Investigation on Photon Interaction Properties of Some Polymers Used in Production of Hydrogels

Abstract

Due to their excellent features and applications, hydrogels become so popular and are used for fabricating contact lenses, cancer treatment, hygiene products, tissue engineering, drug and delivery systems. Simultaneously use of hydrogels with radiotherapy is known to be effective in protecting the healthy cells from high radiation. From this point on, it is necessary to know radiation attenuation properties of compounds used in production of hydrogel. In the present study, half value layer (HVL), effective atomic number (Zeff), effective electron density (Nel) and energy absorption and exposure buildup factors (EABF and EBF) of eight hydrogel samples (hyaluronic acid, chitosan, fibrin, dextran sulfate, pectin, alginic acid, chondroitin sulfate and carrageenan) have been investigated. From the obtained results, it might be concluded that these parameters depend on the elemental composition of the samples. It is seen that dextran sulfate has most superior radiation absorption capacity while fibrin has the lowest when compared to other samples.

Keywords

• Hydrogel,Radiation,HVL,Effective atomic number,Buildup factor

Hidrojel Üretiminde Kullanılan Bazı Polimerlerin Foton Etkileşim Özelliklerinin İncelenmesi

Abstract

Mükemmel özellikleri ve uygulamaları nedeniyle, hidrojeller son derece popülerdir ve kontakt lenslerin üretimi, kanser tedavisi, hijyen ürünleri, doku mühendisliği ve ilaç verme sistemleri için kullanılır. Hidrojellerin radyoterapi ile eş zamanlı kullanımının, sağlıklı hücrelerin yüksek radyasyondan korunmasında etkili olduğu bilinmektedir. Bu noktadan hareketle, hidrojel üretiminde kullanılan bileşikerin radyasyon azaltma özelliklerini bilmek gereklidir. Bu çalışmada, sekiz hidrojel örneğinin (aljinik asit, hiyalüronik asit, kitosan, fibrin, carrageenan, pektin, kondroitin sülfat ve dekstran sülfat ) yarı değer kalınlığı (HVL), etkin atom numarası (Zeff), etkin elektron yoğunluğu (Nel) ve enerji absorpsiyon ve maruz kalma kuvvetlendirme faktörleri (EABF ve EBF) incelendi. Elde edilen sonuçlara göre, bu parametreler, numunelerin elementel kompozisyonuna bağlı olup, diğer örnekler ile kıyaslandığında dekstran sülfatın daha üstün radyasyon soğurma kapasitesine sahipken fibrinin en az olduğu görülebilir. 

Keywords

• HVL,Hidrojel,Radyasyon,Etkin atom numarası,Kuvvetlendirme faktörü

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