Preparation of Hybrid Films Containing Chitosan, Starch, Ascorbic Acid, and Different Metal Ions for Release of Doxorubicin

Yıl 2024, Cilt: 28 Sayı: 3, 594 - 601, 30.06.2024

Ümran Duru Kamacı

https://doi.org/10.16984/saufenbilder.1395859

Öz

As known, composite films containing different metal ions provide improvement in the properties of drug release systems. In this study, it was aimed to prepare composite films containing different metal ions for DOX release, and the effect of metal ions on drug release, swelling, and thermal properties were investigated. The structural characterization of the composite films was carried out using FT-IR, SEM, and TG analysis techniques. SEM images showed that the metal-free film was composed of a homogeneous structure while the calcium composite films consisted of a non-homogenous surface. Also, thermal analysis results showed that the thermal stability increased with the addition of metal ions to the composite film matrix. The swelling and drug-release behavior of the composite films were also studied, and metal ions-containing films exhibited a higher swelling performance and drug-release behavior than the metal-free composite.

Anahtar Kelimeler

Drug release, Composite, Biofilm, Biopolymer

Kaynakça

• [1] G. A. Martau, M. Mihai, D. C. Vodnar, “The use of chitosan, alginate, and pectin in the biomedical and food sector—biocompatibility, bioadhesiveness, and biodegradability”, Polymers vol. 11, pp. 1837, 2019.
• [2] E. B. Yahya, F. Jummaat, A. A. Amirul, A. S. Adnan, N. G. Olaiya, C. K. Abdullah, S. Rizal, M. K. M. Haafiz, H. P. S. A. Khalil, “A review on revolutionary natural biopolymer-based aerogels for antibacterial delivery”, Antibiotics, vol. 9, pp. 648, 2020.
• [3] W. Zhu, D. Zhang, X. Liu, T. Ma, J. He, Q. Dong, Z. Din, J. Zhou, L. Chen, Z. Hu, J. Cai, “Improving the hydrophobicity and mechanical properties of starch nanofibrous films by electrospinning and cross-linking for food packaging applications”, LWT- Food Science and Technology, vol. 169, pp. 114005, 2022.
• [4] L. Wu, S. Lv, D. Wei, S. Zhang, S. Zhang, Z. Li, L. Liu, T. He, “Structure and properties of starch/chitosan food packaging film containing ultra-low dosage GO with barrier and antibacterial”, Food Hydrocolloids, vol. 137, pp. 108329, 2023.
• [5] L. Tuovinen, S. Peltonen, K. Jarvinen, “Drug release from starch-acetate films”, Journal of Controlled Release, vol. 91, pp. 345–354, 2003.
• [6] A. Guo, X. Tao, H. Kong, X. Zhou, H. Wang, J. Li, F. Li, Y. Hu, “Effects of aluminum hydroxide on mechanical, water resistance, and thermal properties of starch-based fiber-reinforced composites with foam structures”, Journal of Materials Research and Technology, vol. 23, pp. 1570-1583, 2023.
• [7] Y. Cao, J. Yin, Y. Shi, J. Cheng, Y. Fang, C. Huang, W. Yu, M. Liu, Z. Yang, H. Zhou, H. Liu, J. Wang, G. Zhao, “Starch and chitosan-based antibacterial dressing for infected wound treatment via self-activated NO release strategy”, International Journal of Biological Macromolecules, vol. 220, pp. 1177–1187, 2022.
• [8] O. M. Khubiev, A. R. Egorov, A. A. Kirichuk, V. N. Khrustalev, A. G. Tskhovrebov, A. S. Kritchenkov, “Chitosan-based antibacterial films for biomedical and food applications”, International Journal of Molecular Sciences, vol. 24, pp. 10738, 2023.
• [9] Z. Jiang, J. Wang, D. Xiang, Z. Zhang, “Functional properties and preservative effect of p-hydroxybenzoic acid grafted chitosan films on fresh-cut jackfruit”, Foods, vol. 11, pp. 1360, 2022.
• [10] S. S. Vedula, G. D. Yadav, “Chitosan-based membranes preparation and applications: Challenges and opportunities”, Journal of the Indian Chemical Society, vol. 98, pp. 100017, 2021.
• [11] D. Radha, J. S. Lal, K. S. Devaky, “Chitosan-based films in drug delivery applications”, Starch, vol. 74, pp. 2100237, 2022.
