Yıl 2020, Cilt 27 , Sayı 1, Sayfalar 145 - 153 2020-03-01

ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ

Sibel AKAR [1] , Emel Öykü ÇETİN UYANIKGİL [2]


Günümüzde yara iyileşmesi üzerine yapılan bir çok çalışma bulunmaktadır. Yara iyileşmesinde etkili olduğu kanıtlanan birçok etkin madde ve farmasötik dozaj şekli tanımlanmıştır. Antimikrobiyal peptitler (AMP) insanların, hayvanların ve bitkilerin bir çok doku ve organları tarafından üretilen peptitlerdir ve doğal immün sistemin yadsınamaz savaşçılarıdır. AMP’ler; antibakteriyel, antiviral, antifungal, antiparazitik, insektisidal, kemotaktik, yara iyileşmesi ve büyüme uyarıcı olarak pek çok etkiye sahip olabilmektedirler. AMP’lerin, proinflamatuar yanıttaki potansiyelleri üzerine yapılan pek çok çalışma bulunmaktadır. AMP’ler yara iyileşmesinde rol almalarının yanı sıra bir çok insan dermal hastalığında da önemli bir potansiyel taşımaktadırlar. Bu yazıda proinflamatuar yanıtın bir parçası olan yara iyileşme sürecinde gerçekleşen birbiri ile bağlantılı basamaklar açıklanmış ve bu basamaklarda AMP‘lerin aldıkları roller ve önemlerinden bahsedilmiştir; ayrıca insan dermal hastalıklarındaki potansiyellerinin araştırıldığı çalışmalara da değinilmiştir.

antimikrobiyal peptit, yara, proinflamatuar, LL-37, hBD-3
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Birincil Dil tr
Konular Eczacılık
Bölüm Derlemeler
Yazarlar

Yazar: Sibel AKAR
Kurum: Ege Üniversitesi Fen Bilimleri Enstitüsü Biyoteknoloji ABD
Ülke: Turkey


Orcid: 0000-0001-8822-9130
Yazar: Emel Öykü ÇETİN UYANIKGİL (Sorumlu Yazar)
Kurum: Ege Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji ABD Biyofarmasötik ve Farmakokinetik BD
Ülke: Turkey


Tarihler

Başvuru Tarihi : 31 Ekim 2019
Kabul Tarihi : 20 Aralık 2019
Yayımlanma Tarihi : 1 Mart 2020

Bibtex @derleme { sdutfd641016, journal = {SDÜ Tıp Fakültesi Dergisi}, issn = {1300-7416}, eissn = {2602-2109}, address = {}, publisher = {Süleyman Demirel Üniversitesi}, year = {2020}, volume = {27}, pages = {145 - 153}, doi = {10.17343/sdutfd.641016}, title = {ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ}, key = {cite}, author = {AKAR, Sibel and ÇETİN UYANIKGİL, Emel Öykü} }
APA AKAR, S , ÇETİN UYANIKGİL, E . (2020). ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. SDÜ Tıp Fakültesi Dergisi , 27 (1) , 145-153 . DOI: 10.17343/sdutfd.641016
MLA AKAR, S , ÇETİN UYANIKGİL, E . "ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ". SDÜ Tıp Fakültesi Dergisi 27 (2020 ): 145-153 <https://dergipark.org.tr/tr/pub/sdutfd/issue/52788/641016>
Chicago AKAR, S , ÇETİN UYANIKGİL, E . "ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ". SDÜ Tıp Fakültesi Dergisi 27 (2020 ): 145-153
RIS TY - JOUR T1 - ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ AU - Sibel AKAR , Emel Öykü ÇETİN UYANIKGİL Y1 - 2020 PY - 2020 N1 - doi: 10.17343/sdutfd.641016 DO - 10.17343/sdutfd.641016 T2 - SDÜ Tıp Fakültesi Dergisi JF - Journal JO - JOR SP - 145 EP - 153 VL - 27 IS - 1 SN - 1300-7416-2602-2109 M3 - doi: 10.17343/sdutfd.641016 UR - https://doi.org/10.17343/sdutfd.641016 Y2 - 2019 ER -
EndNote %0 SDÜ Tıp Fakültesi Dergisi ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ %A Sibel AKAR , Emel Öykü ÇETİN UYANIKGİL %T ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ %D 2020 %J SDÜ Tıp Fakültesi Dergisi %P 1300-7416-2602-2109 %V 27 %N 1 %R doi: 10.17343/sdutfd.641016 %U 10.17343/sdutfd.641016
ISNAD AKAR, Sibel , ÇETİN UYANIKGİL, Emel Öykü . "ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ". SDÜ Tıp Fakültesi Dergisi 27 / 1 (Mart 2020): 145-153 . https://doi.org/10.17343/sdutfd.641016
AMA AKAR S , ÇETİN UYANIKGİL E . ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. SDÜ Tıp Fakültesi Dergisi. 2020; 27(1): 145-153.
Vancouver AKAR S , ÇETİN UYANIKGİL E . ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. SDÜ Tıp Fakültesi Dergisi. 2020; 27(1): 153-145.