A. Garrido, F. Centellas, E. Brillas, “Mineralization of salicylic acid in acidic aqueous medium by electrochemical advanced oxidation processes using platinum and boron-doped diamond as anode and cathodically generated hydrogen peroxide,” Water Research, vol. 42, pp. 499-511, 2008.