• [12] P. S. Bakshi, D. Selvakumar, K. Kadirvelu, N. S. Kumar, “Chitosan as an environment friendly biomaterial – a review on recent modifications and applications”, International Journal of Biological Macromolecules, vol. 150, pp. 1072–1083, 2020. [13] A. A. Abd-Elghany, E. A. Mohamad, M. A. El-Sakhawy, S. Mansouri, S. H. Ismail, M. S. Elneklawi, “Enhancement of mechanical properties of chitosan film by doping with sage extract-loaded niosomes”, Materials Research Express, vol. 9, pp. 035006, 2022.
• [14] G. Janarthanan, I. Noh, “Recent trends in metal ion based hydrogel biomaterials for tissue engineering and other biomedical applications”, Journal of Materials Science and Technology, vol. 63, pp. 3553, 2021.
• [15] I. K. Sani, S. Pirsa, S. Tag, “Preparation of chitosan/zinc oxide/Melissa officinalis essential oil nanocomposite film and evaluation of physical, mechanical and antimicrobial properties by response surface method”, Polymer Testing, vol. 79, pp. 106004, 2019.
• [16] S. Li, J. Yi, X. Yu, Z. Wang, L. Wang, “Preparation and characterization of pullulan derivative/chitosan composite film for potential antimicrobial applications”, International Journal of Biological Macromolecules, vol. 148, pp. 258–264, 2020.
• [17] S. Ediyilyam, B. George, S. S. Shankar, T. T. Dennis, S. Waclawek, M. Cernik, V. V. T. Padil, “Chitosan/gelatin/silver nanoparticles composites films for biodegradable food packaging applications”, Polymers, vol. 13, pp. 1680, 2021.
• [18] U. Duru Kamaci, M. Kamaci, “Preparation of polyvinyl alcohol, chitosan and polyurethane-based pH-sensitive and biodegradable hydrogels for controlled drug release applications”, International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 69, pp. 1167–1177, 2020.
• [19] M. Kciuk, A. Gielecinska, S. Mujwar, D. Kolat, Z. K. Kolat, I. Celik, R. Kontek, “Doxorubicin—an agent with multiple mechanisms of anticancer activity”, Cells, vol. 12, pp. 659, 2023.
• [20] R. Sawpari, S. Samanta, J. Banerjee, S. Das, S. S. Dash, R. Ahmed, B. Giri, S. K. Dash, “Recent advances and futuristic potentials of nano-tailored doxorubicin for prostate cancer therapy”, Journal of Drug Delivery Science and Technology, vol. 81, pp. 104212, 2023. [21] S. Karimi, H. Rasuli, R. Mohammadi, “Facile preparation of pH-sensitive biocompatible alginate beads havening layered double hydroxide supported metal-organic framework for controlled release from doxorubicin to breast cancer cells”, International Journal of Biological Macromolecules, vol. 234, pp. 123538, 2023.
• [22] M. Kamaci, “Polyurethane-based hydrogels for controlled drug delivery applications”, European Polymer Journal, vol. 123, pp. 109444, 2020.
• [23] F. J. Warren, M. J. Gidley, B. M. Flanagan, “Infrared spectroscopy as a tool to characterise starch ordered structure—a joint FTIR–ATR, NMR, XRD and DSC study”, Carbohydrate Polymers, vol. 139, pp. 35–42, 2016.
• [24] H. Zhou, D. Zhang, “Effect of graphene oxide aerogel on dehydration temperature of graphene oxide aerogel stabilized MgCl2⋅6H2O composites”, Solar Energy, vol. 184, pp. 202–208, 2019. [25] A. Umer, S. Naveed, N. Ramzan, M. S. Rafique, M. Imran, “A green method for the synthesis of copper nanoparticles using L-ascorbic acid”, Revista Materia, vol. 19, pp. 197-203, 2014.
• [26] L. Balau, G. Lisa, M. I. Popa, V. Tura, V. Melnig, “Physico–chemical properties of chitosan films”, Central European Journal of Chemistry, vol. 2, pp. 638–647, 2004.
• [27] F. Doustdar, A. Olad, Marjan Ghorbani, “Effect of glutaraldehyde and calcium chloride as different crosslinking agents on the characteristics of chitosan/cellulose nanocrystals scaffold”, International Journal of Biological Macromolecules, vol. 208, pp. 912-924, 2022. [28] F. Niazvand, A. Cheshmi, M. Zand, R. N. Azadani, B. Kumari, A. Raza, S. Nasibi, “An overview of the development of composites containing Mg and Zn for drug delivery”, Journal of Composites and Compounds, vol. 2, pp. 193-204, 2020.