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ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ

Yıl 2020, Cilt: 27 Sayı: 1, 145 - 153, 01.03.2020
https://doi.org/10.17343/sdutfd.641016

Öz

Günümüzde yara iyileşmesi üzerine yapılan bir çok çalışma
bulunmaktadır. Yara iyileşmesinde etkili olduğu kanıtlanan birçok etkin madde
ve farmasötik dozaj şekli tanımlanmıştır. Antimikrobiyal peptitler (AMP)
insanların, hayvanların ve bitkilerin bir çok doku ve organları tarafından
üretilen peptitlerdir ve doğal immün sistemin yadsınamaz savaşçılarıdır. AMP’ler;
antibakteriyel, antiviral, antifungal, antiparazitik, insektisidal, kemotaktik,
yara iyileşmesi ve büyüme uyarıcı olarak pek çok etkiye sahip
olabilmektedirler. AMP’lerin, proinflamatuar yanıttaki potansiyelleri üzerine
yapılan pek çok çalışma bulunmaktadır. AMP’ler yara iyileşmesinde rol
almalarının yanı sıra bir çok insan dermal hastalığında da önemli bir
potansiyel taşımaktadırlar. Bu yazıda proinflamatuar yanıtın bir parçası olan yara
iyileşme sürecinde gerçekleşen birbiri ile bağlantılı basamaklar açıklanmış ve
bu basamaklarda AMP‘lerin aldıkları roller ve önemlerinden bahsedilmiştir;
ayrıca insan dermal hastalıklarındaki potansiyellerinin araştırıldığı
çalışmalara da değinilmiştir.

Kaynakça

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Toplam 68 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Eczacılık ve İlaç Bilimleri
Bölüm Derlemeler
Yazarlar

Sibel Akar Bu kişi benim

Emel Öykü Çetin Uyanıkgil 0000-0001-8822-9130

Yayımlanma Tarihi 1 Mart 2020
Gönderilme Tarihi 31 Ekim 2019
Kabul Tarihi 20 Aralık 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 27 Sayı: 1

Kaynak Göster

Vancouver Akar S, Çetin Uyanıkgil EÖ. ANTİMİKROBİYAL PEPTİTLERİN PROİNFLAMATUAR YANITTAKİ POTANSİYELLERİ. SDÜ Tıp Fak Derg. 2020;27(1):145-53.

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Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.