MİNÖR TÜKÜRÜK BEZİ BİYOPSİSİ YAPTIĞIMIZ HASTALARIN ÖZELLİKLERİ: OLGU SERİSİ

Yıl 2016, Cilt: 1 Sayı: 2, 12 - 17, 13.12.2016

Cem Erçalık , Hüseyin Elik Pınar Arda Figen Yılmaz Jülide Öncü , Gülgün Durlanık Beril Doğu , Tülay Erçalık Ahmet Üşen Banu Kuran

Öz

Sjögren Sendromu (SS) ayırıcı tanısında minör tükürük bezi biyopsisi (MTBB) Kulak Burun Boğaz Kliniklerinde
sık yapılan bir işlem olmasına rağmen, Romatoloji Polikliniklerinde de uygulanmaya başlanan
minör invaziv bir yöntemdir. Çalışmamızın amacı MTBB’nin Romatoloji pratiğinde SS tanısındaki
yeri ve gerekliliğinin değerlendirilmesidir. Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi Romatoloji
Polikliniğine ağız ve/veya göz kuruluğu, eklem şikayetleri ile başvuran daha ziyade otoantikor
negatif hastalara yapılan MTBB sonuçlarının değerlendirilmesi sonucunda SS tanısı konuldu. MTBB
invaziv bir girişim olmasına rağmen SS ayırıcı tanısında kullanılan değerli bir tanı aracıdır.

Anahtar Kelimeler

Sjögren sendromu, minör tükürük bezi biyopsisi, artralji

THE CHARACTERISTICS OF PATIENTS WHO UNDERWENT THE MINOR SALIVARY GLAND BIOPSY: CASE SERIES

Öz

Although, minor salivary gland biopsy (MSGB) - a minor invasive method - is a common procedure undertaken
for the definitive diagnosis of Sjörgen’s Syndrome (SS) in the ENT clinics, it is also increasingly
carried out in the outpatient clinics of rheumatology. The objective of our study was to evaluate the place
and the necessity of the MSGB regarding the diagnosis of SS in the rheumatology practice. Patients, who
were rather autoantibody-negative and applied with joint complaints and mouth and/or eye dryness to
the outpatient clinics of rheumatology in Şişli Hamidiye Etfal Training and Research Hospital, were diagnosed
as SS upon evaluation of the results of MSGB. Although, MSGB is an invasive intervention, it is a
valuable diagnostic tool for the definitive diagnosis of SS.

Anahtar Kelimeler

Sjörgen’s syndrome, biopsy of minor salivary gland, arthralgia

Kaynakça

• 1. Colella G, Cannavale R, Vicidomini A, Itro A. Salivary gland biopsy: a comprehensive review of techniques and related complications. Rheumatology (Oxford), 49: 2117-21, 2010.
• 2. Moutsopoulos HM: Sjögren Sendromu. In: Fauci A.S (Ed): Harrison Romatoloji.2th ed. İstanbul, CN: Nobel Tıp Kitapevi, 124-28, 2013.
• 3. Pijpe J, Kalk WW, van der Wal JE, Vissink A, Kluin PM, Roodenburg JL, Bootsma H, Kallenberg CG, Spijkervet FK. Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjögren’s syndrome. Rheumatology, 46(2): 335-41, 2007.
• 4. Santiago ML, Seisdedos MR, Garcia Salinas RN, Catalán Pellet A, Villalón L, Secco A. Usefulness of Antibodies and Minor Salivary Gland Biopsy in the Study of Sicca Syndrome in Daily Clinical Practice. Reumatologia Clinica; 11(3): 156-160, 2015.
• 5. SC Shiboski, CH Shiboski, LA Criswell, AN Baer, S Challacombe, H Lanfranchi et al. AmericanCollege of Rheumatology Classification Criteria for Sjogren’sSyndrome: A Data-Driven, Expert Consensus Approach in theSjogren’s International Collaborative Clinical Alliance Cohort. Arthritis Care & Research, 64(4): 475-87, 2012.
• 6. Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM et al. Preliminary criteria for the classification of Sjögren’s syndrome: results of a prospective concerted action supported by the European Community. Arthritis Rheum, 36(3): 340-7, 1993.
• 7. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE et al. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by th eAmerican-European ConsensusGroup. Ann Rheum Dis, 61(6): 554-8, 2002.
• 8. Vitali C, Bombardieri S, Moutsopoulos HM, Coll J, Gerli R, Hatron PY et al. Assessment of the European classification criteria for Sjögren’s syndrome in a series of clinically defined cases: results of a prospective multicentre study. The European Study Group on Diagnostic Criteria for Sjögren’s Syndrome, Ann Rheum Dis, 55(2): 116-21, 1996.