Fibromyalji'li hastalarda serum 25-hidroksi D vitamini ve parathormon düzeyleri

Year 2006, Volume: 13 Issue: 2, 26 - 30, 21.04.2009

Mahmut Yener Selami Akkuş

Abstract

SüleymanDemirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2006 Haziran; 13(2)


Araştırma Makalelesi


Fibromyalji'li hastalarda serum 25-hidroksi D vitamini ve parathormon düzeyleri

Mahmut Yener, Selami Akkuş



Özet


Son zamanlarda yapılan çalışmalar düşük D vitamini düzeyleri ile nonspesifik kas iskelet sistemi semptomları arasında ilişki olduğunu bildirmektedir. Bu çalışmanın amacı fibromyaljili hastalarda D vitamini ve parathormon düzeylerini araştırmak ve bu değerlerin yaş, ırk, deri rengi, iklim, enlem özellikleri açısından aynı olan kontrol grubu değerleri ile karşılaştırmaktır. Çalışmaya 34 fibromiyaljili premenopozal kadın ve 34 sağlıklı premenopozal kadın alındı. Serum parathormon düzeyleri fibromiyaljili hastalarda kontrol grubuna göre anlamlı şekilde yüksek bulundu. D vitamini düzeyleri fibromiyaljili grupta düşük bulunmakla birlikte, bu fark istatistiksel olarak anlamlı değildi. Fibromiyaljili hastalarda yüksek parathormon düzeylerini izah edemiyoruz. Bu nedenle fibromiyaljide parathormonun rolünü araştıran daha ileri çalışmalara ihtiyaç vardır.


Anahtar kelımeler: Fibromyalji, D vitamini, Parathormon


Abstract


Serum 25-hydroxy vitamin D and parathormon levels in patients with fibromyalgia



Recent studies reported that low vitamin D levels are related to nonspesific musculoskeletal symptoms. The aim of this study was to investigate the vitamin D and parathormon levels in premenopousal women with fibromyalgia and to compare with control group who are similar according to age, race, skin color, climate and latitute with the study group. The study group consists of 34 premenopausal women with fibromyalgia and the control group consists of 34 healty premenopausal women. Serum parathormon levels were found significantly higher in fibromyalgia group than the control group. Despite vitamin D levels were lower in fibromyalgia group this difference was not found statistically significant. We could not explain high level of parathormon in patients with fibromyalgia, so further studies are needed to investigate the role of parathormon in fibromyalgia.


Key words: Fibromyalgia, Vitamin D, Parathormon

Keywords

Fibromyalji, D vitamini, Parathormon

References

• Holick MF. Too little vitamin D in premenopausal women: why should we care?. Am J Clin Nutr 2002;76:3–4
• Reginato AJ, Falasca GF, Pappu R, McKnight B, Agha A. Musculoskeletal manifestation of osteomalacia: report of 26 cases and literature review. Semin Artritis Rheum 1999;28:287-304
• Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ. Prevalence of Vitamin D Insufficiency in an Adult Normal Population. Osteoporos Int 1997;7:439–43
• Mishal AA. Effects of different dress styles on vitamin D levels in healthy young Jordanian women. Osteoporos Int 2001;12:931–5
• Scharla SH. Prevalence of subclinical vitamin D deficiency in different European countries. Osteoporos Int 1998;8:7-12
• Carnevale V, Modoni S, Pileri M, Di Giorgio A, Chiodini I, Minisola S, Vieth R, Scillitani A. Longitudinal evaluation of vitamin D status in healthy subjects from southern Italy: Seasonal and gender differences. Osteoporos Int 2001;12:1026–30
• Holick MF. Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes 2002;9:87–98.
• Zanello SB, Collins ED, Marinissen MJ, Norman AW, Boland RL. Vitamin D receptor expression in chicken muscle tissue and cultured myoblast. Horm Metab Res. 1997 May;29(5):231-6
• Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78:1463–70.
• Mascarenhas R, Mobarhan S. Hypovitaminosis D- induced Pain. Nutrition Reviews, 2004;62:354-9
• Al-Allaf AW, Mole PA, Paterson CR, Pullar T. Bone health in patients with fibromyalgia. Rheumatology 2003;42:1202-6
• Huisman A.M, Whýte K.P, Algra A, Harth M, Výeth R, Jacobs J.W.J, Býjlsma, and Bell A.D. Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia. J Rheumatol 2001;28:2535-9
• Thomas MK, Demay MB Vitamin D deficiency and disorders of vitamin D metabolism. J Endocrinol Metab Clin North Am 2000;29:611-27
• Gannage –Yared MH, Chemali R, Yaaccoub N, Halaby G Hypovitaminosis D in a sunny country: relation to lifestily and bone markers. J Bone Miner Res 2000;15:1856-62
• Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, Charles P, Eriksen EF, Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med 2000;247:260-8
• Wolfe F. Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American Collage of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33(2):160- 72.
• Hollick MF. Vitamin D: a millenium perspective. J
• Cell Biochem.2003;88:296-307.
• Akkuþ S, Tamer M.N, Yorgancigil H. A case of osteomalacia mimicking ankylosing spondylitis Rheumatol Int 2001;20:239-42
• Akkuþ S, Okudan B, Yener M, Cindaþ A, Savaþ S, Yýldýz M. Bone mineral density and biochemical markers of bone turnover in patients with fibromyalgia. Osteoporosis Int 2005;16:S78-9 (abstract).
• Chou FF, Lee CH, Chen JB, Hrang SC, Lee CT. Sleep disturbances before and after parathyroidectomy for secondary hyperparathyroidism. Surgery 2005; 137(4): 426-30.
• Korszun A. Melatonin levels in women with FMS and CFS. J Rheumatol 1999; 2 6(12): 2675-80
• Gannage –Yared MH, Chemali R, Yaacoob N, Halaby G. Hypovitaminosis D in a sunny country: relation to lifestyle and bone markers. J Bone Miner Res 2000 Sep; 15(9): 1856-62
• Raphael KG, Marbach JJ Comorbid fibromyalgia accounts for reduced fecundity in women with myofascial face pain. Clin J Pain 2000;16: 29-36.
• Schoctat T, Beckmann Sociodemographic characteristics, risk factors and reproductive history in subjects with fibromyalgia-results of a population- based case-control study. Z Rheumatol 2003;62: 46- 59.
• Gür A, Cevik R, Nas K, Colpan L, Sarac S. Cortisol and hypothalamic-pituitary-gonadal axis hormones in follicular-phase women with fibromyalgia and chronic fatigue syndrome and effect of depressive symptoms on these hormones. Arthritis Research Therapy 2004;6: 232-8.
• Korszun A, Young AE, Engleberg NC. Follicular phase hypothalamic-pituitary-gonadal axis function in women with fibromyalgia and chronic fatigue syndrome. J Rheumatol 2000;27: 1526-30.
• Macfarlane TV, Blinkhorn A, Worthington HV, Davies RM, Macfarlane GJ. Sex hormonal factors and chronic widespread pain: a population study among women. Rheumatology 2002;41: 454-7.