Yeni rutenyum-azol komplekslerinin sentezi ve antioksidan özellikleri

Abstract

Bu çalışmada, iki yeni dikloro-(1-alkilimidazolin)-(p-simen)rutenyum(II), 3 ve dikloro-(1-alkilbenzimidazol)-(p-simen)rutenyum(II), 4 kompleksi sentezlendi ve yapıları spektroskopik tekniklerle karakterize edildi. Bu yeni metal komplekslerin in vitro antioksidan aktiviteleri; 2,2-difenil-1-pikrilhidrazil (DPPH), hidroksil (^•OH) ve süperoksit  (O₂^-.) radikallerini inhibe etme özellikleri ile araştırıldı. Ayrıca her bir metal kompleksinin toplam antioksidan aktivitesi de saptandı. 3 Numaralı kompleksin DPPH, hidroksil ve süperoksit radikallerini süpürme aktivitelerinin ve toplam antioksidan aktivitesinin 4 numaralı kompleksten daha etkili olduğu bulundu.

Keywords

• İmidazolin; Benzimidazol; Rutenyum; DPPH; Hidroksil radikali; Süperoksit radikali; Antioksidan Aktivite

Synthesis of novel ruthenium-azole complexes and antioxidant properties

Abstract

In this study, two novel dichloro-(1-alkylimidazoline)-(p-cymene)ruthenium(II), 3 and dichloro-(1-alkylbenzimidazole)-(p-cymene)ruthenium(II), 4 complexes have been synthesized and characterized by spectroscopic techniques. In vitro antioxidant activities of new metal complexes have been investigated by inhibition properties of 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (^•OH) and superoxide (O₂^-.) radicals. Additionally, total antioxidant activity of each metal complexes was also determined. It was found that total antioxidant activity and DPPH, hydroxyl and superoxide radicals scavenging activities of compound 3 are more efficient than compound 4.

 

 

Keywords

• Imidazoline; Benzimidazole; Ruthenium; DPPH; Hydroxyl Radical; Superoxide Radical; Antioxidant Activity

References

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