Eş Zamanlı İnsülin ve Glukagon Konsantrasyon Artışının Karaciğer Glikoz Üretimine Etkisinin Matematik Model Kullanarak Analizi

Yıl 2024, Cilt: 28 Sayı: 2, 268 - 280, 23.08.2024

Perihan Hatice Aydın , Fatih Karaaslan

https://doi.org/10.19113/sdufenbed.1316013

Öz

Sağlıklı kişilerde, kan glikoz değeri dar bir aralıkta sabit olarak tutulur. İnsülin hormonu, kan glikoz konsantrasyonu artışında salgılanır ve dokularda glikoz kullanımını artırarak ve karaciğerde glikoz üretimini azaltarak, glikoz konsantrasyonun normal değerine inmesine yardımcı olur. Glukagon ise, glikoz konsantrasyonu azaldığında salgılanır ve karaciğerden glikoz salınımını artırarak, glikoz konsantrasyonunun artmasına etki eder. İnsülin ve glukagon hormonlarının, karaciğerde glikoz üretimi üzerine olan bu zıt etkileri bilinmesine rağmen, eş zamanlı insülin ve glukagon artışının karaciğerde glikoz üretimine etkisi hakkında yapılmış az sayıda in vivo çalışma vardır. İnsülin ve glukagonun, eş zamanlı artışında, karaciğerden glikoz çıkışını test etmek için bir matematik model geliştirilmiştir. Glikoz, insülin ve glukagon dinamiklerini içeren bu model, öncelikle, sağlıklı insanlar üzerinde yapılmış çeşitli çalışma sonuçları ile test edilmiştir. Modelin, glikoz tolerans testi, insülin infüzyonu, insülin ve glikoz infüzyonu, glukagon infüzyonu çalışmalarına benzer sonuçlar verdiği gözlenmiştir. Daha sonra, modelde, eş zamanlı olarak, insülin ve glukagon infüzyonu ile, kan insülin ve glukagon konsantrasyonları yaklaşık 4 katına çıkarıldığında, karaciğerden glikoz çıkışının azaldığı gözlenmiştir. Bu sonuç, insülin hormonunun karaciğer glikoz üretimini inhibe edici özelliğinin, glukagonun glikoz üretimini uyarıcı etkisinden daha güçlü olduğu hipotezini desteklemektedir.

Anahtar Kelimeler

Glikoz, İnsülin, Glukagon, Matematik Model

Kaynakça

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