Derleme
BibTex RIS Kaynak Göster

Kanserde MikroRNA’lar ve İlaç Yanıtı

Yıl 2018, Cilt: 25 Sayı: 4, 498 - 507, 01.12.2018
https://doi.org/10.17343/sdutfd.345988

Öz

MikroRNA’lar
(miRNA), hedef gen ekspresyonunu post-transkripsiyonel olarak kontrol eden
küçük kodlanmayan RNA molekülleridir. miRNA’ların hedef genleri baskılayarak
büyüme, gelişme, farklılaşma ve hücre ölümü süreçlerinin düzenlenmesinde önemli
rol oynadığına dair çok sayıda çalışma mevcuttur. MiRNA’ların düzenlenmesindeki
bozuklukların kanser ile bağlantılı olması bu bağlamda şaşırtıcı değildir. Buna
ek olarak, m
iRNA
ifadelerinin ilaçlar tarafından değiştirilebildiği ve miRNA'ların kanser
tedavisinde ilaç metabolizmasının düzenlenmesini ve toksisiteyi etkilediği
bildirilmiştir.
İlaç yanıtı, hem
genetik hem de çevresel faktörler tarafından düzenlenen karmaşık bir süreçtir.
Bugüne kadar farklı miRNA'ların birçok antikanser terapiye karşı duyarlılığı
öngördüğü veya etkilediği bulunmuştur. Bu
derleme de, miRNA biyojenezini takiben,
miRNA'ların kanser, ilaç yanıtı ve antikanser tedavileri üzerindeki potansiyel
rolünü ortaya koyan mevcut çalışmaların tartışılması  amaçlanmıştır. 

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Toplam 73 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derlemeler
Yazarlar

Çiğdem Aydın Acar

Şükriye Yeşilot

Yayımlanma Tarihi 1 Aralık 2018
Gönderilme Tarihi 23 Ekim 2017
Kabul Tarihi 22 Ocak 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 25 Sayı: 4

Kaynak Göster

Vancouver Aydın Acar Ç, Yeşilot Ş. Kanserde MikroRNA’lar ve İlaç Yanıtı. Med J SDU. 2018;25(4):498-507.